[HTML] Corneal Topography–a Review of Available Investigation Methods and Impact in the Diagnosis and Follow-Up of Keratoconus
D Maria-Silvia, MC MARINESCU, CG CORBU… - Mædica, 2025… keratoconus or suspected of keratoconus. Depending on the displayed values,
we can determine if the cornea does not … keratoconus (KSI is below 15%), if there
is suspicion of keratoconus (KSI varies between 15 and 30%) and in the case of …
D Maria-Silvia, MC MARINESCU, CG CORBU… - Mædica, 2025
… keratoconus or suspected of keratoconus. Depending on the displayed values,
we can determine if the cornea does not … keratoconus (KSI is below 15%), if there
is suspicion of keratoconus (KSI varies between 15 and 30%) and in the case of …
we can determine if the cornea does not … keratoconus (KSI is below 15%), if there
is suspicion of keratoconus (KSI varies between 15 and 30%) and in the case of …
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Delayed corneal haze after combined photorefractive keratectomy and corneal cross-linking in non-keratoconus patients
M Atighehchian, F Alipour, H Ghanbari… - International Ophthalmology, 2025… This is a retrospective cohort study on patients without keratoconus underwent
simultaneous CXL-PRK. Uncorrected visual acuity (UCVA), best corrected visual acuity
(BCVA), manifest refraction, corneal keratometry, and corneal haze were evaluated. …
M Atighehchian, F Alipour, H Ghanbari… - International Ophthalmology, 2025
… This is a retrospective cohort study on patients without keratoconus underwent
simultaneous CXL-PRK. Uncorrected visual acuity (UCVA), best corrected visual acuity
(BCVA), manifest refraction, corneal keratometry, and corneal haze were evaluated. …
simultaneous CXL-PRK. Uncorrected visual acuity (UCVA), best corrected visual acuity
(BCVA), manifest refraction, corneal keratometry, and corneal haze were evaluated. …
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Assessment of Choroidal Vascularity and Thickness After Corneal Crosslinking Treatment in Keratoconus
H Kızıltoprak, B Ören, DO Kocabas, K Tekin - 2025… with keratoconus, it has been reported that CT is higher in keratoconus patients
than in the normal population [18–20]. Keratoconus is … However, some studies
suggest that increased cytokine and IgE levels in patients with keratoconus may be …
H Kızıltoprak, B Ören, DO Kocabas, K Tekin - 2025
… with keratoconus, it has been reported that CT is higher in keratoconus patients
than in the normal population [18–20]. Keratoconus is … However, some studies
suggest that increased cytokine and IgE levels in patients with keratoconus may be …
than in the normal population [18–20]. Keratoconus is … However, some studies
suggest that increased cytokine and IgE levels in patients with keratoconus may be …
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[HTML] Refractive Outcomes in Keratoconus Patients Following Toric Lens Implantation: A Systematic Review and Single-Group Meta-Analysis
TG Tan, K O'Kane, HW Roberts - Life, 2025… This systematic review and meta-analysis evaluated refractive outcomes, particularly
astigmatic correction, in keratoconus following toric intraocular lens (tIOL) implantation.
A systematic search identified eligible studies reporting pre- and postoperative …
TG Tan, K O'Kane, HW Roberts - Life, 2025
… This systematic review and meta-analysis evaluated refractive outcomes, particularly
astigmatic correction, in keratoconus following toric intraocular lens (tIOL) implantation.
A systematic search identified eligible studies reporting pre- and postoperative …
astigmatic correction, in keratoconus following toric intraocular lens (tIOL) implantation.
A systematic search identified eligible studies reporting pre- and postoperative …
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[HTML] Clinical Outcomes of Repeated Corneal Crosslinking for Progressive Keratoconus After Failure of Primary Procedure; Safety and Efficacy at 12-Month Follow-Up
M Elalfy, E Chatzimichail, K Mahgoub, A Hajjar-Sese… - Ophthalmology and Therapy, 2025Introduction This study aims to evaluate the efficacy and safety of repeated corneal
cross-linking (CXL) in patients with progressive keratoconus who have undergone
an unsuccessful primary epithelium-off (epi-off) CXL procedure. Additionally, it …
M Elalfy, E Chatzimichail, K Mahgoub, A Hajjar-Sese… - Ophthalmology and Therapy, 2025
Introduction This study aims to evaluate the efficacy and safety of repeated corneal
cross-linking (CXL) in patients with progressive keratoconus who have undergone
an unsuccessful primary epithelium-off (epi-off) CXL procedure. Additionally, it …
cross-linking (CXL) in patients with progressive keratoconus who have undergone
an unsuccessful primary epithelium-off (epi-off) CXL procedure. Additionally, it …
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[HTML] Characteristics of corneal biomechanical parameters and corneal thickness measured by Corvis ST and AS-OCT in progressive keratoconus treated by accelerated …
L Wei, T Qi, L Luo, Q Shi, S Mi, C Pei - Photodiagnosis and Photodynamic Therapy, 2025Purpose To explore the characteristics of corneal biomechanical parameters and
corneal thickness in different corneal regions in progressive keratoconus treated by
accelerated "epithelium off" cross-linking (A-CXL) surgery. Methods This is a …
L Wei, T Qi, L Luo, Q Shi, S Mi, C Pei - Photodiagnosis and Photodynamic Therapy, 2025
Purpose To explore the characteristics of corneal biomechanical parameters and
corneal thickness in different corneal regions in progressive keratoconus treated by
accelerated "epithelium off" cross-linking (A-CXL) surgery. Methods This is a …
corneal thickness in different corneal regions in progressive keratoconus treated by
accelerated "epithelium off" cross-linking (A-CXL) surgery. Methods This is a …
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[PDF] Efficacy and Safety of KeraVio Using Violet Light-Emitting Glasses and Cyanocobalamin Drops for Progressive Keratoconus: A Pilot Study
H Kobashi, K Tsubota, I Toda - 2025Purpose: To evaluate the efficacy and safety of KeraVio treatment, a minimally
invasive corneal cross-linking technique that combines cyanocobalamin eye drops
with violet light (VL) irradiation, in patients with progressive keratoconus. Methods …
H Kobashi, K Tsubota, I Toda - 2025
Purpose: To evaluate the efficacy and safety of KeraVio treatment, a minimally
invasive corneal cross-linking technique that combines cyanocobalamin eye drops
with violet light (VL) irradiation, in patients with progressive keratoconus. Methods …
invasive corneal cross-linking technique that combines cyanocobalamin eye drops
with violet light (VL) irradiation, in patients with progressive keratoconus. Methods …
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[HTML] Retinal and choroidal changes following corneal collagen cross-linking in keratoconus: a systematic review and meta-analysis of OCT and OCTA studies
K Bayat, A Seraj, P Pooyan, S Feizi, MR Kanavi… - International Journal of …, 2025Corneal collagen cross-linking (CXL) is widely used to halt the progression of
keratoconus by biomechanically strengthening the corneal stroma; however, its
potential effects on retina and choroid remain unclear. This systematic review and …
K Bayat, A Seraj, P Pooyan, S Feizi, MR Kanavi… - International Journal of …, 2025
Corneal collagen cross-linking (CXL) is widely used to halt the progression of
keratoconus by biomechanically strengthening the corneal stroma; however, its
potential effects on retina and choroid remain unclear. This systematic review and …
keratoconus by biomechanically strengthening the corneal stroma; however, its
potential effects on retina and choroid remain unclear. This systematic review and …
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[HTML] Contribution and Compensation Effects of Refracting Components to Ocular Aberrations in Keratoconus
SK Gupta, A Carkeet, SA Read, SJ Vincent… - … Ophthalmology & Visual …, 2025Purpose: The purpose of this study was to determine the (i) contributions of
refracting components to ocular aberrations and (ii) compensation effects exhibited
by these components in keratoconus. Methods: Right eyes of 14 keratoconus and 20 …
SK Gupta, A Carkeet, SA Read, SJ Vincent… - … Ophthalmology & Visual …, 2025
Purpose: The purpose of this study was to determine the (i) contributions of
refracting components to ocular aberrations and (ii) compensation effects exhibited
by these components in keratoconus. Methods: Right eyes of 14 keratoconus and 20 …
refracting components to ocular aberrations and (ii) compensation effects exhibited
by these components in keratoconus. Methods: Right eyes of 14 keratoconus and 20 …
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Wearable sensor-based eye-rubbing monitoring: a hybrid CNN-attentionrub architecture for keratoconus prevention
A Louja, I Drira, A Jamali, N Naja, L Sliman - The Journal of Supercomputing, 2025Eye rubbing constitutes a primary modifiable risk factor for keratoconus progression
and post-refractive surgery ectasia. Current automated detection systems using
single-paradigm architectures exhibit suboptimal performance in capturing complex …
