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Penetrating Keratoplasty versus Deep Anterior Lamellar Keratoplasty for Keratoconus: A Systematic Review and Meta-Analysis of 27,018 Eyes
A A. Awad, A M. Elettreby, A A. Abo Elnaga… - Seminars in Ophthalmology, 2025
… According to the aim of the work, we included studies directed towards patients
diagnosed with keratoconus who underwent DALK or PK; we included all
randomized controlled trials or observational studies that compare these two …
diagnosed with keratoconus who underwent DALK or PK; we included all
randomized controlled trials or observational studies that compare these two …
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Ethnicity optimized indices enhance the diagnostic efficiency of early Keratoconus: A multicenter validation study
Y Huo, R Xie, J Li, J Hou, H Zou, Y Wang - Contact Lens and Anterior Eye, 2025
Purpose This study aimed to evaluate the effectiveness of an ethnically-optimized
corneal tomography and biomechanics index using artificial intelligence (AI)
techniques for diagnosing early ectasia in Chinese populations and determine the …
corneal tomography and biomechanics index using artificial intelligence (AI)
techniques for diagnosing early ectasia in Chinese populations and determine the …
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Optical quality of the cornea one year after Cretan protocol plus in eyes with keratoconus
D Özkoyuncu Kocabaş, F Yavrum, K Özülken - Clinical and Experimental Optometry, 2025
… The clinical diagnosis of keratoconus was based on Sirius corneal topography.
Progressive keratoconus has been defined as the presence of at least one of the
following changes in the last year: an increase of ≥ 1.0 diopter (D) in the Kmax value …
Progressive keratoconus has been defined as the presence of at least one of the
following changes in the last year: an increase of ≥ 1.0 diopter (D) in the Kmax value …
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[HTML] Debunking myths about keratoconus
S Gromacki - 2025
I have been caring for patients with keratoconus (KC) for 30 years. During that time,
technology and the standard of care have improved. However, the nuances of early
diagnosis can still be tricky to understand. One way to address this is by debunking …
technology and the standard of care have improved. However, the nuances of early
diagnosis can still be tricky to understand. One way to address this is by debunking …
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[HTML] Climate Determinants of Keratoconus: Insights From a Systematic Review of Prevalence
H Shabani, J De Ridder, MA Asaad, WM Bramer… - … Ophthalmology & Visual …, 2025
Purpose: The reported prevalence of keratoconus varies widely worldwide, but the
causes of this variation are not well understood. We therefore aimed to explore the
potential impact of local climate variables on keratoconus prevalence. Methods: The …
causes of this variation are not well understood. We therefore aimed to explore the
potential impact of local climate variables on keratoconus prevalence. Methods: The …
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[PDF] Efficacy and Safety of Accelerated Transepithelial Corneal Crosslinking in Non-Pediatric Patients with Progressive Keratoconus: Insights from a Retrospective Cohort …
AC Chiraples, M Munteanu, HT Stanca, DM Darabus… - 2025
Background/Objectives: transepithelial accelerated corneal crosslinking (TE-ACXL)
is a minimally invasive approach for stabilizing progressive keratoconus while
preserving the corneal epithelium. This study aims to evaluate changes in visual …
is a minimally invasive approach for stabilizing progressive keratoconus while
preserving the corneal epithelium. This study aims to evaluate changes in visual …
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Evaluation of neutrophil–lymphocyte ratio, platelet–lymphocyte ratio, and mean platelet volume levels in pediatric keratoconus patients
MD Al-Mendalawi - Saudi Journal of Ophthalmology
… [1] reported that platelet–lymphocyte ratio (PLR) and mean platelet volume (MPV)
might be new biomarkers in evaluating keratoconus among … Consequently, the
clinical applicability of study results among Turkish pediatric keratoconus patients …
might be new biomarkers in evaluating keratoconus among … Consequently, the
clinical applicability of study results among Turkish pediatric keratoconus patients …
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[HTML] New technique for enhancing the astigmatic correction of intracorneal ring segments in keratoconus eyes with a central cone
Y Bteich, CJ Mehanna, MA Fattah, A Saad, R Antonios… - Saudi Journal of Ophthalmology
… Intrastromal corneal ring segments (ICRSs) have been used extensively in
patients with keratoconus. … We evaluate our new technique in a small case series
of eyes with keratoconus with central … Results were analyzed and compared to …
patients with keratoconus. … We evaluate our new technique in a small case series
of eyes with keratoconus with central … Results were analyzed and compared to …
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Extremely asymmetric ectasia: Tomographically unilateral keratoconus
H Shabani, WD Ramdas, MA Meester-Smoor… - Acta ophthalmologica
Purpose To investigate the characteristics of apparently stable forms of
tomographically unilateral keratoconus (KC). Methods In this retrospective case-control
study, strict unilaterality criteria were applied to select tomographically unilateral …
tomographically unilateral keratoconus (KC). Methods In this retrospective case-control
