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Post Info TOPIC: Gene Therapy Primary Research

Phase Two

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Date: Mon Jan 15 9:09 PM, 2007
Gene Therapy Primary Research

Efficient Non-Viral Ocular Gene Transfer with Compacted DNA Nanoparticles
(Published: December 20, 2006)

Copyright: 2006 Farjo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

"The eye is an excellent candidate for gene therapy as it is immune privileged and much of the disease-causing genetics are well understood. Towards this goal, we evaluated the efficiency of compacted DNA nanoparticles as a system for non-viral gene transfer to ocular tissues. ..."

"Taken together, our data suggest that this mode of gene therapy is applicable for multiple forms of ocular diseases. As intravitreal injection targets the tissues in the front of the eye, this mode of therapy could be widely applicable for corneal diseases such as cataracts and keratoconus...."

"This nanoparticle system shows tremendous promise as the basis for developing strategies to treat various diseases of the eye. ..."

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PLoS ONE (eISSN-1932-6203) is an international, peer-reviewed, open-access, online publication from the Public Library of Science (PLoS). PLoS ONE welcomes reports on primary research from any scientific discipline.

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