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Post Info TOPIC: conference in France...news on genetic link & news on intacs


Veteran Member

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Posts: 25
Date: Thu Aug 25 11:46 PM, 2005
RE: conference in France...news on genetic link & news on intacs
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Hi


Forget the last link....might not be able to access it...


try this version...


www.ophsource.org/search/quick


type keratoconus in the box and you'll see hundreds of articles


the one I was looking at was no.10


"inflammatory molecules in the tears of patients with kertoconus"


Hope this link works


Sandi



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sandi


Veteran Member

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Posts: 25
Date: Fri Aug 26 12:01 AM, 2005
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Hi


Could someone tell me how I send a personal message please?


Need to ask about a different way of sending some links that I have.


Thank you


Sandi



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sandi
Anonymous

Date: Fri Aug 26 12:39 AM, 2005
RE: conference in France...news on genetic link & news on intacs
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I'll send you a PM, and when you get it a message will come up near the log in area the (next time you log in), saying that you have a messge... click on it go through to read your message and then you will have a better idea of how it works. To send find the users name on the forum and click on it and a drop down menu will have a button to press to write and then after that you can send the messge. Reply to the messge i have sent you and then you will know how to send.

BTW your a great team player!!

I wanted to go through that link you posted Sandi to see if we can connect a few things together hopfully with my friend and genius Yarsky with the scientific background that he has and also very exceptional brain

Ciao for now

-- Edited by QuintriX at 05:42, 2005-08-26

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Executive

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Posts: 437
Date: Fri Aug 26 11:05 AM, 2005
RE: conference in France...news on genetic link & news on intacs
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Hi Sandi thanks for posts!


Quintrix, logic is as follows, but it's just my speculation:


1. Aquaporines are missing because of the genetics


2. The lack of acuaporines results in free passage of positive ions in zones where they should not go.


3. When their concentration in the cornea (do not now exactely where, they could be very inhomogeniously distributed) is high enough (trigger concentration) the slippage, drift etc. of collagen fibers begins.


4. So i think, if aquaporines hypothesis is valid, the trigger is the level of concentration of positive ions in the cornea.


5. Positive ions excess mean that the media is acid, lack of positive ions - media is basic, equal quantities - neutral.


6. Ioniser of air....am not sure but may be


7. So the question is why the concnetration of + ions reaches it's trigger level...do not know...there are positive ions all the time in our bodys...but what is interesting is to try to explain what Meek et al observed (remeber the article abour x_ray difraction on KC and normal corneas) from the point of view of ionic disbalance...


A lot of resaerch. I'm sure in months to come, probably next year, something should appear in this respect in the literature...


But along with the reason for KC we need a cure...



-- Edited by Yarsky at 11:07, 2005-08-26

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yarsky
Anonymous

Date: Fri Aug 26 4:34 PM, 2005
RE: conference in France...news on genetic link & news on intacs
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A must read article...

The title of the link below is called..

Report of the Corneal Diseases Panel

Program Overview and Goals

Strategic Plans from the National Eye Institute

Have a great weekend everyone


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Anonymous

Date: Fri Aug 26 9:00 PM, 2005
RE: conference in France...news on genetic link & news on intacs
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Read the title guys of this link... am i seeing things

Please Click Here

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Anonymous

Date: Mon Aug 29 1:56 AM, 2005
RE: conference in France...news on genetic link & news on intacs
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Well Guys... i am speechless again as i don't know what to say about this link... so help!!!

ok i'll say it anyway...

"Aquaporins as potential drug targets" says this next link.

It looks like cracking this code would help many disoders and so there is much interest to accomplish this. Where that could lead to, who knows? but its all for the good i think...


Caio for now

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Executive

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Posts: 437
Date: Mon Aug 29 3:14 PM, 2005
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As far as I know, ionic and water transport in living bodies are extremely important. We see the AQPs play an important role in this. Their luck may be crucial. Where do they come from? Who makes thier supply? How to build drugs to cure their lack? Still not very clear... I am just a patient with KC and some natural science background, i can just speculate: it's like to shot being blind.  As for KC, it's AQP 5 that lacks in KC epithelium. It was shown that normal lacrimal glands produce this AQP5 and supply it to epithelial cells, and probably the whole cornea. As far as I can imagine, AQPs tend to build themselvs in membranes, to modulate the transport of water and ions. If their lack is expressed in keratocyte membranes, well, then...You see, keratocytes are living things. They produce (synthesise) collagens for many reasons. Now, imagine you have just collagen fibers with nothing amogst them. Naturally this system will collapse or coagulate for there are attraction forces between the fibers and fibers' parts. Keratocytes, I believe, play a stabilisator's role in this system. Probably, normally they are polarised (interior basic or neutral (I do not know, to my shame)), exterior a bit acid for + ions do not go inside, so they stay outside. If the transport of positive ions is purturbed, the polarisation of keratocytes may go away. Thus the stabilisator property of the keratocytes network may go away. Attraction between collagen fibres grows relatively stronger than ammortisation supplied by keratocytes. Collagens start to move toward each other, probably smashing keratocytes, forming what may ressemble a "ball of snakes". This may explain why collagen go lose from their anchors in limbus: the same reason: attraction between collagens' parts is bigger than any other interaction. Well, this is just speculation...


 


 



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yarsky
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