study, strict unilaterality criteria were applied to select tomographically unilateral …
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[HTML] Brown-McLean syndrome secondary keratoconus
Q Wan, L Chen, R Wei, Y Deng, K Ma, J Tang - BMC Ophthalmology, 2025
… Syndrome combined with bilateral keratoconus [6]. Observing the presence of
Brown-McLean Syndrome with keratoconus again in this … leading to deformation
under the pressure of the upper and lower eyelids, resulting in central protrusion …
Brown-McLean Syndrome with keratoconus again in this … leading to deformation
under the pressure of the upper and lower eyelids, resulting in central protrusion …
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A novel metric to monitor early progression in keratoconus: Epithelial backscatter
I Toprak, CE Gunes, C Martin-Seker, O Parca - 2025
Purpose To assess the progression of keratoconus over the course of one-year
using epithelia and anterior stromal backscatter, Belin ABCD progression display,
and various Pentacam® parameters and to determine whether backscatter …
using epithelia and anterior stromal backscatter, Belin ABCD progression display,
and various Pentacam® parameters and to determine whether backscatter …
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[HTML] Effect of selective suture removal on graft astigmatism after corneal transplantation in keratoconus
S Feizi, MA Javadi, Z Karjou, N Nouri, M Oraeeyazdani… - Therapeutic Advances in …, 2025
… We included all patients who underwent their initial corneal transplant for
keratoconus between February 25, 1994 and January 27, 2020 … Exclusion criteria
comprised preoperative corneal vascularization, additional ocular diseases besides …
keratoconus between February 25, 1994 and January 27, 2020 … Exclusion criteria
comprised preoperative corneal vascularization, additional ocular diseases besides …
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[PDF] Posterior chamber phakic intraocular lenses for correcting ametropia in stable keratoconus
O Berger, N Garikapati, H Naveed, A Hajjar-Sese… - Ophthalmic Research, 2025
Introduction: The use of posterior chamber phakic intraocular lenses are a
reasonable option in the armamentarium to treat refractive error in patients with
keratoconus. We present our experience with the use of posterior chamber phakic …
reasonable option in the armamentarium to treat refractive error in patients with
keratoconus. We present our experience with the use of posterior chamber phakic …
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[HTML] Keratoconus with two consecutive re-emergences: a case report
P Zhang, Y Wu, L Ma, D Wang - BMC ophthalmology, 2025
… emergence of keratoconus is due to chronic mechanical damage to the cornea [3].
For the first time, we reported a case of consecutive keratoconus recurrence after
two consecutive deep anterior lamellar keratoplasty(DALK). Our findings suggest …
For the first time, we reported a case of consecutive keratoconus recurrence after
two consecutive deep anterior lamellar keratoplasty(DALK). Our findings suggest …
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Can Chatbots Be Used for Keratoconus Patient Education?
OD Melissa Barnett - Contact Lens Spectrum, 2025
In most scleral lens practices, keratoconus (KC) is one of the top indications for
scleral lens fitting. In addition to correcting corneal irregularity and visual
improvement scleral lenses can delay or reduce the need for corneal transplantation …
scleral lens fitting. In addition to correcting corneal irregularity and visual
improvement scleral lenses can delay or reduce the need for corneal transplantation …
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[PDF] Sociodemographic predictors of acute corneal hydrops in patients with unstable keratoconus.
LN Kanu, N Boychev, M Fry, L Margolis, C Le… - medRxiv, 2025
… with unstable keratoconus. Design Retrospective case control study Subjects All
patients diagnosed with unstable keratoconus at Mass Eye … Results Of 762
patients diagnosed with unstable keratoconus, we identified 128 episodes of …
patients diagnosed with unstable keratoconus at Mass Eye … Results Of 762
patients diagnosed with unstable keratoconus, we identified 128 episodes of …
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[HTML] Molecular Subtype Identification and Potential Drug Prediction Based on Anoikis-Related Genes Expression in Keratoconus
Z Jiang, B Zhang, S Jia, X Yuan - Investigative Ophthalmology & Visual Science, 2025
Purpose: Anoikis is a special apoptosis accompanied by the loss of extracellular
matrix (ECM) environment and the decomposition of ECM is an important process in
the occurrence of keratoconus (KC). This study aims to describe the expression …
matrix (ECM) environment and the decomposition of ECM is an important process in
the occurrence of keratoconus (KC). This study aims to describe the expression …
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[HTML] Socioeconomic Factors Associated With Differential Access to Treatment in Patients With Keratoconus at a US Urban Safety-Net Hospital
OC Ihionu, JK Samra, RM Rashad, MA Arsiwala… - Cornea Open, 2025
… between ADI and keratoconus treatment access, we found lower rates of CXL and
CL treatment of keratoconus and worse severity on … Keratoconus is a progressive
corneal disease characterized by bulging and thinning of the cornea, a …
CL treatment of keratoconus and worse severity on … Keratoconus is a progressive
corneal disease characterized by bulging and thinning of the cornea, a …
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[HTML] Is there a relationship between keratoconus and diabetes?