A Louja, I Drira, A Jamali, N Naja, L Sliman - The Journal of Supercomputing, 2025
Eye rubbing constitutes a primary modifiable risk factor for keratoconus progression
and post-refractive surgery ectasia. Current automated detection systems using
single-paradigm architectures exhibit suboptimal performance in capturing complex …
and post-refractive surgery ectasia. Current automated detection systems using
single-paradigm architectures exhibit suboptimal performance in capturing complex …
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Enhancing Early Keratoconus Detection with Multimodal Machine Learning: Integrating Tomography, Biomechanics, and Clinical Risk Factors
K DU, R PENG, Y CHEN, B YUAN, H WU, T CHEN… - American Journal of …, 2025… The dataset included 1,035 eyes from 1,035 participants across five centers: 590
normal controls, 157 eyes with forme fruste keratoconus (FFKC), 143 with subclinical
KC, and 145 with clinical KC. For FFKC detection, the post-feature selection …
K DU, R PENG, Y CHEN, B YUAN, H WU, T CHEN… - American Journal of …, 2025
… The dataset included 1,035 eyes from 1,035 participants across five centers: 590
normal controls, 157 eyes with forme fruste keratoconus (FFKC), 143 with subclinical
KC, and 145 with clinical KC. For FFKC detection, the post-feature selection …
normal controls, 157 eyes with forme fruste keratoconus (FFKC), 143 with subclinical
KC, and 145 with clinical KC. For FFKC detection, the post-feature selection …
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[PDF] Assessing Access to and Utilization of the Advanced Diagnostic and Management Equipment for Early Keratoconus in Public and Private Healthcare Facilities Across …
MM Njeru, SN Maina, I Signes-Soler, HA Golicha - Clinical Optometry, 2025… They generally do not offer eye care services which are predominantly provided
at Levels 4 to 6 including keratoconus care, which consist … keratoconus are
essential for preventing significant visual impairment. Citation9 The ability of ECPs …
MM Njeru, SN Maina, I Signes-Soler, HA Golicha - Clinical Optometry, 2025
… They generally do not offer eye care services which are predominantly provided
at Levels 4 to 6 including keratoconus care, which consist … keratoconus are
essential for preventing significant visual impairment. Citation9 The ability of ECPs …
at Levels 4 to 6 including keratoconus care, which consist … keratoconus are
essential for preventing significant visual impairment. Citation9 The ability of ECPs …
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[HTML] Expression of extracellular matrix protein in advanced keratoconus and the normal human cornea
F Habroosh, P Filippini, A Al Saadi, S Soliman… - Frontiers in Medicine, 2025Background The pre-Descemet layer (Dua's layer) (PDL/DL) and the Descemet
membrane (DM) have the highest expression of elastin in normal corneas. Reduced
expression of elastin occurs in the corneal stroma of patients with keratoconus (KC) …
F Habroosh, P Filippini, A Al Saadi, S Soliman… - Frontiers in Medicine, 2025
Background The pre-Descemet layer (Dua's layer) (PDL/DL) and the Descemet
membrane (DM) have the highest expression of elastin in normal corneas. Reduced
expression of elastin occurs in the corneal stroma of patients with keratoconus (KC) …
membrane (DM) have the highest expression of elastin in normal corneas. Reduced
expression of elastin occurs in the corneal stroma of patients with keratoconus (KC) …
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Comparative analysis of large language models in providing patient information about keratoconus and contact lenses
YK Aribas, AB Tefon Aribas - International Ophthalmology, 2025… Therefore, visual rehabilitation in keratoconus patients is very difficult and has
serious effects on vision-related quality of life [3]. … visual rehabilitation of
keratoconus. Although visual rehabilitation with spectacles may be possible in the …
YK Aribas, AB Tefon Aribas - International Ophthalmology, 2025
… Therefore, visual rehabilitation in keratoconus patients is very difficult and has
serious effects on vision-related quality of life [3]. … visual rehabilitation of
keratoconus. Although visual rehabilitation with spectacles may be possible in the …
serious effects on vision-related quality of life [3]. … visual rehabilitation of
keratoconus. Although visual rehabilitation with spectacles may be possible in the …
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[PDF] Avoiding Surgery: Successful Management of a Patient With Severe Keratoconus Using Scleral Contact Lenses
A Almaweri - Cureus, 2025… This case report demonstrates how a severe keratoconus patient was managed
with scleral … center with a known history of severe keratoconus. His uncorrected
visual acuity was counting … This case study intends to document the success of …
A Almaweri - Cureus, 2025
… This case report demonstrates how a severe keratoconus patient was managed
with scleral … center with a known history of severe keratoconus. His uncorrected
visual acuity was counting … This case study intends to document the success of …
with scleral … center with a known history of severe keratoconus. His uncorrected
visual acuity was counting … This case study intends to document the success of …
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Computational simulation of the interaction between corneal tissue and a novel implantable Nitinol-based device for the treatment of keratoconus
NE Russo - 2025Keratoconus is a progressive, asymmetric condition characterized by corneal
thinning and cone-shaped corneal protrusion, leading to a decline of the visual
acuity. The therapeutic choice depends on the severity of the pathology. In moderate …
NE Russo - 2025
Keratoconus is a progressive, asymmetric condition characterized by corneal
thinning and cone-shaped corneal protrusion, leading to a decline of the visual
acuity. The therapeutic choice depends on the severity of the pathology. In moderate …
thinning and cone-shaped corneal protrusion, leading to a decline of the visual
acuity. The therapeutic choice depends on the severity of the pathology. In moderate …
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[HTML] Quantitative analysis of microvasculature in macular and optic disc regions in keratoconus patients: a systematic review and meta-analysis
L Ling, W Yan, Y Zhao, K Xia, Y Xing, Y Yang, W Wan… - … and Photodynamic Therapy, 2025Background Studies have utilized optical coherence tomography angiography (OCTA)
to assess vessel density in the macular and optic disc regions among patients with
keratoconus (KC); however, the findings have been incongruent. This study aimed to …
L Ling, W Yan, Y Zhao, K Xia, Y Xing, Y Yang, W Wan… - … and Photodynamic Therapy, 2025
Background Studies have utilized optical coherence tomography angiography (OCTA)
to assess vessel density in the macular and optic disc regions among patients with
keratoconus (KC); however, the findings have been incongruent. This study aimed to …
to assess vessel density in the macular and optic disc regions among patients with
keratoconus (KC); however, the findings have been incongruent. This study aimed to …
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Comparative Effectiveness of Corneal and Scleral Contact Lenses in Visual Rehabilitation of Keratoconus Patients in Sana'a: A Cross-Sectional Study
AFS Al-Jaradi, MS Al-Awar, A Alarabi, K Alkhateeb… - Al-Razi University Journal …, 2025Background: Keratoconus (KC) is a progressive non-inflammatory eye disorder
characterized by corneal thinning and ectasia, leading to conical protrusion,
irregular astigmatism, myopia, and subsequent vision impairment. Objective: This …
AFS Al-Jaradi, MS Al-Awar, A Alarabi, K Alkhateeb… - Al-Razi University Journal …, 2025
Background: Keratoconus (KC) is a progressive non-inflammatory eye disorder
characterized by corneal thinning and ectasia, leading to conical protrusion,
irregular astigmatism, myopia, and subsequent vision impairment. Objective: This …
characterized by corneal thinning and ectasia, leading to conical protrusion,
irregular astigmatism, myopia, and subsequent vision impairment. Objective: This …
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[PDF] Long-term results of intrastromal ring implantation for keratoconus
HCD de Rezende Rocha, BK Moscovici, DD da Gama… - Rev Bras Oftalmol, 2025… (5-10) Evaluating the keratoconus types, K1 and K2 improved only in astigmatic
and oval keratoconus. We only had improvement in topographic AST in oval
keratoconus. Sandes et al. studied 140 arc rings in PMD patients with good results …
HCD de Rezende Rocha, BK Moscovici, DD da Gama… - Rev Bras Oftalmol, 2025
… (5-10) Evaluating the keratoconus types, K1 and K2 improved only in astigmatic
and oval keratoconus. We only had improvement in topographic AST in oval
keratoconus. Sandes et al. studied 140 arc rings in PMD patients with good results …
and oval keratoconus. We only had improvement in topographic AST in oval
keratoconus. Sandes et al. studied 140 arc rings in PMD patients with good results …
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Corneal Biomechanical Alterations in Eyes After Radial Keratotomy Compared With Keratoconus.
