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Post Info TOPIC: conference in France...news on genetic link & news on intacs


Veteran Member

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Posts: 25
Date: Mon Aug 22 10:34 PM, 2005
conference in France...news on genetic link & news on intacs
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Hi


might be of interest?


http://www.laser-prk.com/pressrelease.htm


at bottom of screen click links to view pdf....


part1 is quite technical(and some in french!)


part 2  easier (for me)to understand...causes+1..genetics..intacs


Take Care


Sandi



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sandi


Executive

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Date: Tue Aug 23 9:49 AM, 2005
RE: conference in France...news on genetic link & news on intacs
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Hi Sandi!


Very interesting link!


In particular, it is devoted to the SFO invited guest, a US researcher Dr. Rabinowitz, who was a part of recent corneal genome research and who made some evolution in Intacts. Extremly inetersting is the following conclusion from the genome study:"...As part of the study, the researchers were the first ever to describe a molecular defect in keratoconus, an absence of transcripts for the water channel protein Aquaporin 5 (AQP5). The description has the potential to be developed into a molecular genetic test to detect keratoconus in its early stages..."


What does it mean "...an absence of transcripts for the water channel protein Aquaporin 5 (AQP5)... "?



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yarsky
Anonymous

Date: Tue Aug 23 12:54 PM, 2005
RE: conference in France...news on genetic link & news on intacs
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Hello there,


...it's me the forum chatting to you... I have not had the time to even scan through much lately in detail, been looking in to some other things as some of the veteran members know.


Anyway thanks again Sandi (soon to be Veteran member ) you are a very valued member of our team, your finger tip precision is excellent work with the posts that you have posted!!


Anyway take care and please post again soon!



-- Edited by QuintriX at 12:55, 2005-08-23

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Date: Tue Aug 23 2:22 PM, 2005
RE: conference in France...news on genetic link & news on intacs
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Sandi, your post is excelent.


Look what I found.


The abscence of acuaporines in KC corneas...What may it mean?


First. What are acuaporines? Acuaporines are special proteins that are additional water chanenls that at the same time bloc positive ions. In 2003 Peter Agre from John Hopkins Uni recieved Nobel Price in Chemistry for the discovery of acuaporines. Here is his Nobel (and very interesting) lecture


http://www.science.fau.edu/chemistry/Mari/advbiochem/Agre.pdf


Second, Mr. Rabinowits et al made a list off all proteins in cornea. In normal corneas there are acuaporines. In KC - no. Which (the abscence of aquaporines in KC membranes) may mean (my guess) that in our KC corneas there are a) not enough water b) a huge exess of positive ions. This exess may create pure electostatic effects that may be responsible for collagen drift that results in corneal shape change...Please comment...All this is just my guess... 



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yarsky


Executive

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Date: Tue Aug 23 4:48 PM, 2005
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Here it is, the abstract that speaks about this study.


http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15790884&dopt=Citation


It was clearly a genetic study where as material people used KC corneas taken away during grafts. They found some new genes but acuaporines was the top discovery.


What is uncertain:


- where are these aquaporines normally located in the cornea: epithelium? endothelium? keratocytes?


- in the lecture of Agre hereabove, I read that aquaporine 5 is secreted by lacrimal glande and in principally can be found in epitheilal cells...


-if KC tears lack this acuaporine and if KC epithelium lack it than, in part, positive ions come inside with tears.


- what is the pH of normal tears and what is the pH of KC tears? Who knows? It may be very important...


Please comment.


 



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yarsky
Anonymous

Date: Wed Aug 24 12:39 PM, 2005
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Hi Yarsky, I am going to go through the links you posted in the evening today... as i want to give this some time... I do see what you and Sandi have posted has created something major...

All the Best

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Anonymous

Date: Wed Aug 24 11:17 PM, 2005
RE: conference in France...news on genetic link & news on intacs
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Hi Yarsky, I think what you say is all good stuff...I have heard of one brother who has mild kc and has an ionisor in his office and his brother who was diagnosed quite recently had advanced kc...and he never had an ionisor... i know its only one story but it ties in to what you say (also the bioeletronic treatment the lombardi clinic does covers a few things got to do with +/- ions and such things like static...not sure if there is any relavance but i thought i would just let you know about this)

Also about the water...thats interesting as well...as someone posted once that they started drinking a lot of water and there kc seemed to deminish... so i think there could be something there.

I think the genetic thing we can not change... but the trigger can be controled or eliminated.

Yarsky what couses the acuaporines to be missing?...do you think its due to gentics or something else...and tell me what in your honest opinion is the trigger?

And about the ph of tears that is a very good question... i think tears may be a big suspect....which has not been questioned yet...

Great stuff yarsky and well done...I think at this rate you will crack the code that kc has held as a secret for so long...too long

I would like to very much bomb the base....I hear on Ebay you can get "mustard gas" lolol...i'm with you on this cursade buddy

-- Edited by QuintriX at 23:23, 2005-08-24

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Veteran Member

Status: Offline
Posts: 25
Date: Thu Aug 25 11:26 PM, 2005
RE: conference in France...news on genetic link & news on intacs
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Hi again


don't know if this might fit in.....


"inflammatory molecules in the tears of patients with KC"


http://www.ophsource.org/periodicals/ophtha/article/PIIS0161642004019189/abstract


Take care


Sandi



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sandi
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