A Chous - 2024
… of keratoconus in (predominantly type 2) diabetes without complications were 20%
less likely to occur, with a 52% lower odds of keratoconus … As for some reports
linking increased risk of keratoconus to diabetes, diabetes diagnosis came after the …
less likely to occur, with a 52% lower odds of keratoconus … As for some reports
linking increased risk of keratoconus to diabetes, diabetes diagnosis came after the …
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[PDF] DETECTION OF KERATOCONUS DISEASE DEPENDING ON CORNEAL TOPOGRAPHY USING DEEP LEARNING
AA Hashim, M Mazinani
… for keratoconus identification using corneal topography pictures. Images from 170
keratoconus patients, 28 subclinical keratoconus patients, … The datasets were
collected from more than 1900 keratoconus patients in the keratoconus center of the …
keratoconus patients, 28 subclinical keratoconus patients, … The datasets were
collected from more than 1900 keratoconus patients in the keratoconus center of the …
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[HTML] Coinfection of Herpes Simplex virus 2 and Mycobacterium chelonae in Acute Hydrops Associated with Keratoconus: A Case Report
P Marques-Couto, A Gama-Castro, T Carvalho… - IDCases, 2025
… Our hypothesis is that this complication of keratoconus disrupts the normal
corneal barrier function, thereby increasing the susceptibility to infections including
those caused by nontuberculous mycobacteria similar to what might be observed …
corneal barrier function, thereby increasing the susceptibility to infections including
those caused by nontuberculous mycobacteria similar to what might be observed …
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Sleeping Behavior and Keratoconus: A Scoping Review
A Tello, AP Navarro, A Pedraza-Concha, JV Sylvia… - Ceska a slovenska …, 2025
Aims This study was planned to explore the efficacy of autologous blood as a
stabilizing agent for graft surgery in pterygium. Material and methods For this
observational, non-comparative, interventional study, the hospital data of patients …
stabilizing agent for graft surgery in pterygium. Material and methods For this
observational, non-comparative, interventional study, the hospital data of patients …
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Evaluating the Influence of Eye Rubbing and Genetic Predisposition on Keratoconus in Bucaramanga (Colombia): A Case-control Study
ML Duarte-Bueno, A Tello, AL Diaz-Martínez… - Ceska a slovenska …, 2025
… Conclusion: Eye rubbing and family history of keratoconus were the most
important risk factors for keratoconus in our population. Although … of keratoconus.
Other factors, such as sun exposure, sleeping position, and atopy, may play a role in …
important risk factors for keratoconus in our population. Although … of keratoconus.
Other factors, such as sun exposure, sleeping position, and atopy, may play a role in …
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Enhancing early detection of keratoconus suspects using interocular corneal tomography asymmetry
S Li, Y Huo, R Xie, Y Han, H Zou, Y Wang - International Ophthalmology, 2025
… The global consensus on corneal ectasia is that it is a bilateral disease, and true
unilateral keratoconus does not exist [14]. We believe that bilateral asymmetry is a
key feature for the early diagnosis of keratoconus. Interocular asymmetries in clinical …
unilateral keratoconus does not exist [14]. We believe that bilateral asymmetry is a
key feature for the early diagnosis of keratoconus. Interocular asymmetries in clinical …
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[HTML] Accuracy of keratoconus-specific formulae compared to standard formulae for intraocular lens power calculation in patients with keratoconus
N Kahuam-López, JYM Ling, A Iovieno, SN Yeung - Canadian Journal of Ophthalmology
… -specific formulae would result in improved refractive outcomes compared with
standard formulae and a machine learning-based thick IOL calculation formula for
IOL power estimation in keratoconus in a large cohort of keratoconus patients who …
standard formulae and a machine learning-based thick IOL calculation formula for
IOL power estimation in keratoconus in a large cohort of keratoconus patients who …
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tomography asymmetry
S Li, Y Huo, R Xie, Y Han, H Zou, Y Wang - International Ophthalmology, 2025
… The global consensus on corneal ectasia is that it is a bilateral disease, and true
unilateral keratoconus does not exist [14]. We believe that bilateral asymmetry is a
key feature for the early diagnosis of keratoconus. Interocular asymmetries in clinical …
unilateral keratoconus does not exist [14]. We believe that bilateral asymmetry is a
key feature for the early diagnosis of keratoconus. Interocular asymmetries in clinical …
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[HTML] Accuracy of keratoconus-specific formulae compared to standard formulae for intraocular lens power calculation in patients with keratoconus
N Kahuam-López, JYM Ling, A Iovieno, SN Yeung - Canadian Journal of Ophthalmology
… -specific formulae would result in improved refractive outcomes compared with
standard formulae and a machine learning-based thick IOL calculation formula for
IOL power estimation in keratoconus in a large cohort of keratoconus patients who …
standard formulae and a machine learning-based thick IOL calculation formula for
IOL power estimation in keratoconus in a large cohort of keratoconus patients who …
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[HTML] Proteomics Reveals Mechanisms of Delayed Keratoconus Progression: A Study of Corneas Following Two Light-Activated Crosslinking Treatments
DHJ Vogels, J Brekelmans, R Mohren, NRN Vos… - … Ophthalmology & Visual …, 2025
Purpose: This study aims to elucidate on changes in biological pathways in rabbit
corneas induced by two methods of light-activated corneal stiffening: topical
application of riboflavin with dextran (RF-D) or WST11 with dextran (WST-D) …
corneas induced by two methods of light-activated corneal stiffening: topical
application of riboflavin with dextran (RF-D) or WST11 with dextran (WST-D) …
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[HTML] Corneal biomechanics: A diagnostic tool for differentiating high astigmatism and mild keratoconus
N Razak, WHWA Halim, B Mohd-Ali - African Vision and Eye Health, 2025
Background: High astigmatism (HA) can be misinterpreted as keratoconus (KCN), is
