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A courtesy distribution service and an open-access archive for nearly 2.4 million scholarly articles in the relevant fields and adjacent fields of physics, mathematics, computer science, quantitative biology, quantitative finance, statistics, electrical engineering and systems science, and economics.
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KCFreedom
A discrete-to-continuum model for the human cornea with application to keratoconus
Abstract: …the predictions of the discrete model converge to those of the continuum model. We use the continuum model to simulate the progression of the degenerative disease known as keratoconus, characterized by a localized bulging of the corneal shell. We assign a spatial distribution of damage (i. e., reduction of the stiffness) to the mechanical properties of the… ▽ More
Submitted 22 December, 2023; originally announced December 2023.
Comments: 32 pages, 8 figures
MSC Class: 35J57; 35Q74; 35Q92; 74E10; 74Gxx; 74L15; 74Q15; 92Cxx
arXiv:2311.01996 [pdf]
Detection of keratoconus Diseases using deep Learning
Abstract: One of the most serious corneal disorders, keratoconus is difficult to diagnose in its early stages and can result in blindness. This illness, which often appears in the second decade of life, affects people of all sexes and races. Convolutional neural networks (CNNs), one of the deep learning approaches, have recently come to light as particularly promising… ▽ More
Submitted 3 November, 2023; originally announced November 2023.
arXiv:2306.15018 [pdf]
Possible depth-resolved reconstruction of shear moduli in the cornea following collagen crosslinking (CXL) with optical coherence tomography and elastography
Abstract: Corneal collagen crosslinking (CXL) is commonly used to prevent or treat keratoconus. Although changes in corneal stiffness induced by CXL surgery can be monitored with non-contact dynamic optical coherence elastography (OCE) by tracking mechanical wave propagation, depth dependent changes are still unclear if the cornea is not crosslinked through the whole… ▽ More
Submitted 26 June, 2023; originally announced June 2023.
Comments: Submitted to Biomedical Optics Express on June 13th 2023, Manuscript ID: 497970 - Under Review. Manuscript, 10 pages / 6 figures / 2 tables. Supplementary, 7 pages / 4 figures
arXiv:2301.12037 [pdf]
Possible depth-resolved reconstruction of shear moduli in the cornea following collagen crosslinking (CXL) with optical coherence tomography and elastography
Abstract: Collagen crosslinking of the cornea (CXL) is commonly employed to prevent or treat keratoconus. Although the change of corneal stiffness induced by CXL surgery can be monitored with non-contact dynamic Optical Coherence Elastography (OCE) by tracking mechanical wave propagation, the depth dependence of this change is still unclear if the cornea is not crossl… ▽ More
Submitted 25 April, 2023; v1 submitted 27 January, 2023; originally announced January 2023.
Comments: Main: 10 Pages, 6 Figures Supplemental: 12 Pages, 3 Figures
arXiv:2209.11803 [pdf]
Compact orthogonal view OCT: clinical exploration of human trabecular meshwork and cornea at cell resolution
Abstract: …Future clinical adoption of the device is facilitated by the compact footprint and broad functionality that includes corneal imaging in healthy subjects and patients (with keratoconus, Fuchs endothelial dystrophy) using the same design. ▽ More
Submitted 12 September, 2022; originally announced September 2022.
Keratoconus Classifier for Smartphone-based Corneal Topographer
Abstract: Keratoconus is a severe eye disease that leads to deformation of the cornea. It impacts people aged 10-25 years and is the leading cause of blindness in that demography. Corneal topography is the gold standard for… ▽ More
Submitted 7 May, 2022; originally announced May 2022.
Comments: 4 pages
Multiscale mechanical model based on patient-specific geometry: application to early keratoconus development
Abstract: Keratoconus is a pathology of the cornea associated with a tissue thinning and a weakening of its mechanical properties. However, it remains elusive which aspect is the leading cause of the disease. To investigate this question, we combined a multiscale model with a patient-geometry in order to simulate the mechanical response of healthy and pathological cor… ▽ More
Submitted 24 November, 2021; originally announced November 2021.
SmartKC: Smartphone-based Corneal Topographer for Keratoconus Detection
Abstract: Keratoconus is a severe eye disease affecting the cornea (the clear, dome-shaped outer surface of the eye), causing it to become thin and develop a conical bulge. The diagnosis of… ▽ More
Submitted 21 January, 2022; v1 submitted 1 November, 2021; originally announced November 2021.