Y Iwamoto, S Koh, R Inoue, R Ambrósio Jr, N Maeda… - Journal of Refractive …, 2025… Keratoconus. We enrolled 20 eyes from 20 patients with keratoconus, age-matched
to those in the post-RK group. Keratoconus diagnosis was based on the presence of
at least one slit-lamp finding, including corneal stromal thinning, corneal protrusion …
Y Iwamoto, S Koh, R Inoue, R Ambrósio Jr, N Maeda… - Journal of Refractive …, 2025
… Keratoconus. We enrolled 20 eyes from 20 patients with keratoconus, age-matched
to those in the post-RK group. Keratoconus diagnosis was based on the presence of
at least one slit-lamp finding, including corneal stromal thinning, corneal protrusion …
to those in the post-RK group. Keratoconus diagnosis was based on the presence of
at least one slit-lamp finding, including corneal stromal thinning, corneal protrusion …
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Repeatability of a Dual-Scheimpflug Placido Disc Corneal Tomographer/Topographer in Eyes with Keratoconus
A Poulsen, DH Jang, M Khan, ZN Al-Mohtaseb… - Clinical Ophthalmology, 2025… Keratoconus is the most common corneal degeneration, with an estimated
prevalence … Achieving a consensus in the definition of progression in keratoconus
is limited by the … Another study by Martinez-Abad followed patients with …
A Poulsen, DH Jang, M Khan, ZN Al-Mohtaseb… - Clinical Ophthalmology, 2025
… Keratoconus is the most common corneal degeneration, with an estimated
prevalence … Achieving a consensus in the definition of progression in keratoconus
is limited by the … Another study by Martinez-Abad followed patients with …
prevalence … Achieving a consensus in the definition of progression in keratoconus
is limited by the … Another study by Martinez-Abad followed patients with …
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Efficacy and Safety of 7.2 J/cm² Accelerated Corneal Cross-Linking in Pediatric and Adult Keratoconus: A Comparative Study
M Turunç, A Özdemir, E Can - Korean journal of ophthalmology: KJO… Purpose: To evaluate and compare the short-term outcomes of an accelerated
corneal crosslinking (CXL) protocol with a total energy dose of 7.2 J/cm² in pediatric
and adult keratoconus patients. Methods: This study included 113 eyes of 82 …
M Turunç, A Özdemir, E Can - Korean journal of ophthalmology: KJO
… Purpose: To evaluate and compare the short-term outcomes of an accelerated
corneal crosslinking (CXL) protocol with a total energy dose of 7.2 J/cm² in pediatric
and adult keratoconus patients. Methods: This study included 113 eyes of 82 …
corneal crosslinking (CXL) protocol with a total energy dose of 7.2 J/cm² in pediatric
and adult keratoconus patients. Methods: This study included 113 eyes of 82 …
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[HTML] Genetic Epidemiological Analysis of the Keratoconus Genetic Model in the Chinese Keratoconus Cohort Study
S Yin, L Xu, K Yang, Q Fan, Y Gu, C Yin, Y Zang… - … Ophthalmology & Visual …, 2025Purpose: Keratoconus (KC) is a corneal disorder characterized by progressive
corneal protrusion and thinning. Our previous studies have demonstrated that
genetic factors influence KC occurrence. The purpose of this study was to explore …
S Yin, L Xu, K Yang, Q Fan, Y Gu, C Yin, Y Zang… - … Ophthalmology & Visual …, 2025
Purpose: Keratoconus (KC) is a corneal disorder characterized by progressive
corneal protrusion and thinning. Our previous studies have demonstrated that
genetic factors influence KC occurrence. The purpose of this study was to explore …
corneal protrusion and thinning. Our previous studies have demonstrated that
genetic factors influence KC occurrence. The purpose of this study was to explore …
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Outcomes of cataract surgery in patients with previous corneal transplantation for keratoconus: comparison of PK and DALK
K Bayat, MA Javadi, S Feizi, G Izadi-Jorshari, P Pooyan - International Ophthalmology, 2025Purpose To evaluate the visual and refractive outcomes of cataract surgery in
patients with previous deep anterior lamellar keratoplasty (DALK) or penetrating
keratoplasty (PK) performed for keratoconus. Methods This cross-sectional study …
K Bayat, MA Javadi, S Feizi, G Izadi-Jorshari, P Pooyan - International Ophthalmology, 2025
Purpose To evaluate the visual and refractive outcomes of cataract surgery in
patients with previous deep anterior lamellar keratoplasty (DALK) or penetrating
keratoplasty (PK) performed for keratoconus. Methods This cross-sectional study …
patients with previous deep anterior lamellar keratoplasty (DALK) or penetrating
keratoplasty (PK) performed for keratoconus. Methods This cross-sectional study …
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Automated Detection of Keratoconus using EfficientNetB7: A Deep Learning Approach
SVK Yadav, A Kaur - 2025 International Conference on Electronics, AI and …, 2025… , allowing the model to depict the complex patterns linked to keratoconus. The
proposed methodology has achieved a validation accuracy … early detection of
keratoconus by incorporating corneal maps that can improve the quality of life of …
SVK Yadav, A Kaur - 2025 International Conference on Electronics, AI and …, 2025
… , allowing the model to depict the complex patterns linked to keratoconus. The
proposed methodology has achieved a validation accuracy … early detection of
keratoconus by incorporating corneal maps that can improve the quality of life of …
proposed methodology has achieved a validation accuracy … early detection of
keratoconus by incorporating corneal maps that can improve the quality of life of …
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CMVFT: A Multi-Scale Attention Guided Framework for Enhanced Keratoconus Suspect Classification in Multi-View Corneal Topography
Y Lu, B Li, Y Zhang, Y Qi, X Shi - American Journal of Ophthalmology, 2025… By compensating for the representation gap inherent in small-sample settings,
CMVFT shows promise in enabling the identification of suspect keratoconus cases
and supporting early intervention strategies, with prospective implications for early …
Y Lu, B Li, Y Zhang, Y Qi, X Shi - American Journal of Ophthalmology, 2025
… By compensating for the representation gap inherent in small-sample settings,
CMVFT shows promise in enabling the identification of suspect keratoconus cases
and supporting early intervention strategies, with prospective implications for early …
CMVFT shows promise in enabling the identification of suspect keratoconus cases
and supporting early intervention strategies, with prospective implications for early …
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A Novel Optical Coherence Tomography–based Keratoconus Diagnostic Index Incorporating Stromal and Epithelial Features
NJ Lu, C Koppen, S Ní Dhubhghaill, QM Wang… - Journal of Refractive …, 2025… This study developed a novel OCT-based keratoconus diagnostic index
encompassing whole corneal and stromal and upper-layer epithelial information to
assist in the clinical diagnosis of keratoconus. Following the development of this …
NJ Lu, C Koppen, S Ní Dhubhghaill, QM Wang… - Journal of Refractive …, 2025
… This study developed a novel OCT-based keratoconus diagnostic index
encompassing whole corneal and stromal and upper-layer epithelial information to
assist in the clinical diagnosis of keratoconus. Following the development of this …
encompassing whole corneal and stromal and upper-layer epithelial information to
assist in the clinical diagnosis of keratoconus. Following the development of this …
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CURRENT OPINION The immunopathology of keratoconus: tear film biomarkers and immune pathways
M Lombardoa, M Fruschellic, S Serraoa - Curr Opin Allergy Clin Immunol, 2025… This review explores established risk factors for keratoconus and current insights
into tear film immune biomarkers, with a focus on the role … Today, keratoconus is
considered as a multifactorial disease with both genetic and environmental …
M Lombardoa, M Fruschellic, S Serraoa - Curr Opin Allergy Clin Immunol, 2025
… This review explores established risk factors for keratoconus and current insights
into tear film immune biomarkers, with a focus on the role … Today, keratoconus is
considered as a multifactorial disease with both genetic and environmental …
into tear film immune biomarkers, with a focus on the role … Today, keratoconus is
considered as a multifactorial disease with both genetic and environmental …
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[PDF] Corneal Endothelial Morphology in Keratoconus: A Specular Microscopy Study
F Nasir, M Sharma, F Nasir… with keratoconus. Results: A statistically significant decline in endothelial cell
density (ECD) was observed with advancing keratoconus stages: … Conclusion:
The progressive decline in ECD with increasing keratoconus severity highlights the …
F Nasir, M Sharma, F Nasir
… with keratoconus. Results: A statistically significant decline in endothelial cell
density (ECD) was observed with advancing keratoconus stages: … Conclusion:
The progressive decline in ECD with increasing keratoconus severity highlights the …
density (ECD) was observed with advancing keratoconus stages: … Conclusion:
The progressive decline in ECD with increasing keratoconus severity highlights the …
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Comment on: Evaluating the Global Consensus on Keratoconus and Ectatic Diseases: Agreements Reached on Subclinical Keratoconus
Y Diao - American Journal of Ophthalmology… keratocytes and alterations in collagen arrangement even in mild keratoconus.
Given the lower density of posterior stromal keratocytes … as a diagnostic criterion
for keratoconus. This approach could potentially aid in distinguishing keratoconus …
Y Diao - American Journal of Ophthalmology
… keratocytes and alterations in collagen arrangement even in mild keratoconus.
Given the lower density of posterior stromal keratocytes … as a diagnostic criterion
for keratoconus. This approach could potentially aid in distinguishing keratoconus …
Given the lower density of posterior stromal keratocytes … as a diagnostic criterion
for keratoconus. This approach could potentially aid in distinguishing keratoconus …
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[PDF] Unilateral PPMD with keratoconus: An atypical presentation. Sci Set J of Ophthalmology & Eye Care, 4 (3). 01-04
A Soman - 2025… keratoconus and secondary glaucoma [2-6]. We report a case of a patient with
changes consistent with unilateral PPMD with advanced keratoconus in the … We
report a case of unilateral posterior polymorphous corneal dystrophy with advanced …
A Soman - 2025
… keratoconus and secondary glaucoma [2-6]. We report a case of a patient with
changes consistent with unilateral PPMD with advanced keratoconus in the … We
report a case of unilateral posterior polymorphous corneal dystrophy with advanced …
changes consistent with unilateral PPMD with advanced keratoconus in the … We
report a case of unilateral posterior polymorphous corneal dystrophy with advanced …
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[PDF] Refractive Lenticule-Assisted Accelerated Corneal Cross-linking: A Three-Year Clinical Observation in Patients with Thin Keratoconus
Y Li, M Wang, L Guo, D Zhao, C Zhou - 2025… Methods: This study retrospectively included 63 eyes (42 cases) with progressive
keratoconus who underwent A-CXL in our hospital from … CXL for thin keratoconus
demonstrates comparable efficacy and safety to conventional A-CXL in the …
Y Li, M Wang, L Guo, D Zhao, C Zhou - 2025
… Methods: This study retrospectively included 63 eyes (42 cases) with progressive
keratoconus who underwent A-CXL in our hospital from … CXL for thin keratoconus
demonstrates comparable efficacy and safety to conventional A-CXL in the …
keratoconus who underwent A-CXL in our hospital from … CXL for thin keratoconus
demonstrates comparable efficacy and safety to conventional A-CXL in the …
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Evaluation of keratoconus and its impact on vision-related quality of life
T Park, E Rueff, AL Nguyen - Optometry and vision science: official publication of the …Significance This study adds to the understanding of how different factors affect
quality of life in people with keratoconus. Purpose To evaluate how various
demographic factors, clinical characteristics, and treatment modalities influence …
T Park, E Rueff, AL Nguyen - Optometry and vision science: official publication of the …
Significance This study adds to the understanding of how different factors affect
quality of life in people with keratoconus. Purpose To evaluate how various
demographic factors, clinical characteristics, and treatment modalities influence …
quality of life in people with keratoconus. Purpose To evaluate how various
demographic factors, clinical characteristics, and treatment modalities influence …
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Is keratoconus limited to the cornea? A prospective analysis of corneal biomechanics using corneal visualisation Scheimpflug technology
S Ermis, E Ozal, IC Arabaci, O Tastan, FO Aydın… - … optics: the journal of the British …Purpose This study aimed to evaluate whether corneal biomechanical alterations in
keratoconus (KC) are associated with changes in the lamina cribrosa (LC), retinal
nerve fibre layer (RNFL) and peripapillary microvascular structures by comparing …
S Ermis, E Ozal, IC Arabaci, O Tastan, FO Aydın… - … optics: the journal of the British …
Purpose This study aimed to evaluate whether corneal biomechanical alterations in
keratoconus (KC) are associated with changes in the lamina cribrosa (LC), retinal
nerve fibre layer (RNFL) and peripapillary microvascular structures by comparing …
keratoconus (KC) are associated with changes in the lamina cribrosa (LC), retinal
nerve fibre layer (RNFL) and peripapillary microvascular structures by comparing …
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[HTML] Progression and regression of keratoconus in an Iranian population
A Jamali, H Hashemi, P Nabovati, M Khabazkhoob - Scientific Reports, 2025To evaluate temporal changes in keratoconus (KCN) in individuals of different ages.