highly prone to developing KCN and is normally reconfirmed using corneal
topography. Aim: To determine the diagnostic value of corneal biomechanical …
highly prone to developing KCN and is normally reconfirmed using corneal
topography. Aim: To determine the diagnostic value of corneal biomechanical …
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[HTML] Diagnostic performance of corneal epithelium-and Bowman's layer thickness mapping in patients with unilateral Keratoconus
N Pircher, R Kilian, F Beer, R Donner, P Roberts… - Graefe's Archive for Clinical …, 2025
… Several publications have described cases of unilateral keratoconus (UKC),
where only one eye presents with clinical KC, whereas the fellow eye (FE) shows no
topographic signs of corneal ectasia [16, 18]. Since many of the FE will go on …
where only one eye presents with clinical KC, whereas the fellow eye (FE) shows no
topographic signs of corneal ectasia [16, 18]. Since many of the FE will go on …
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Self-reported prevalence and risk factors associated with keratoconus among the adult population of Trinidad and Tobago: a cross-sectional study
NE Ezinne, MA Kwarteng, KP Mashige, VR Moodley - International Ophthalmology, 2025
… Early screening for keratoconus in this country is strongly recommended to
facilitate prompt … across 15 countries estimated the global prevalence of
keratoconus to be 138 per 100,000 [8]. The … Keratoconus is one of the major …
facilitate prompt … across 15 countries estimated the global prevalence of
keratoconus to be 138 per 100,000 [8]. The … Keratoconus is one of the major …
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Corneal stromal cells from patients with keratoconus exhibit alterations in the ESCRT-dependent machinery responsible for multivesicular body formation
N Blanco-Agudín, S Ye, I Alcalde, MD Corte-Torres… - Experimental Eye Research, 2025
Previous studies have reported that exosomes produced by corneal stromal cells
from keratoconus patients exhibit a molecular content distinct from those produced
by cells from healthy donors. This study investigates differences in the expression of …
from keratoconus patients exhibit a molecular content distinct from those produced
by cells from healthy donors. This study investigates differences in the expression of …
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[PDF] Management of advanced keratoconus using a semi-scleral contact lens: A non-surgical option
ZA Rashid, VR Moodley, ZA Rashid
… CLs in a patient with advanced keratoconus. A 23-year-old female, referred for CL
fitting, presented with advanced keratoconus with minimal … report shows that semi-scleral
CLs provide a satisfactory, non-surgical alternative to improve VA in patients with …
fitting, presented with advanced keratoconus with minimal … report shows that semi-scleral
CLs provide a satisfactory, non-surgical alternative to improve VA in patients with …
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[HTML] Topographic Pattern-Based Nomogram to Guide Keraring Implantation in Eyes with Mild to Moderate Keratoconus: Visual and Refractive Outcome
U de Sanctis, P Caselgrandi, C Gennaro, C Tosi… - Journal of Clinical Medicine, 2025
Background: To assess the outcome of Keraring (Mediphacos, Brazil) implantation
according to a topographic pattern-based nomogram in eyes with mild to moderate
keratoconus. Materials and Methods: A topographic pattern-based nomogram was …
according to a topographic pattern-based nomogram in eyes with mild to moderate
keratoconus. Materials and Methods: A topographic pattern-based nomogram was …
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[HTML] Different keratoconus definitions can lead to substantial prevalence disparities in population-based studies
H Shabani, BTH van Dooren, MA Meester-Smoor… - Scientific Reports, 2025
… This report explores the prevalence of keratoconus in a population-based cohort
of adults aged 40 or older according to ten different … Suspected keratoconus was
defined as having at least one eye with a final D-index (BAD-D) ≥ 2.6. Manifest …
of adults aged 40 or older according to ten different … Suspected keratoconus was
defined as having at least one eye with a final D-index (BAD-D) ≥ 2.6. Manifest …
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[HTML] The cellular response of lipopolysaccharide-induced inflammation in keratoconus human corneal fibroblasts to RB-PDT: Insights into cytokines, chemokines and …
N Chai, T Stachon, S Häcker, T Berger, Z Li, M Amini… - PloS one, 2025
Purpose Rose Bengal Photodynamic Therapy (RB-PDT) offers dual therapeutic
benefits by enhancing corneal stiffness and providing antibacterial activity,
presenting significant potential for patients with keratoconus complicated by keratitis …
benefits by enhancing corneal stiffness and providing antibacterial activity,
presenting significant potential for patients with keratoconus complicated by keratitis …
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[HTML] Distinct Ocular Surface Microbiome in Keratoconus Patients Correlate With Local Immune Dysregulation
NR Kumar, P Khamar, R Kannan, A Padmanabhan… - … Ophthalmology & Visual …, 2025
Purpose: Keratoconus (KC) is characterized by irregular astigmatism along with
corneal stromal weakness and is associated with altered immune status. Tissue
resident microbiomes are known to influence the immune status in other organs, but …
corneal stromal weakness and is associated with altered immune status. Tissue
resident microbiomes are known to influence the immune status in other organs, but …
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Advanced Keratoconus with Hydrops: Light at the End of the Tunnel
K Bhardwaj, T Chauhan, S Vohra, G Dabas… - Resolving Dilemmas in …, 2025
The rupture of the Descemet membrane in an acute setting leads to a condition
called acute corneal hydrops. While its incidence is low, it can be encountered in
those with weakened and thin corneas such as those with advanced keratoconus …
called acute corneal hydrops. While its incidence is low, it can be encountered in
those with weakened and thin corneas such as those with advanced keratoconus …
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A Stitch in Time Saves Nine: Optic Neuritis in a Keratoconus Patient
S Monga - … in Ophthalmology: Challenging Cases, Diagnosis and …, 2025
This chapter narrates the experience of managing a severe visual deficit due to
atypical optic neuritis, in a middle-aged male who was a known case of keratoconus.