Comments: Change Log: + Fixed sim-K computation (updated Section 5.5.3); re-ran our pipeline with the updated sim-K values (updated Figure 7); + Conducted the comparative evaluation with doctors again (total 4 doctors), and got improved results (updated Section 7.2 and Table 2); [Note: This is an updated version of the paper that was accepted for publication in IMWUT 2021.]
arXiv:2107.08208 [pdf]
A new Method for the in vivo identification of material properties of the human eye. Feasibility analysis based on synthetic data
Abstract: …as reference. For this purpose, a finite element model of the human eye is constructed to synthetically generate displacement full-fields from different datasets with keratoconus-like degradations. Then, a new approach based on the equilibrium gap method (EGM) combined with a mechanical morphing approach is proposed and used to identify the material paramete… ▽ More
Submitted 17 July, 2021; originally announced July 2021.
Comments: 21 pages, 8 figures
arXiv:2006.10893 [pdf]
Nearly-incompressible transverse isotropy (NITI) of cornea elasticity: model and experiments with acoustic micro-tapping OCE
Abstract: …cornea provides the largest refractive power for the human visual system. Its stiffness, along with intraocular pressure (IOP), are linked to several pathologies, including keratoconus and glaucoma. Although mechanical tests can quantify corneal elasticity ex vivo, they cannot be used clinically. Optical coherence elastography (OCE), which launches and track… ▽ More
Submitted 18 June, 2020; originally announced June 2020.
Comments: 41 pages, 14 figures, including supplementary notes, JJP and MAK contributed equally to this work
arXiv:2005.13308 [pdf]
Non-invasive detection of nanoscale structural changes in cornea associated with cross-linking treatment
Abstract: …UVA irradiation with a riboflavin photosensitizer has grown from an interesting concept to a practical clinical treatment for corneal ectatic diseases globally, such as keratoconus. To characterize the corneal structural changes, existing methods such as X-ray microscopy, transmission electron microscopy (TEM), histology and optical coherence tomography have… ▽ More
Submitted 27 May, 2020; originally announced May 2020.
Comments: 25 pages, 10 figures
Deep Learning Based Unsupervised and Semi-supervised Classification for Keratoconus
Abstract: …the entry of light rays and controlling focusing the movement of the light within the eye. The cornea is critical, contributing to 75% of the refractive power of the eye. Keratoconus is a progressive and multifactorial corneal degenerative disease affecting 1 in 2000 individuals worldwide. Currently, there is no cure for… ▽ More
Submitted 30 January, 2020; originally announced January 2020.
Comments: 7 pages, 8 figures, 3 tables
MSC Class: 62F15; 47N30; 62P10; 92C50; 46N60; 92B20 ACM Class: I.2.6; I.2.1; J.3
arXiv:1901.01789 [pdf]
Keratoconus Recognition Using A Parameter Set Determined from IOP-Matched Scenario
Abstract: PURPOSE: Among the current practices for keratoconus recognition using biomechanical parameters from Corvis ST, matching intra-ocular pressure (IOP) is often required to eliminate the biasing influence; as a result, the combined biomechanical parameters determined from IOP-unmatched scenario possibly bring in confounding influence. This paper was therefore d… ▽ More
Submitted 7 January, 2019; originally announced January 2019.
arXiv:1901.01772 [pdf]
Evaluation of central corneal thickness in keratoconus and normal corneas during air puff indentation
Abstract: Purpose: This study aimed to investigate the actual changes of central corneal thickness (CCT) in keratoconus and normal corneas during air puff indentation, by using corneal visualization Scheimpflug technology (Corvis ST). Methods: A total of 32 keratoconic eyes and 46 normal eyes were included in this study. Three parameters of CCTinitial, CCTfinal and CC… ▽ More
Submitted 7 January, 2019; originally announced January 2019.
arXiv:1802.01055 [pdf]
Spatially-resolved Brillouin spectroscopy reveals biomechanical changes in early ectatic corneal disease and post-crosslinking in vivo
Abstract: Mounting evidence connects the biomechanical properties of tissues to the development of eye diseases such as keratoconus, a common disease in which the cornea thins and bulges into a conical shape. However, measuring biomechanical changes in vivo with sufficient sensitivity for disease detection has proved challenging. Here, we present a first large-scale s… ▽ More
Submitted 3 February, 2018; originally announced February 2018.
Comments: 39 pages, 8 main figures, supplementary information
An adaptive algorithm for the cornea modeling from keratometric data
Abstract: …and corneal power maps from the data collected by keratoscopes, such as the Placido rings based topographers, decisive for an early detection of corneal diseases such as keratoconus. Numerical experiments show that the algorithm exhibits a steady exponential error decay, independently of the level of aberration of the cornea. The complexity of each anisotr… ▽ More
Submitted 7 September, 2010; originally announced September 2010.
Comments: 19 pages, 9 figures
MSC Class: 65D15; 65Z05; 92C50; 92C55; 94A08
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