In this historical cohort study, participants diagnosed with KCN underwent two
evaluations at separate time points. Each evaluation included corneal imaging using …
A Jamali, H Hashemi, P Nabovati, M Khabazkhoob - Scientific Reports, 2025
To evaluate temporal changes in keratoconus (KCN) in individuals of different ages.
In this historical cohort study, participants diagnosed with KCN underwent two
evaluations at separate time points. Each evaluation included corneal imaging using …
In this historical cohort study, participants diagnosed with KCN underwent two
evaluations at separate time points. Each evaluation included corneal imaging using …
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[HTML] Corneal epithelial aberrations: a novel diagnostic tool for keratoconus and forme fruste keratoconus
R Ning, CS Lei, X Yang, Y Li, Y Yang, I Gustafsson… - Eye and Vision, 2025… To assess the ability of corneal epithelial aberrations to discriminate forme fruste
keratoconus (FFKC) and keratoconus (KC) from normal … Diagnostic value of
corneal epithelial and stromal thickness distribution profiles in forme fruste …
R Ning, CS Lei, X Yang, Y Li, Y Yang, I Gustafsson… - Eye and Vision, 2025
… To assess the ability of corneal epithelial aberrations to discriminate forme fruste
keratoconus (FFKC) and keratoconus (KC) from normal … Diagnostic value of
corneal epithelial and stromal thickness distribution profiles in forme fruste …
keratoconus (FFKC) and keratoconus (KC) from normal … Diagnostic value of
corneal epithelial and stromal thickness distribution profiles in forme fruste …
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Paying attention to the timing and methods of minimally invasive surgery for the treatment of keratoconus
H Gao, LL Wang, WY Shi - [Zhonghua yan ke za zhi] Chinese journal of …, 2025Keratoconus is the … As keratoconus progresses, the optimal timing and selection
of surgical methods warrant focused attention and discussion. This article proposes
three guiding principles on the selection of minimally invasive surgical approaches …
H Gao, LL Wang, WY Shi - [Zhonghua yan ke za zhi] Chinese journal of …, 2025
Keratoconus is the … As keratoconus progresses, the optimal timing and selection
of surgical methods warrant focused attention and discussion. This article proposes
three guiding principles on the selection of minimally invasive surgical approaches …
of surgical methods warrant focused attention and discussion. This article proposes
three guiding principles on the selection of minimally invasive surgical approaches …
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Association between corneal densitometry at initial presentation and future progression across age groups in keratoconus
E Atalay, F Özdemir, MD Bilgeç, O Özalp - Ophthalmic & physiological optics: the journal of …Purpose This study investigated corneal densitometry values at presentation,
acquired via Scheimpflug imaging, in eyes with and without documented progression.
The aim was to determine whether corneal densitometry values at presentation were …
E Atalay, F Özdemir, MD Bilgeç, O Özalp - Ophthalmic & physiological optics: the journal of …
Purpose This study investigated corneal densitometry values at presentation,
acquired via Scheimpflug imaging, in eyes with and without documented progression.
The aim was to determine whether corneal densitometry values at presentation were …
acquired via Scheimpflug imaging, in eyes with and without documented progression.
The aim was to determine whether corneal densitometry values at presentation were …
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The role of transforming growth factor beta-1 (TGF-β 1) in the development of fibrosis in keratoconus
M Yildirim - Irish Journal of Medical Science (1971-), 2025… The etiology of keratoconus, a disease characterized by deterioration in the
extracellular … Factor Beta-1) and keratoconus because of its essential role in
extracellular matrix secretion. … This study aimed to assess serum TGF-β1 levels in …
M Yildirim - Irish Journal of Medical Science (1971-), 2025
… The etiology of keratoconus, a disease characterized by deterioration in the
extracellular … Factor Beta-1) and keratoconus because of its essential role in
extracellular matrix secretion. … This study aimed to assess serum TGF-β1 levels in …
extracellular … Factor Beta-1) and keratoconus because of its essential role in
extracellular matrix secretion. … This study aimed to assess serum TGF-β1 levels in …
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[HTML] Capacity of health facilities to diagnose and manage keratoconus: a Kilimanjaro region case study
FP Maro, VR Moodley - International Ophthalmology, 2025Introduction Keratoconus (KC), is a corneal disease that causes visual impairment,
which diminishes thequality of life (QoL) of affected individuals. Although most eye
care practitioners in Tanzania anecdotally report a significant number of patients …
FP Maro, VR Moodley - International Ophthalmology, 2025
Introduction Keratoconus (KC), is a corneal disease that causes visual impairment,
which diminishes thequality of life (QoL) of affected individuals. Although most eye
care practitioners in Tanzania anecdotally report a significant number of patients …
which diminishes thequality of life (QoL) of affected individuals. Although most eye
care practitioners in Tanzania anecdotally report a significant number of patients …
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[HTML] Efficacy of Rose-K lens in enhancing visual acuity and contrast sensitivity in keratoconus
H ALkhalasi, ZD Mohamed - Medical hypothesis, discovery & innovation in …, 2025… ) and CS in patients with keratoconus. Methods: In this prospective study, we
recruited adults with varying keratoconus severities from the Armed … Keratoconus
severity was graded using the Amsler–Krumeich classification system. All …
H ALkhalasi, ZD Mohamed - Medical hypothesis, discovery & innovation in …, 2025
… ) and CS in patients with keratoconus. Methods: In this prospective study, we
recruited adults with varying keratoconus severities from the Armed … Keratoconus
severity was graded using the Amsler–Krumeich classification system. All …
recruited adults with varying keratoconus severities from the Armed … Keratoconus
severity was graded using the Amsler–Krumeich classification system. All …
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Surgical Options for Keratoconus Patients Clinical Guideline
S Saadeddin - 2025Purpose of the Study This study aims to develop a safe and effective clinical
guideline for the surgical management of keratoconus, facilitating the selection of
appropriate treatment modalities based on corneal classification, disease severity …
S Saadeddin - 2025
Purpose of the Study This study aims to develop a safe and effective clinical
guideline for the surgical management of keratoconus, facilitating the selection of
appropriate treatment modalities based on corneal classification, disease severity …
guideline for the surgical management of keratoconus, facilitating the selection of
appropriate treatment modalities based on corneal classification, disease severity …
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Demographic Characteristics of Keratoconus in a Sample of Iraqi Patients
DJK Alzubaidy, ZA Abdulhussain, OS Hussein - European Journal of Medical and …, 2025Keratoconus (KC) is a progressive, bilateral corneal ectasia that typically emerges in
adolescence or early adulthood. It leads to thinning and protrusion of the cornea,
resulting in visual impairment. Understanding the demographic and clinical …
DJK Alzubaidy, ZA Abdulhussain, OS Hussein - European Journal of Medical and …, 2025
Keratoconus (KC) is a progressive, bilateral corneal ectasia that typically emerges in
adolescence or early adulthood. It leads to thinning and protrusion of the cornea,
resulting in visual impairment. Understanding the demographic and clinical …
adolescence or early adulthood. It leads to thinning and protrusion of the cornea,
resulting in visual impairment. Understanding the demographic and clinical …
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The immunopathology of keratoconus: tear film biomarkers and immune pathways
M Lombardo, M Fruschelli, S Serrao - Current opinion in allergy and clinical immunology… Purpose of review: This review explores established risk factors for keratoconus
and current … a key driver in the onset and progression of keratoconus. Genetics
establish a foundation for a … immune markers that shed light on keratoconus …
M Lombardo, M Fruschelli, S Serrao - Current opinion in allergy and clinical immunology
… Purpose of review: This review explores established risk factors for keratoconus
and current … a key driver in the onset and progression of keratoconus. Genetics
establish a foundation for a … immune markers that shed light on keratoconus …
and current … a key driver in the onset and progression of keratoconus. Genetics
establish a foundation for a … immune markers that shed light on keratoconus …
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Unraveling the immune axis of ocular surface microbiota in keratoconus
R Shawer, A Solomon - Current Opinion in Allergy and Clinical Immunology… For instance, Actinobacteria, the predominant phylum in healthy individuals, was
found to be lowered across keratoconus grades and to decline in keratoconus patients in
proportion to the severity of their condition. In contrast to controls, however …
R Shawer, A Solomon - Current Opinion in Allergy and Clinical Immunology
… For instance, Actinobacteria, the predominant phylum in healthy individuals, was
found to be lowered across keratoconus grades and to decline in keratoconus patients in
proportion to the severity of their condition. In contrast to controls, however …
found to be lowered across keratoconus grades and to decline in keratoconus patients in
proportion to the severity of their condition. In contrast to controls, however …
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[PDF] Reverse donut sign in advanced keratoconus
R Natarajan, S Rafeek, JJ Balaji - Indian Journal of Ophthalmology-Case Reports, 2025Discussion The corneal epithelium compensates for anterior stromal irregularities.[1]
In early keratoconus, epithelial thinning over the cone occurs as a natural
mechanism to neutralize the steep cornea with an annulus of epithelial thickening (donut …
R Natarajan, S Rafeek, JJ Balaji - Indian Journal of Ophthalmology-Case Reports, 2025
Discussion The corneal epithelium compensates for anterior stromal irregularities.[1]
In early keratoconus, epithelial thinning over the cone occurs as a natural
mechanism to neutralize the steep cornea with an annulus of epithelial thickening (donut …
In early keratoconus, epithelial thinning over the cone occurs as a natural
mechanism to neutralize the steep cornea with an annulus of epithelial thickening (donut …
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Keratoconus Following Cataract Extraction: A Patient-Centered Perspective
Z Firdhaus, GY Keat, K Haireen, CH Jemaima - Cureus, 2025… Here, we report a case of a patient with severe keratoconus who underwent
cataract surgery in both eyes, leading to a remarkable … in cataract surgery for