The emphasis is on the importance of good clinical examination to elucidate the …
atypical optic neuritis, in a middle-aged male who was a known case of keratoconus.
The emphasis is on the importance of good clinical examination to elucidate the …
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Keratoconus staging, monitoring & corvis biomechanical analysis
E Flockerzi, B Seitz - Acta Ophthalmologica, 2025
… reported to enable distinction between healthy and keratoconus corneas. The
main Corneal Visualization … keratoconus corneas in a quasi‐binary manner,
whereas the Biomechanical E‐Staging is based on the linear term of the CBI and …
main Corneal Visualization … keratoconus corneas in a quasi‐binary manner,
whereas the Biomechanical E‐Staging is based on the linear term of the CBI and …
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Gene expression profiling of oxidative and anti‐oxidative genes in keratoconus patients
S Sharma, L Singh, S Kashyap, S Sen, N Sharma - Acta Ophthalmologica, 2025
Aims/Purpose: Keratoconus (KC) is thinning of corneal stroma & irregular
astigmatism, resulting in diminution of vision. Despite its prevalence, the underlying
etiology is poorly understood. Emerging evidence suggests a dysregulation of …
astigmatism, resulting in diminution of vision. Despite its prevalence, the underlying
etiology is poorly understood. Emerging evidence suggests a dysregulation of …
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Topographic determinants of anterior chamber angle narrowing in patients with keratoconus
P Nabovati, H Soltan‐Dehghan, A Farzaneh… - Acta Ophthalmologica, 2025
… visited a tertiary eye hospital and were diagnosed with keratoconus, were
recruited for this study. First… The keratoconus was diagnosed based on distorted
keratometric mires, scissoring of … with keratoconus as well as the presence of at …
recruited for this study. First… The keratoconus was diagnosed based on distorted
keratometric mires, scissoring of … with keratoconus as well as the presence of at …
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[PDF] Managing Bilateral Vernal Keratoconjunctivitis, Keratoconus, and Steroid-Induced Glaucoma: A Threefold Struggle
NH Maffar, Y Azhany, NASM Ghazali, J Muhammed… - Cureus, 2025
… In this case report, we present a young Malay girl with VKC complicated by
progressive keratoconus and steroid-induced glaucoma, … 2), and marked
progression of keratoconus with thin corneal thickness in the right eye and minimal …
progressive keratoconus and steroid-induced glaucoma, … 2), and marked
progression of keratoconus with thin corneal thickness in the right eye and minimal …
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Optimizing keratoconus treatment with AI‐driven lenticule matching using pentacam indices
F Doroodgar, S Niazi, H Nematy - Acta Ophthalmologica, 2025
Aims/Purpose: The aim of this study is to develop an advanced artificial intelligence (AI)
methodology to optimize the matching of donor and recipient lenticules for the
treatment of keratoconus. This approach leverages Pentacam indices related to …
methodology to optimize the matching of donor and recipient lenticules for the
treatment of keratoconus. This approach leverages Pentacam indices related to …
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Vitamin D supplementation modifies clinical and biological markers of keratoconus progression
G Ferrari, S Palombella, N Bartolomeo, G Tilaro… - Acta Ophthalmologica, 2025
Aims/Purpose: evaluation of vitamin D (Vit D) supplementation on clinical
progression and systemic biomarkers in adolescent patients affected by keratoconus
(KC) and Vit D insufficiency. Methods: forty adolescent patients (age range: 12–19) …
progression and systemic biomarkers in adolescent patients affected by keratoconus
(KC) and Vit D insufficiency. Methods: forty adolescent patients (age range: 12–19) …
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Computational and experimental mechanical characterization of a novel corneal implant for the treatment of keratoconus
GM Ragonese, D Carbonaro, S Zambon, E Villa… - Acta Ophthalmologica, 2025
Aims/Purpose: Current treatment options of keratoconus have several limitations.
