All of us Vs Keratoconus

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Post Info TOPIC: RGP Research Findings


Status: Offline
Posts: 13
Date: Wed Aug 20 2:10 PM, 2008
RGP Research Findings

Just found this in a google alert, on OSN. Can anyone help decipher what this may mean in terms of the advisability of wearing RGPs if you have severe KC?

OSN SuperSite Breaking News 8/18/2008

RGP contact lenses may increase levels of inflammatory molecules in keratoconus patients

Wearing rigid gas permeable contact lenses appears to stimulate overexpression of interleukin-6, tumor necrosis factor, intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 in the tears of keratoconus patients, a prospective study found. In addition, these increased levels of inflammatory molecules are higher in patients with severe keratoconus.

To determine the levels of inflammatory molecules in the tears of RGP contact lens patients, Isabel Lema, MD, PhD, and colleagues collected 15 µL of tears from 48 eyes of 48 patients with keratoconus and 40 eyes of 40 patients with myopia. Specifically, 20 keratoconus patients wore RGP contact lenses and 28 keratoconus patients were not lens wearers; 20 myopic patients were lens wearers and 20 myopic patients were not lens wearers.

The investigators used enzyme-linked immunosorbent assay to measure the concentration of inflammatory molecules, including interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor (TNFa), intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1) and matrix metalloproteinase (MMP-9).

Among keratoconus patients, the most significant differences associated with RGP contact lens wear were increased levels of IL-6 (P = .001), TNFa (P = .028) ICAM-1 (P


"I was looking for an answer. It's the question that drives us, Neo. It's the question that brought you here."

Senior Member

Status: Offline
Posts: 103
Date: Thu Aug 21 12:23 PM, 2008

Its amazing how they never talk about the negative effects of RGPs or allow people to, but blame it on the KC like if it is a case "spontaneous combustion"

Thank you for posting this.

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