stable keratoconus patients. This case highlights that significant astigmatism …
Z Firdhaus, GY Keat, K Haireen, CH Jemaima - Cureus, 2025
… Here, we report a case of a patient with severe keratoconus who underwent
cataract surgery in both eyes, leading to a remarkable … in cataract surgery for
stable keratoconus patients. This case highlights that significant astigmatism …
cataract surgery in both eyes, leading to a remarkable … in cataract surgery for
stable keratoconus patients. This case highlights that significant astigmatism …
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[PDF] Corneal Remodeling Using Laser Asymmetric Keratectomy in Patients with Keratoconus Suspect
BM Min, HJ Cheon - 2025Background: To assess laser epithelial keratomileusis (LASEK) linked laser
asymmetric keratectomy (L-LAK) treatment outcome for keratoconus suspect (KCS)
by evaluating corneal regularity in order to avoid the postoperative corneal ectasia …
BM Min, HJ Cheon - 2025
Background: To assess laser epithelial keratomileusis (LASEK) linked laser
asymmetric keratectomy (L-LAK) treatment outcome for keratoconus suspect (KCS)
by evaluating corneal regularity in order to avoid the postoperative corneal ectasia …
asymmetric keratectomy (L-LAK) treatment outcome for keratoconus suspect (KCS)
by evaluating corneal regularity in order to avoid the postoperative corneal ectasia …
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[PDF] Implantation of an additional intraocular lens for keratoconus in a pseudophakic eye
AD Chuprov, VL Kim, IA Stolyar - Journal of Clinical Practice, 2025BACKGROUND: In the accessible literature sources, there is insufficient information
on the correction of refraction abnormalities in cases of keratoconus, due to which
exploring the modern approaches in the implantation of additional intraocular lenses …
AD Chuprov, VL Kim, IA Stolyar - Journal of Clinical Practice, 2025
BACKGROUND: In the accessible literature sources, there is insufficient information
on the correction of refraction abnormalities in cases of keratoconus, due to which
exploring the modern approaches in the implantation of additional intraocular lenses …
on the correction of refraction abnormalities in cases of keratoconus, due to which
exploring the modern approaches in the implantation of additional intraocular lenses …
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[PDF] Keratoconus in Eastern Mediterranean Region: Prevalence and risk factors
ZD Mohamed - African Vision and Eye Health, 2025… Keratoconus (KC) is a degenerative disorder characterised by alterations in
corneal morphology … Keratoconus has potential links to several risk factors,
including prolonged eye rubbing, … Keratoconus occurrence rates show significant …
ZD Mohamed - African Vision and Eye Health, 2025
… Keratoconus (KC) is a degenerative disorder characterised by alterations in
corneal morphology … Keratoconus has potential links to several risk factors,
including prolonged eye rubbing, … Keratoconus occurrence rates show significant …
corneal morphology … Keratoconus has potential links to several risk factors,
including prolonged eye rubbing, … Keratoconus occurrence rates show significant …
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[PDF] Transfer Learning-Based Keratoconus Detection from Scheimpflug Images
JC Moreno, BM Corcoy, AC Vaquero - Jornada de Jóvenes Investigadores del I3A, 2025Preclinical detection of keratoconus is crucial to avoid irreversible corneal damage
associated to refractive surgery for laser myopia correction. This work proposes, for
the first time, a deep learning-based approach for preclinical keratoconus diagnosis …
JC Moreno, BM Corcoy, AC Vaquero - Jornada de Jóvenes Investigadores del I3A, 2025
Preclinical detection of keratoconus is crucial to avoid irreversible corneal damage
associated to refractive surgery for laser myopia correction. This work proposes, for
the first time, a deep learning-based approach for preclinical keratoconus diagnosis …
associated to refractive surgery for laser myopia correction. This work proposes, for
the first time, a deep learning-based approach for preclinical keratoconus diagnosis …
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An optimized multi-scale dilated attention layer for keratoconus disease classification
K Balaji, N Gobalakrishnan - International Ophthalmology, 2025Materials and Methods The proposed model, Optimized MSDALNet, integrates a
Multi-Scale Dilated Attention Layer (MSDAL) to capture local and global corneal
features at varying spatial resolutions. Training is optimized using Arctic Puffin …
K Balaji, N Gobalakrishnan - International Ophthalmology, 2025
Materials and Methods The proposed model, Optimized MSDALNet, integrates a
Multi-Scale Dilated Attention Layer (MSDAL) to capture local and global corneal
features at varying spatial resolutions. Training is optimized using Arctic Puffin …
Multi-Scale Dilated Attention Layer (MSDAL) to capture local and global corneal
features at varying spatial resolutions. Training is optimized using Arctic Puffin …
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Peripheral Corneal Perforation After Acute Hydrops in Keratoconus
H Fukuoka, C Sotozono - Ophthalmology, 2025A 51-year-old man with keratoconus and atopic dermatitis presented with acute
vision loss to counting fingers. Slit-lamp examination revealed central stromal
edema characteristic of acute hydrops (A). Fluorescein staining demonstrated …
H Fukuoka, C Sotozono - Ophthalmology, 2025
A 51-year-old man with keratoconus and atopic dermatitis presented with acute
vision loss to counting fingers. Slit-lamp examination revealed central stromal
edema characteristic of acute hydrops (A). Fluorescein staining demonstrated …
vision loss to counting fingers. Slit-lamp examination revealed central stromal
edema characteristic of acute hydrops (A). Fluorescein staining demonstrated …
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[HTML] From CLMI. X to CLMIX-AI: A Machine Learning-Based Upgrade of the Cone Location and Magnitude Index Expanded to Detect Keratoconus Suspects
B Hammoud, Z Wehbi, JF Assaf, CJ Roberts… - Ophthalmology Science, 2025… Major criteria included keratoconus prediction index (KPI) exceeding 30%, an
inferior-superior value of more than 2.38 diopters (D), and … of patients with highly
asymmetric keratoconus. While these corneas did not meet the pre-established …
B Hammoud, Z Wehbi, JF Assaf, CJ Roberts… - Ophthalmology Science, 2025
… Major criteria included keratoconus prediction index (KPI) exceeding 30%, an
inferior-superior value of more than 2.38 diopters (D), and … of patients with highly
asymmetric keratoconus. While these corneas did not meet the pre-established …
inferior-superior value of more than 2.38 diopters (D), and … of patients with highly
asymmetric keratoconus. While these corneas did not meet the pre-established …
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Artificial Intelligence in the Treatment of Keratoconus: The Use of Intracorneal Ring Segments
C Fariselli, F Versace, JL Alio - Artificial Intelligence in Ophthalmology, 2025The chapter analyzes the clinical results of an artificial neural network (ANN) that
has been processed in order to improve the predictability of intracorneal ring
segments (ICRS) implantation in keratoconus. The ANN to guide ICRS provides an …
C Fariselli, F Versace, JL Alio - Artificial Intelligence in Ophthalmology, 2025
The chapter analyzes the clinical results of an artificial neural network (ANN) that
has been processed in order to improve the predictability of intracorneal ring
segments (ICRS) implantation in keratoconus. The ANN to guide ICRS provides an …
has been processed in order to improve the predictability of intracorneal ring
segments (ICRS) implantation in keratoconus. The ANN to guide ICRS provides an …
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Biomedical image-based keratoconus classification using convolutional transformers and grey goose optimization
K Balaji, N Gobalakrishnan - Biomedical Signal Processing and Control, 2026Background Keratoconus (KCN) is a progressive corneal disorder that leads to
visual distortion and increases the risk of complications during refractive surgical
procedures. Accurate and early diagnosis is critical for effective clinical management …
K Balaji, N Gobalakrishnan - Biomedical Signal Processing and Control, 2026
Background Keratoconus (KCN) is a progressive corneal disorder that leads to
visual distortion and increases the risk of complications during refractive surgical
procedures. Accurate and early diagnosis is critical for effective clinical management …
visual distortion and increases the risk of complications during refractive surgical
procedures. Accurate and early diagnosis is critical for effective clinical management …
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[HTML] A Hierarchical Deep Learning Approach for Early Keratoconus Detection
A Rahdar, WM Munir, K Bayat, F Karimian… - … Ophthalmology & Visual …, 2025A Hierarchical Deep Learning Approach for Early Keratoconus Detection | IOVS |
ARVO Journals … Purpose : To identify forme fruste keratoconus (FFKCN) and
distinguish it from normal eyes and eyes with established keratoconus (KCN). …
A Rahdar, WM Munir, K Bayat, F Karimian… - … Ophthalmology & Visual …, 2025
A Hierarchical Deep Learning Approach for Early Keratoconus Detection | IOVS |
ARVO Journals … Purpose : To identify forme fruste keratoconus (FFKCN) and
distinguish it from normal eyes and eyes with established keratoconus (KCN). …
ARVO Journals … Purpose : To identify forme fruste keratoconus (FFKCN) and
distinguish it from normal eyes and eyes with established keratoconus (KCN). …
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Concatenation of optical coherence tomography maps for keratoconus detection with deep learning classifiers
RM Hazarbassanov, L Weinketz, LA Dos Santos… - … Ophthalmology & Visual …, 2025… keratoconus"(36), or "keratoconus"(31) using the ANTERION instrument (Heidelberg
engineering Ltd). Eight of twelve maps per eye were selected for keratoconus
diagnosis… Data for suspected keratoconus and keratoconus were augmented to …
RM Hazarbassanov, L Weinketz, LA Dos Santos… - … Ophthalmology & Visual …, 2025
… keratoconus"(36), or "keratoconus"(31) using the ANTERION instrument (Heidelberg
engineering Ltd). Eight of twelve maps per eye were selected for keratoconus
diagnosis… Data for suspected keratoconus and keratoconus were augmented to …
engineering Ltd). Eight of twelve maps per eye were selected for keratoconus
diagnosis… Data for suspected keratoconus and keratoconus were augmented to …
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Use of the Corneal Light Eye Assessment (CLEA) Device to Perform Population-Based Keratoconus Screening in High-Risk Populations
A Godfrey, N White, M Indaram - Investigative Ophthalmology & Visual Science, 2025Purpose: While trisomy 21 has been established as a risk factor for keratoconus (KC),
the association between KC and other high-risk populations such as patients with
neurodevelopmental disorders (NDD) and atopic diseases remains understudied …
A Godfrey, N White, M Indaram - Investigative Ophthalmology & Visual Science, 2025