These limitations have been addressed by developing a novel nitinol GROSSO®
implant, that restores the physiological curvature of the cornea by virtue of a dome‐shaped …
These limitations have been addressed by developing a novel nitinol GROSSO®
implant, that restores the physiological curvature of the cornea by virtue of a dome‐shaped …
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Understanding structural changes in keratoconus: Anterior scleral and choroidal thickness analysis using swept source optical coherence tomography
A Hassairi, C Ahmed, O Mehdi, R Limaiem - Acta Ophthalmologica, 2025
Aims/Purpose: The study aims to investigate the anterior scleral thickness (AST)
profile and choroidal thickness (CT) variations in keratoconus (KC) patients
compared to healthy controls, with the objective of providing a comprehensive …
profile and choroidal thickness (CT) variations in keratoconus (KC) patients
compared to healthy controls, with the objective of providing a comprehensive …
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Tear proteomics for the understanding of corneal biomechanical weakness in offspring of keratoconus patients
M López‐López, T Alvite‐Piñeiro, Y Pastoriza, I Lema… - Acta Ophthalmologica, 2025
Aim: To analyze the tear proteome of offspring of keratoconus patients (O‐KC) to
elucidate the molecular mechanisms involved in corneal weakening in high‐risk
individuals. Methods: 80 O‐KC young participants matched with 42 control subjects …
elucidate the molecular mechanisms involved in corneal weakening in high‐risk
individuals. Methods: 80 O‐KC young participants matched with 42 control subjects …
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Intraocular lens power calculation in cataract patients with keratoconus: Bayesian network meta-analysis
ZY Tian, M Li, JS Zhang, YY Mao, ZX Guo, X Zheng… - International Ophthalmology, 2025
… for keratoconus predicted posterior corneal astigmatism (Barrett KC P-PCA),
EVO2. 0, and Barrett True-K formula for keratoconus measured … In the range of±1.00
D, the top three formulas were Barrett KC P-PCA, Barrett KC M-PCA and Kane for …
EVO2. 0, and Barrett True-K formula for keratoconus measured … In the range of±1.00
D, the top three formulas were Barrett KC P-PCA, Barrett KC M-PCA and Kane for …
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[HTML] Ineffectiveness of KeraVio Treatment with Violet Light-Emitting Glasses Without Riboflavin Drops for Progressive Keratoconus
H Kobashi, T Kumanomido, T Ide, N Kato, J Shimazaki… - Journal of Clinical Medicine, 2025
… This study aimed to report the clinical outcomes of KeraVio with VL irradiation
without the administration of riboflavin drops in patients with progressive keratoconus. …
This may suggest that KeraVio treatment with VL alone was not effective in preventing …
without the administration of riboflavin drops in patients with progressive keratoconus. …
This may suggest that KeraVio treatment with VL alone was not effective in preventing …
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[HTML] Mechanical Strain of Corneal Epithelium Influences the Expression of Genes Implicated in Keratoconus
L Moon, P Kaur, J Wang, A Sodhi, C Eberhart… - … Ophthalmology & Visual …, 2025
… Here, we set out to determine how eye rubbing can influence keratoconus
progression by exploring the expression of known disease … in keratoconus
corneal epithelium. Both proteins have also been reported to be markedly reduced …
progression by exploring the expression of known disease … in keratoconus
corneal epithelium. Both proteins have also been reported to be markedly reduced …
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[PDF] Successful Management of a Keratoconus Patient With Rarely Used Large-Diameter Corneal RGP Contact Lenses: A Case Report
A Almaweri - Cureus, 2025
… a keratoconus patient with infrequently used large-diameter corneal RGP contact
lenses. This method of fitting provides remarkable stability and patient comfort. Here,
I describe a case of a 39-year-old man with a known history of keratoconus… in the …
lenses. This method of fitting provides remarkable stability and patient comfort. Here,
I describe a case of a 39-year-old man with a known history of keratoconus… in the …
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Spatial Transcriptomics and Single-Cell RNA-Sequencing Revealed Dendritic Cell-Mediated Inflammation in Keratoconus
S Luo, J Li, Y Yang, Y Jiang, Y Jie, W Ge - The Ocular Surface, 2025
Keratoconus (KC) is a corneal disorder characterized by central corneal protrusion
and thinning. In this study, spatial transcriptomics was employed to investigate
molecular and cellular variations in KC, revealing a distinct pattern of inflammatory …
and thinning. In this study, spatial transcriptomics was employed to investigate
molecular and cellular variations in KC, revealing a distinct pattern of inflammatory …
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[HTML] Topographic factors associated with anterior chamber angle narrowing in patients with keratoconus
H Soltan-Dehghan, A Farzaneh, H Hashemi… - International Journal of …, 2025
AIM To identify topographic determinants of the anterior chamber angle (ACA) in
patients with keratoconus (KCN). METHODS Four hundred and ten eyes of 294
patients with KCN were recruited for this study. First, complete ocular examinations …
patients with keratoconus (KCN). METHODS Four hundred and ten eyes of 294
patients with KCN were recruited for this study. First, complete ocular examinations …
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[HTML] Retinal thickness and vascular density changes in Keratoconus: A systematic review and meta-analysis
H Vahedi, M Abdollahi, R Moshfeghinia, S Emami… - Heliyon, 2025
Purpose This systematic review and meta-analysis aimed to assess the changes in
retinal layer thickness and vascular density in patients diagnosed with keratoconus (KC).
Methods We conducted a thorough search in PubMed, Scopus, Embase, and Web …
retinal layer thickness and vascular density in patients diagnosed with keratoconus (KC).
