All of us Vs Keratoconus

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Post Info TOPIC: Stem Cells for Cornea

Date: Tue Oct 18 1:11 AM, 2005
RE: Stem Cells for Cornea

Here is a fact sheet you can download about stem cell transplants (it's not good news as it says that stem cell transplants can not be used for kc patients)



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Posts: 437
Date: Tue Oct 18 7:56 PM, 2005

Yea, interesting. Interesting to know why it is not good for KC.
They say: "only eye surface". Meaning epithelium, yes?
Which means that KC is not an epithelum thing. Well, not only epithelium.
Inside, as cells, we have: keratocytes and endothelium.
As we know endothelium cells are damaged. Keratocytes also. Keratocytes seem to be squeezed by collagens. Still not clear is KC a cell thing at all or how the cells are involved....


Date: Tue Oct 18 8:27 PM, 2005

I think your right yarsky...

Check this link out, a member sent it in to me..

Please Click here

This is an excerpt from the link:

"There are two major approaches to regenerative medicine. One way is to cause stem or progenitor cells within the patient to expand and differentiate to the cell or tissue type of interest by the use of specific protein cytokines or growth factors. The other method is to isolate cells from a donor and then inject or transplant them to a patient. Alternatively, stem cells can be isolated from the patient, manipulated in vitro and then re-introduced to the patient."

So one "approach" has been crossed of the list of possible treatments for us, the other "approach" may still work for us!

All the best


Phase Two

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Posts: 484
Date: Sun May 13 9:48 AM, 2007

In search of the holy grail, I hope they find it one day. BTW I don't know if you guys heard of "dolly the sheep" and what happened to her (premature aging) when it came to cloning (the first mammal to be) which is one end of the genetic engineering field they have not come to terms with.

"Bone marrow stem cells may cure abnormal corneal cell growth

11 May 2007

A new study has found that bone marrow stem cells can switch roles and produce keratocan, a natural protein involved in the growth of the cornea, the transparent, outer layer of the eyeball.

Washington, May 11 (ANI): A new study has found that bone marrow stem cells can switch roles and produce keratocan, a natural protein involved in the growth of the cornea, the transparent, outer layer of the eyeball.

This study, which has found the ability of marrow cells to 'differentiate' into keratocan-producing cells, might provide a means for treating abnormal corneal cell growth in people, which is a genetic disease.

The study was conducted by a team of researchers led by Winston Whei-Yang Kao and Hongshan Liu at University of Cincinnati.

As part of the study, researchers induced corneal abnormalities that mimicked genetic eye mutations, in mice and then injected bone marrow stem cells into the corneas to see if they altered the mutations.

Researchers found that after only one week, the abnormal corneas of animal models injected with bone marrow stem cells began to change shape and heal.

"We found that bone marrow stem cells can contribute to the formation of connective tissues. If we can change the function of non-corneal bone marrow stem cells by introducing them into human corneas, we can possibly repair the loss of visual sharpness caused by mutations," Kao said.

Researchers are now planning a clinical trial. If the trial succeeds the procedure could help prevent blindness in future generations who suffer from genetic corneal diseases.

"When the donor cells disappear after a few years, the corneal disease often reoccurs. However, if we can place the stem cells inside the cornea, they will repair the lost function of the mutated gene, and stem cells can presumably renew themselves and maintain effective treatment longer, if not forever," Kao said.

The findings of the research were presented at the annual meeting of the Association for Research in Vision and Ophthalmology."

-- Edited by QuintriX at 09:51, 2007-05-13


Senior Member

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Posts: 122
Date: Sun Oct 7 9:52 AM, 2007

Corneal tissue created from stem cells (2nd link down)

a news item about it

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