Purpose: While trisomy 21 has been established as a risk factor for keratoconus (KC),
the association between KC and other high-risk populations such as patients with
neurodevelopmental disorders (NDD) and atopic diseases remains understudied …
the association between KC and other high-risk populations such as patients with
neurodevelopmental disorders (NDD) and atopic diseases remains understudied …
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[HTML] Construction and Characteristics of an Adjustable Biomechanical In Vitro Corneal Stromal Model Simulating Keratoconus Pathological Features
X Li, K Li, J Gu, X Sun, Y Liang, C Ding, Y Chen… - Materials Today Bio, 2025Keratoconus (KC) is a prevalent ectatic corneal disease influenced by corneal
biomechanics, though its pathogenesis remains unclear. Constructing an in vitro
corneal model with adjustable biomechanics is essential for studying keratoconus …
X Li, K Li, J Gu, X Sun, Y Liang, C Ding, Y Chen… - Materials Today Bio, 2025
Keratoconus (KC) is a prevalent ectatic corneal disease influenced by corneal
biomechanics, though its pathogenesis remains unclear. Constructing an in vitro
corneal model with adjustable biomechanics is essential for studying keratoconus …
biomechanics, though its pathogenesis remains unclear. Constructing an in vitro
corneal model with adjustable biomechanics is essential for studying keratoconus …
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Barriers to entry for keratoconus patients to corneal cross-linking services in provincial New Zealand: a patient and family qualitative research project
C Parsloe, M Naude, J Read - The New Zealand medical journal, 2025… This study aimed to identify barriers to early diagnosis and treatment of
keratoconus among … whānau and patients with serious or progressive
keratoconus who underwent corneal cross-linking at … Finally, we discussed …
C Parsloe, M Naude, J Read - The New Zealand medical journal, 2025
… This study aimed to identify barriers to early diagnosis and treatment of
keratoconus among … whānau and patients with serious or progressive
keratoconus who underwent corneal cross-linking at … Finally, we discussed …
keratoconus among … whānau and patients with serious or progressive
keratoconus who underwent corneal cross-linking at … Finally, we discussed …
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[PDF] Validity of keratoconus screening tests
ZA Rashid, KP Mashige, VR Moodley - Clinical and Experimental Optometry, 2025… was available in the non-keratoconus, keratoconus suspect and keratoconus
groups respectively. For the analysis of the difference in Kmax in the non-keratoconus
group; the 5576 eyes included 5528 eyes of the 2764 students classified as non-keratoconus …
ZA Rashid, KP Mashige, VR Moodley - Clinical and Experimental Optometry, 2025
… was available in the non-keratoconus, keratoconus suspect and keratoconus
groups respectively. For the analysis of the difference in Kmax in the non-keratoconus
group; the 5576 eyes included 5528 eyes of the 2764 students classified as non-keratoconus …
groups respectively. For the analysis of the difference in Kmax in the non-keratoconus
group; the 5576 eyes included 5528 eyes of the 2764 students classified as non-keratoconus …
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Exploring the oxidative stress-related molecular clusters in the cornea of patients with keratoconus
C Gu, L Wang, Q Jiang, Z Gu, X Li, Y Yao, Q Wang… - Experimental Eye Research, 2025Keratoconus (KC), a progressive corneal disorder, severely compromises vision and
quality of life, underscoring the urgency for biomarker identification and therapeutic
advancements. This study investigates oxidative stress-related molecular clusters in …
C Gu, L Wang, Q Jiang, Z Gu, X Li, Y Yao, Q Wang… - Experimental Eye Research, 2025
Keratoconus (KC), a progressive corneal disorder, severely compromises vision and
quality of life, underscoring the urgency for biomarker identification and therapeutic
advancements. This study investigates oxidative stress-related molecular clusters in …
quality of life, underscoring the urgency for biomarker identification and therapeutic
advancements. This study investigates oxidative stress-related molecular clusters in …
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Assessment of measurement repeatability by keratoconus severity using an OCT and Placido‐based tomographer
J Arbelaez, R Herber, JL Alio del Barrio, MC Arbelaez… - Acta Ophthalmologica, 2025… However, this technology has demonstrated limitations in measurement
repeatability, particularly in advanced keratoconus, and it applies … for keratoconus
screening using an anterior segment OCT coupled with Placido disc tomographer (MS …
J Arbelaez, R Herber, JL Alio del Barrio, MC Arbelaez… - Acta Ophthalmologica, 2025
… However, this technology has demonstrated limitations in measurement
repeatability, particularly in advanced keratoconus, and it applies … for keratoconus
screening using an anterior segment OCT coupled with Placido disc tomographer (MS …
repeatability, particularly in advanced keratoconus, and it applies … for keratoconus
screening using an anterior segment OCT coupled with Placido disc tomographer (MS …
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[HTML] Mendelian randomization and genetic analyses reveal causal roles of immune cells and inflammatory proteins in keratoconus
J Chen, Y Jia, X Qi - Scientific Reports, 2025Immunity and inflammation are implicated in the progression of keratoconus (KC),
but the causal relationships between inflammatory immune phenotypes and the
disease remain unclear. We conducted a comprehensive Mendelian randomization (MR) …
J Chen, Y Jia, X Qi - Scientific Reports, 2025
Immunity and inflammation are implicated in the progression of keratoconus (KC),
but the causal relationships between inflammatory immune phenotypes and the
disease remain unclear. We conducted a comprehensive Mendelian randomization (MR) …
but the causal relationships between inflammatory immune phenotypes and the
disease remain unclear. We conducted a comprehensive Mendelian randomization (MR) …
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Extracellular matrix proteins expression in advanced keratoconus and normal human cornea
P Sahay, F Habroosh, P Filippini, A Al Saadi… - Frontiers in MedicineBackground: The pre-Descemet's layer (Dua's layer) (PDL/DL) and the Descemet
membrane (DM) have the highest expression of elastin in normal corneas. Reduced
expression of elastin in the corneal stroma occurs in keratoconus (KC). This study …
P Sahay, F Habroosh, P Filippini, A Al Saadi… - Frontiers in Medicine
Background: The pre-Descemet's layer (Dua's layer) (PDL/DL) and the Descemet
membrane (DM) have the highest expression of elastin in normal corneas. Reduced
expression of elastin in the corneal stroma occurs in keratoconus (KC). This study …
membrane (DM) have the highest expression of elastin in normal corneas. Reduced
expression of elastin in the corneal stroma occurs in keratoconus (KC). This study …
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One-year clinical observation of epithelial-off accelerated corneal collagen cross-linking on the treatment of progressive keratoconus
J LU, P MA, C LAN - International Eye Science, 2025AIM: To assess the clinical efficacy and safety of epithelial-off accelerated corneal
collagen cross-linking (CXL) in the management of progressive keratoconus over 1
a period. METHODS: A retrospective pre-post self-controlled study. Data were …
J LU, P MA, C LAN - International Eye Science, 2025
AIM: To assess the clinical efficacy and safety of epithelial-off accelerated corneal
collagen cross-linking (CXL) in the management of progressive keratoconus over 1
a period. METHODS: A retrospective pre-post self-controlled study. Data were …
collagen cross-linking (CXL) in the management of progressive keratoconus over 1
a period. METHODS: A retrospective pre-post self-controlled study. Data were …
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Evaluating serum biomarkers in keratoconus: the role of PCPE-1 and PCPE-2 in collagen metabolism and disease progression
ZG Sağlam, M Yildirim, E Laloğlu - Graefe's Archive for Clinical and Experimental …, 2025… keratoconus and followed up between October 2023 and May 2024, and 65
healthy individuals. 65 patients diagnosed with keratoconus … This study aimed to
investigate the serum levels of PCPE-1 and PCPE-2 in patients with keratoconus …
ZG Sağlam, M Yildirim, E Laloğlu - Graefe's Archive for Clinical and Experimental …, 2025
… keratoconus and followed up between October 2023 and May 2024, and 65
healthy individuals. 65 patients diagnosed with keratoconus … This study aimed to
investigate the serum levels of PCPE-1 and PCPE-2 in patients with keratoconus …
healthy individuals. 65 patients diagnosed with keratoconus … This study aimed to
investigate the serum levels of PCPE-1 and PCPE-2 in patients with keratoconus …
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Keratoconus: A global review of screening programs with a special focus on Saudi Arabia
SO Alreshidi - Majmaah Journal of Health Sciences, 2025… Keratoconus is a progressive disease of the cornea in which the cornea thins and
becomes … Keratoconus is highly prevalent in Saudi Arabia with multifactorial
contributors including … Educating the public is the most crucial step to improving …
SO Alreshidi - Majmaah Journal of Health Sciences, 2025
… Keratoconus is a progressive disease of the cornea in which the cornea thins and
becomes … Keratoconus is highly prevalent in Saudi Arabia with multifactorial
contributors including … Educating the public is the most crucial step to improving …
becomes … Keratoconus is highly prevalent in Saudi Arabia with multifactorial
contributors including … Educating the public is the most crucial step to improving …
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[HTML] Machine learning-assisted early detection of keratoconus: a comparative analysis of corneal topography and biomechanical data
A Syta, A Podkowiński, T Chorągiewicz, R Karpiński… - Scientific Reports, 2025… Keratoconus is a progressive eye disease characterized by the thinning and …
identify keratoconus based on corneal topography and biomechanical data. We
collected a dataset comprising 144 corneal scans from adults aged 18–35, including …
A Syta, A Podkowiński, T Chorągiewicz, R Karpiński… - Scientific Reports, 2025
… Keratoconus is a progressive eye disease characterized by the thinning and …
identify keratoconus based on corneal topography and biomechanical data. We
collected a dataset comprising 144 corneal scans from adults aged 18–35, including …
identify keratoconus based on corneal topography and biomechanical data. We
collected a dataset comprising 144 corneal scans from adults aged 18–35, including …
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Assessing Endothelial Integrity in Patients With Progressive Keratoconus and Thin Corneas Treated With the Sub400 Corneal Cross-linking Protocol
F Blaser, EA Torres-Netto, Z Gatzioufas, P Perschak… - Journal of Refractive …, 2025… We identified patients treated for progressive keratoconus according to the
Sub400 protocol in our tertiary care facility between August 2021 and August 2024.