Methods We conducted a thorough search in PubMed, Scopus, Embase, and Web …
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[HTML] Corneal hydrops secondary to advanced keratoconus. Published online August 8, 2019
A Tharayil, N Gaines - Consultant
… , have a higher risk of developing keratoconus. Pediatric keratoconus tends to be
more aggressive than adult keratoconus, and although it usually … However, with
pediatric keratoconus, the diagnosis often is not made until the disease has …
more aggressive than adult keratoconus, and although it usually … However, with
pediatric keratoconus, the diagnosis often is not made until the disease has …
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[HTML] Prevalence of keratoconus and keratoconus suspect, and their characteristics on corneal tomography in a population-based study
H Namba, N Maeda, H Utsunomiya, Y Kaneko… - PLOS ONE, 2025
Keratoconus (KC) is a progressive corneal disorder resulting in severe visual
impairment. We aimed to determine the prevalence and corneal tomographic
characteristics of KC and keratoconus suspect (KCS) in a population-based study …
impairment. We aimed to determine the prevalence and corneal tomographic
characteristics of KC and keratoconus suspect (KCS) in a population-based study …
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Assessment of Awareness of Keratoconus and its Relation to Eye Rubbing Among Saudi Arabia Population Supervisor/Primary Investigator
NA Alqasimi, LH Aljohani, R Ambrósio Jr, B AlQahtani… - Frontiers in Ophthalmology
Keratoconus (KC) is a bilateral, asymmetric, progressive thinning of the cornea that
causes a decrease in optical quality due to induced myopia, irregular astigmatism,
and higher-order aberrations.Keratoconus affects 1.38 per 1,000 individuals globally …
causes a decrease in optical quality due to induced myopia, irregular astigmatism,
and higher-order aberrations.Keratoconus affects 1.38 per 1,000 individuals globally …
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[PDF] Case Study: Optical Rehabilitation Remedies for a Patient with Keratoconus and Esophoria with Biochemical Aspects
AIA Al Ibrahim, AMA Aboalqasim, LA Namazi… - 2024
… Keratoconus and esophoria are eye disorders associated with eye alignment that
affect children and teenagers. However, keratoconus may not be noticed at a tender
age, while esophoria can be identified early in childhood. Keratoconus results from …
affect children and teenagers. However, keratoconus may not be noticed at a tender
age, while esophoria can be identified early in childhood. Keratoconus results from …
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[PDF] VISUAL OUTCOME OF SIMULTANEOUS PHOTOREFRACTIVE KERATECTOMY AND CORNEAL COLLAGEN CROSS LINKING (PRK CXL) IN KERATOCONUS …
A Ahmed, A Alaskary, S Ahmed
… treatments for keratoconus. The therapy for keratoconus is dependent upon the
illness severity and the degree of disease progression [3]. Eyeglasses and rigid gas
permeability contact lenses are traditional techniques for treating mild to moderate …
illness severity and the degree of disease progression [3]. Eyeglasses and rigid gas
permeability contact lenses are traditional techniques for treating mild to moderate …
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[PDF] Case Study: Optical Rehabilitation Remedies for a Patient with Keratoconus and Esophoria with Biochemical Aspects
AIA Al Ibrahim, AMA Aboalqasim, LA Namazi… - 2024
… Keratoconus and esophoria are eye disorders associated with eye alignment that
affect children and teenagers. However, keratoconus may not be noticed at a tender
age, while esophoria can be identified early in childhood. Keratoconus results from …
affect children and teenagers. However, keratoconus may not be noticed at a tender
age, while esophoria can be identified early in childhood. Keratoconus results from …
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[PDF] VISUAL OUTCOME OF SIMULTANEOUS PHOTOREFRACTIVE KERATECTOMY AND CORNEAL COLLAGEN CROSS LINKING (PRK CXL) IN KERATOCONUS …
A Ahmed, A Alaskary, S Ahmed
… treatments for keratoconus. The therapy for keratoconus is dependent upon the
illness severity and the degree of disease progression [3]. Eyeglasses and rigid gas
permeability contact lenses are traditional techniques for treating mild to moderate …
illness severity and the degree of disease progression [3]. Eyeglasses and rigid gas
permeability contact lenses are traditional techniques for treating mild to moderate …
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[HTML] Strategies for Early Keratoconus Diagnosis: A Narrative Review of Evaluating Affordable and Effective Detection Techniques
A Gideon Abou Said, J Gispets, E Shneor - Journal of Clinical Medicine, 2025
Keratoconus is a progressive corneal disorder that can lead to irreversible visual …
These technologies are essential for identifying early-stage keratoconus, yet their
high cost limits … ensure accurate and effective detection of early keratoconus. This …
These technologies are essential for identifying early-stage keratoconus, yet their
high cost limits … ensure accurate and effective detection of early keratoconus. This …
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[HTML] Repeatability of Pentacam HR in Keratoconus According to Two Different Scan Protocols: 25-3D Scan and 50-Cornea Fine
D Romano, G Coco, A Borgia, S Calza, S Kaye… - Journal of Clinical Medicine, 2025
Background: This study aims to evaluate the repeatability of the Pentacam HR,
comparing two different measurement modes (50-cornea fine and 25-3D scan) in
patients affected by keratoconus. Methods: Multicenter retrospective study …
comparing two different measurement modes (50-cornea fine and 25-3D scan) in
patients affected by keratoconus. Methods: Multicenter retrospective study …
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Keratoconus classification
AN Jinabhai - Optician, 2024
… ECPs typically find it relatively straightforward to identify moderate to severe
keratoconus, due to its classical topographical appearance (outlined later in this article)
and characteristic clinical signs. These clinical signs include: … The purpose of this …
keratoconus, due to its classical topographical appearance (outlined later in this article)
and characteristic clinical signs. These clinical signs include: … The purpose of this …
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[PDF] Long-Term Effectiveness of Scleral Lens Treatment in the Management of Keratoconus: A Systematic Review
A Mushtaq, I Alvi - Cureus, 2025
This systematic review evaluates the long-term effectiveness of scleral lenses in
improving visual outcomes, patient satisfaction, and safety in patients with
keratoconus. A systematic search of six databases (PubMed, Embase, Web of …
improving visual outcomes, patient satisfaction, and safety in patients with
keratoconus. A systematic search of six databases (PubMed, Embase, Web of …
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Non-genetic risk factors for keratoconus and its progression
IMY Cheung, L Angelo, A Gokul, M Ziaei - Clinical and Experimental Optometry, 2025
Keratoconus is a multifaceted corneal ectatic disorder characterized by a range of
genetic and environmental risk factors. While genetic predisposition significantly
influences global disease prevalence rates as well as severity and progression rates …
genetic and environmental risk factors. While genetic predisposition significantly
influences global disease prevalence rates as well as severity and progression rates …
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[HTML] Whole-genome sequencing identifies novel loci for keratoconus and facilitates risk stratification in a Han Chinese population
Y Yao, X Li, L Wu, J Zhang, Y Gui, X Yu, Y Zhou, X Li… - Eye and Vision, 2025
Background Keratoconus (KC) is a prevalent corneal condition with a modest
genetic basis. Recent studies have reported significant genetic associations in multi-ethnic
cohorts. However, the situation in the Chinese population remains unknown. This …
genetic basis. Recent studies have reported significant genetic associations in multi-ethnic
cohorts. However, the situation in the Chinese population remains unknown. This …
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Correction: Computational approaches for identifications of altered ion channels in keratoconus
KB Gaikwad, JS Babu, KTS Parthasarathi, J Narayanan… - Eye (London, England), 2025
Correction: Computational approaches for identifications of altered ion channels in
keratoconus Correction: Computational approaches for identifications of altered ion
channels in keratoconus Eye (Lond). 2025 Jan 2. doi: 10.1038/s41433-024-03493-4 …
keratoconus Correction: Computational approaches for identifications of altered ion
channels in keratoconus Eye (Lond). 2025 Jan 2. doi: 10.1038/s41433-024-03493-4 …
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Correction: Computational approaches for identifications of altered ion channels in keratoconus
KB Gaikwad, JS Babu, KTS Parthasarathi, J Narayanan… - Eye (London, England), 2025
Correction: Computational approaches for identifications of altered ion channels in
keratoconus Correction: Computational approaches for identifications of altered ion
channels in keratoconus Eye (Lond). 2025 Jan 2. doi: 10.1038/s41433-024-03493-4 …
keratoconus Correction: Computational approaches for identifications of altered ion
channels in keratoconus Eye (Lond). 2025 Jan 2. doi: 10.1038/s41433-024-03493-4 …
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Keratoconus in children in Tunisia: Epidemiological, clinical and therapeutic features
S Kammoun, K Maaloul, M Rekik, K Chaabouni…
Methods: Retrospective study focusing on patients aged less than 18 years,
presenting with KC and followed in a tertiary reference center in Sfax, Tunisia.
Results: Our study involved 38 eyes of 20 children. We found a mean age of 12.8 …
presenting with KC and followed in a tertiary reference center in Sfax, Tunisia.
Results: Our study involved 38 eyes of 20 children. We found a mean age of 12.8 …
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Comfort in Keratoconus
Z Tajbakhsh - Journal of Ophthalmic and Vision Research, 2024
Purpose: To compare rigid gas permeable (RGP) contact lens comfort in patients
with keratoconus who underwent corneal cross-linking (CXL) versus those without
CXL surgery. Methods: This prospective study was carried out on 41 eyes (25 …
with keratoconus who underwent corneal cross-linking (CXL) versus those without
CXL surgery. Methods: This prospective study was carried out on 41 eyes (25 …
SD Joshi, NV Gundecha - Journal of Clinical Ophthalmology and Research, 2025
Purpose: The purpose of this study was to describe the refractive outcomes and finer
aspects of visual acuity such as contrast, aberrations, and quality of vision after
keratoplasty for keratoconus. Design: This was a longitudinal clinical study of 50 …
aspects of visual acuity such as contrast, aberrations, and quality of vision after
keratoplasty for keratoconus. Design: This was a longitudinal clinical study of 50 …
MΜΛΝ Lubbad - 2024
… relevant corneal shape parameters for accurate keratoconus diagnosis. The study
raises questions about the necessary corneal shape indexes for precise
keratoconus diagnosis and the significance of specific corneal shape parameters for …
raises questions about the necessary corneal shape indexes for precise
keratoconus diagnosis and the significance of specific corneal shape parameters for …
Z Özer Özcan, M Berhuni, A Mete, K Güngör - Kocaeli Medical Journal
METHODS: The word "keratoconus" was searched in the Web of Science database.
The articles published in ophthalmology journals between 2010 and 2020 were
filtered. The traditional metric and altmetric data of the most cited 100 articles were …
The articles published in ophthalmology journals between 2010 and 2020 were
filtered. The traditional metric and altmetric data of the most cited 100 articles were …
AIA Al Ibrahim, AMA Aboalqasim, LA Namazi… - Egyptian Journal of …, 2024
… Keratoconus and esophoria are eye disorders associated with eye alignment that
affect children and teenagers. However, keratoconus may not be noticed at a tender
age, while esophoria can be identified early in childhood. Keratoconus results from …
affect children and teenagers. However, keratoconus may not be noticed at a tender
age, while esophoria can be identified early in childhood. Keratoconus results from …
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[PDF] Implantation of 320˚-Arc Length Intrastromal Corneal Ring Segments in Keratoconus, A prospective study
MA El-Malah, MMA Ibrahim, HME El Ghoneimy… - Al-Azhar International …, 2024
… The purpose of this study is to assess the clinical results in keratoconus patients'
eyes … both central and paracentral steepening in keratoconus patterns with low or
high topographic … history of any corneal abnormalities other than keratoconus (KC) …
eyes … both central and paracentral steepening in keratoconus patterns with low or
high topographic … history of any corneal abnormalities other than keratoconus (KC) …
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