The local ethics committee signed a declaration of non-responsibility for this project (BASECNr …
F Blaser, EA Torres-Netto, Z Gatzioufas, P Perschak… - Journal of Refractive …, 2025
… We identified patients treated for progressive keratoconus according to the
Sub400 protocol in our tertiary care facility between August 2021 and August 2024.
The local ethics committee signed a declaration of non-responsibility for this project (BASECNr …
Sub400 protocol in our tertiary care facility between August 2021 and August 2024.
The local ethics committee signed a declaration of non-responsibility for this project (BASECNr …
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Corneal Densitometry and Higher Order Aberrations After Corneal Transplantation and Corneal Cross-Linking for Keratoconus: 3-Year Results
T Chen, M Liu, Y Lin, G Tian, C Liu, X Wu, S Li, X Qi… - Journal of Refractive …, 2025… keratoconus without obvious corneal scarring, in which a stromal button with a
diameter of 9 mm and a thickness of approximately 200 µm was inserted into an
intrastromal pocket.It has been proved that MILK can halt keratoconus … , and MILK …
T Chen, M Liu, Y Lin, G Tian, C Liu, X Wu, S Li, X Qi… - Journal of Refractive …, 2025
… keratoconus without obvious corneal scarring, in which a stromal button with a
diameter of 9 mm and a thickness of approximately 200 µm was inserted into an
intrastromal pocket.It has been proved that MILK can halt keratoconus … , and MILK …
diameter of 9 mm and a thickness of approximately 200 µm was inserted into an
intrastromal pocket.It has been proved that MILK can halt keratoconus … , and MILK …
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[PDF] Research progress of corneal collagen crosslinking in the treatment of keratoconus
W Xiaoxuan, S Fangfang, L Xiaopeng, L Junxiang… - International Review of …, 2025Abstract: Keratoconus (KC) is a common congenital, progressive, non-inflammatory
degenerative corneal disorder. Corneal collagen cross-linking can increase corneal
stiffness and control disease progression. Enhanced riboflavin penetration is …
W Xiaoxuan, S Fangfang, L Xiaopeng, L Junxiang… - International Review of …, 2025
Abstract: Keratoconus (KC) is a common congenital, progressive, non-inflammatory
degenerative corneal disorder. Corneal collagen cross-linking can increase corneal
stiffness and control disease progression. Enhanced riboflavin penetration is …
degenerative corneal disorder. Corneal collagen cross-linking can increase corneal
stiffness and control disease progression. Enhanced riboflavin penetration is …
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SYMPTOMS OF DEPRESSION AND ANXIETY IN KERATOCONUS PATIENT
SL Abbasi, RS Shahid, AW Mir, S Abdullah, M Javed… - 2025… Eye Hospital in Karachi, the purpose of this study was to determine how
frequently anxiety and depression occur in keratoconus patients. … of keratoconus.
Spearman's correlation was used to check the correlation between the severity of …
SL Abbasi, RS Shahid, AW Mir, S Abdullah, M Javed… - 2025
… Eye Hospital in Karachi, the purpose of this study was to determine how
frequently anxiety and depression occur in keratoconus patients. … of keratoconus.
Spearman's correlation was used to check the correlation between the severity of …
frequently anxiety and depression occur in keratoconus patients. … of keratoconus.
Spearman's correlation was used to check the correlation between the severity of …
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[PDF] Long-term efficacy of accelerated corneal collagen cross-linking for keratoconus
S Santhakumaran, WM Hopman, D Johnson - Canadian Journal of OphthalmologyKeratoconus is a progressive corneal disorder characterized by thinning and
steepening, leading to visual distortion and photophobia. … for keratoconus patients
treated with ACXL from 2019 to 2023 at Hotel Dieu Hospital, Kingston, Canada …
S Santhakumaran, WM Hopman, D Johnson - Canadian Journal of Ophthalmology
Keratoconus is a progressive corneal disorder characterized by thinning and
steepening, leading to visual distortion and photophobia. … for keratoconus patients
treated with ACXL from 2019 to 2023 at Hotel Dieu Hospital, Kingston, Canada …
steepening, leading to visual distortion and photophobia. … for keratoconus patients
treated with ACXL from 2019 to 2023 at Hotel Dieu Hospital, Kingston, Canada …
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The Vision Impact Survey for Keratoconus (VISYKO) for measuring the quality of life in patients with keratoconus
M Buzzi, R Mencucci, S Gallio, M Fruschelli… - 16th EuCornea Annual …, 2025… Survey for Keratoconus (VISYKO) as a patient- reported outcome (PRO) to
measure the vision-related quality of life (QoL) in keratoconus patients. Setting
University of Florence, University of Siena, Studio Italiano di Oftalmologia Methods …
M Buzzi, R Mencucci, S Gallio, M Fruschelli… - 16th EuCornea Annual …, 2025
… Survey for Keratoconus (VISYKO) as a patient- reported outcome (PRO) to
measure the vision-related quality of life (QoL) in keratoconus patients. Setting
University of Florence, University of Siena, Studio Italiano di Oftalmologia Methods …
measure the vision-related quality of life (QoL) in keratoconus patients. Setting
University of Florence, University of Siena, Studio Italiano di Oftalmologia Methods …
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[PDF] Corneal Topography Parameters and Tear Film Break-up Characteristics in Keratoconus Patients
D Wu, J Hong, S Wu, J Xu - British Journal of Hospital Medicine, 2025Aims/Background Previous studies have found that keratoconus (KC) patients are
highly susceptible to dry eye disease (DED); however, the specific relationship
between KC and DED has not been thoroughly investigated. This study aims to …
D Wu, J Hong, S Wu, J Xu - British Journal of Hospital Medicine, 2025
Aims/Background Previous studies have found that keratoconus (KC) patients are
highly susceptible to dry eye disease (DED); however, the specific relationship
between KC and DED has not been thoroughly investigated. This study aims to …
highly susceptible to dry eye disease (DED); however, the specific relationship
between KC and DED has not been thoroughly investigated. This study aims to …
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Investigating Prolactin-Induced Protein and its role in modulating the metabolic state of the keratoconus microenvironment
W Liang, B Vasini, J Clayton, JX Ma, D Karamichos - Experimental Eye Research, 2025Keratoconus (KC) is a progressive corneal disorder characterized by thinning and
irregular astigmatism, leading to visual impairment. This study investigates the role
of Prolactin-Induced Protein (PIP), a 17-kDa glycoprotein significantly …
W Liang, B Vasini, J Clayton, JX Ma, D Karamichos - Experimental Eye Research, 2025
Keratoconus (KC) is a progressive corneal disorder characterized by thinning and
irregular astigmatism, leading to visual impairment. This study investigates the role
of Prolactin-Induced Protein (PIP), a 17-kDa glycoprotein significantly …
irregular astigmatism, leading to visual impairment. This study investigates the role
of Prolactin-Induced Protein (PIP), a 17-kDa glycoprotein significantly …
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[HTML] Evaluation of refractive, tomographic and biomechanical changes after customized accelerated corneal collagen cross-linking in keratoconus patients: a retrospective …
RET Ang, AJA Guloy Jr, EM Cruz, JJGC Lo - BMC Ophthalmology, 2025… Keratoconus is treated using a variety of strategies. Options for treatment include
refractive correction using spectacles, contact lenses or … or halting the progression
of keratoconus, and in some cases, may even improve vision. As CXL slows down …
RET Ang, AJA Guloy Jr, EM Cruz, JJGC Lo - BMC Ophthalmology, 2025
… Keratoconus is treated using a variety of strategies. Options for treatment include
refractive correction using spectacles, contact lenses or … or halting the progression
of keratoconus, and in some cases, may even improve vision. As CXL slows down …
refractive correction using spectacles, contact lenses or … or halting the progression
of keratoconus, and in some cases, may even improve vision. As CXL slows down …
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[PDF] Reproducibility and Screening Capability of Corneal Epithelial Thickness Measurement for Keratoconus Using Anterior Segment Optical Coherence Tomography
T Oshika, A Sawaki, T Nishida, T Nakamura, T Kojima - Clinical Ophthalmology, 2025… epithelial thickness measurement in keratoconus eyes and compared corneal
epithelial thickness between keratoconus and normal eyes. … parameters for
diagnosing keratoconus. To our knowledge, this represents the first study evaluating …
T Oshika, A Sawaki, T Nishida, T Nakamura, T Kojima - Clinical Ophthalmology, 2025
… epithelial thickness measurement in keratoconus eyes and compared corneal
epithelial thickness between keratoconus and normal eyes. … parameters for
diagnosing keratoconus. To our knowledge, this represents the first study evaluating …
epithelial thickness between keratoconus and normal eyes. … parameters for
diagnosing keratoconus. To our knowledge, this represents the first study evaluating …
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The Role of Posterior Astigmatism in Keratoconus: Insights from a Systematic Review and Meta-Analysis
F Karimi, EM Ghaffary, M Farahani, F Stapleton… - … Ophthalmology & Visual …, 2025Purpose: Management of posterior astigmatism in keratoconus is still one of the
most relevant issues in corneal refractive surgery. Variability across stages should
be better understood with the response of surgical interventions to improve clinical …
F Karimi, EM Ghaffary, M Farahani, F Stapleton… - … Ophthalmology & Visual …, 2025
Purpose: Management of posterior astigmatism in keratoconus is still one of the
most relevant issues in corneal refractive surgery. Variability across stages should
be better understood with the response of surgical interventions to improve clinical …
most relevant issues in corneal refractive surgery. Variability across stages should
be better understood with the response of surgical interventions to improve clinical …
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[HTML] Normal Belin–Ambrosio display difference map in keratoconus
R Deshmukh - Indian Journal of Ophthalmology, 2025Corneal tomography is one of the most important diagnostic modalities used to
screen candidates for refractive surgery.[1] The Belin–Ambrosio enhanced ectasia
display (BAD) was developed as a screening tool to diagnose cases with early …
R Deshmukh - Indian Journal of Ophthalmology, 2025
Corneal tomography is one of the most important diagnostic modalities used to
screen candidates for refractive surgery.[1] The Belin–Ambrosio enhanced ectasia
display (BAD) was developed as a screening tool to diagnose cases with early …
screen candidates for refractive surgery.[1] The Belin–Ambrosio enhanced ectasia
display (BAD) was developed as a screening tool to diagnose cases with early …
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[HTML] Keratoconus detection in optical coherence tomography with deep learning classifiers
RM Hazarbassanov, L Weinketz, LA Dos Santos… - … Ophthalmology & Visual …, 2025… Data for suspected keratoconus and keratoconus were augmented to balance the
database. Maps were preprocessed to remove non-image objects and features were
extracted using the InceptionV3 architecture. These features were fed to five …
RM Hazarbassanov, L Weinketz, LA Dos Santos… - … Ophthalmology & Visual …, 2025
… Data for suspected keratoconus and keratoconus were augmented to balance the
database. Maps were preprocessed to remove non-image objects and features were
extracted using the InceptionV3 architecture. These features were fed to five …
database. Maps were preprocessed to remove non-image objects and features were
extracted using the InceptionV3 architecture. These features were fed to five …
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[HTML] Clinical outcomes of Bowman-Stromal inlay and corneal collagen crosslinking in contralateral eyes in patients with progressive keratoconus
N Jain, V Mittal, Y Pandya, V Yadav, V Shah… - Indian Journal of …, 2025… The results of BSI have shown promise in stabilizing keratoconus and improving
visual outcomes. [ 17 ] Although the number of … keratoconus. In the current study,
we aim to report the refractive and tomographic outcomes in a subset of patients with …
N Jain, V Mittal, Y Pandya, V Yadav, V Shah… - Indian Journal of …, 2025
… The results of BSI have shown promise in stabilizing keratoconus and improving
visual outcomes. [ 17 ] Although the number of … keratoconus. In the current study,
we aim to report the refractive and tomographic outcomes in a subset of patients with …
visual outcomes. [ 17 ] Although the number of … keratoconus. In the current study,
we aim to report the refractive and tomographic outcomes in a subset of patients with …
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[HTML] Progression in keratoconus: Are we looking for the right indexes?
LP Domínguez, SAM Tapia, IB Rodríguez… - … Ophthalmology & Visual …, 2025Purpose: Identification of keratoconus progression has been always a hot topic due
to its therapeutical impact. A group of long term refractive and visually stable
keratoconus were analyzed to look for changes in different corneal tomographical …
LP Domínguez, SAM Tapia, IB Rodríguez… - … Ophthalmology & Visual …, 2025
Purpose: Identification of keratoconus progression has been always a hot topic due
to its therapeutical impact. A group of long term refractive and visually stable
keratoconus were analyzed to look for changes in different corneal tomographical …
to its therapeutical impact. A group of long term refractive and visually stable
keratoconus were analyzed to look for changes in different corneal tomographical …
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[HTML] Contribution and compensation effects of refracting components to ocular aberrations in keratoconus
DA Atchison, SK Gupta, SA Read, A Carkeet… - … Ophthalmology & Visual …, 2025Purpose: To determine contributions of the eye's refracting components to ocular
aberrations in keratoconus (KC), the compensation of anterior corneal aberrations
by the posterior cornea, and of total corneal aberrations by the lens. Methods: There …
DA Atchison, SK Gupta, SA Read, A Carkeet… - … Ophthalmology & Visual …, 2025
Purpose: To determine contributions of the eye's refracting components to ocular
aberrations in keratoconus (KC), the compensation of anterior corneal aberrations
by the posterior cornea, and of total corneal aberrations by the lens. Methods: There …
aberrations in keratoconus (KC), the compensation of anterior corneal aberrations
by the posterior cornea, and of total corneal aberrations by the lens. Methods: There …
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[HTML] New approaches of intracorneal ring segments implantation for asymmetric keratoconus treatment: A case series
JSB Soares, BK Moscovici - Indian Journal of Ophthalmology, 2025Keratoconus is a corneal ectasia causing irregular astigmatism and visual
impairment. Intrastromal corneal ring segment (ICRS) implantation is reversible to
improve corneal shape and visual function. However, traditional nomograms often …
JSB Soares, BK Moscovici - Indian Journal of Ophthalmology, 2025
Keratoconus is a corneal ectasia causing irregular astigmatism and visual
impairment. Intrastromal corneal ring segment (ICRS) implantation is reversible to
improve corneal shape and visual function. However, traditional nomograms often …
impairment. Intrastromal corneal ring segment (ICRS) implantation is reversible to
improve corneal shape and visual function. However, traditional nomograms often …
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[HTML] Demographic and Comorbid Risk Factors Associated with Unstable Keratoconus
D Wilfand, A Fotinich, K Hsieh, S Raghupathy… - … Ophthalmology & Visual …, 2025Purpose: While risk factors for developing keratoconus (KC) are well understood,
factors related to severe disease are less recognized. This study identified
demographic and comorbid risk factors associated with unstable, severe KC …
D Wilfand, A Fotinich, K Hsieh, S Raghupathy… - … Ophthalmology & Visual …, 2025
Purpose: While risk factors for developing keratoconus (KC) are well understood,
factors related to severe disease are less recognized. This study identified
demographic and comorbid risk factors associated with unstable, severe KC …
factors related to severe disease are less recognized. This study identified
demographic and comorbid risk factors associated with unstable, severe KC …
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[HTML] Repeated corneal crosslinking for progressive keratoconus: efficiency and safety
E Chatzimichail, G Chondrozoumakis, F Doroodgar… - Therapeutic Advances in …, 2025… Hereby we aim to provide an overview of the literature on repeated CXL for
progressive keratoconus after failure of primary CXL, … , may be responsible for
keratoconus progression after primary CXL, while it also correlates with more severe …
E Chatzimichail, G Chondrozoumakis, F Doroodgar… - Therapeutic Advances in …, 2025
… Hereby we aim to provide an overview of the literature on repeated CXL for
progressive keratoconus after failure of primary CXL, … , may be responsible for
keratoconus progression after primary CXL, while it also correlates with more severe …
progressive keratoconus after failure of primary CXL, … , may be responsible for
keratoconus progression after primary CXL, while it also correlates with more severe …
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[HTML] Does Keratoconus Follow Rundle's Curve?
S Sahebjada, AA Moktar, S Vogrin, E Chan, PN Baird… - Journal of Clinical & …, 2025… Patients with keratoconus who underwent Pentacam tomography imaging from
the Australian Study of Keratoconus were included in this study. Patients who …
This study suggests keratoconus does not conform to the classic Rundle's curve of …
S Sahebjada, AA Moktar, S Vogrin, E Chan, PN Baird… - Journal of Clinical & …, 2025
… Patients with keratoconus who underwent Pentacam tomography imaging from
the Australian Study of Keratoconus were included in this study. Patients who …
This study suggests keratoconus does not conform to the classic Rundle's curve of …
the Australian Study of Keratoconus were included in this study. Patients who …
This study suggests keratoconus does not conform to the classic Rundle's curve of …
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[HTML] Changes in Corneal Keratocytes and Collagen Fibrils as an Indicator of Keratoconus Onset: A Preliminary Study Based on OCT Subchannel Images
FH Silver, D Benedetto, T Deshmukh - Frontiers in Bioscience-Landmark, 2025Background: Keratoconus (KC) is a corneal disease that causes changes in corneal
topography, leading to central/paracentral cone formation, which affects visual acuity.
Methods: We studied in vivo optical coherence tomography (OCT) images of normal …
FH Silver, D Benedetto, T Deshmukh - Frontiers in Bioscience-Landmark, 2025
Background: Keratoconus (KC) is a corneal disease that causes changes in corneal
topography, leading to central/paracentral cone formation, which affects visual acuity.
Methods: We studied in vivo optical coherence tomography (OCT) images of normal …
topography, leading to central/paracentral cone formation, which affects visual acuity.
Methods: We studied in vivo optical coherence tomography (OCT) images of normal …
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[PDF] Estrogen Mediated Corneal Collagen Degradation in Keratoconus
A Chatterjee, LN Kanu, N Boychev, AE Ross, V Yeung… - iScience, 2025Keratoconus (KC) is characterized by corneal thinning due to pathologic
degradation of corneal stromal collagen.. This study investigates the role of β-estradiol
in corneal collagen degradation using both tear fluid samples from KC and non-KC …
A Chatterjee, LN Kanu, N Boychev, AE Ross, V Yeung… - iScience, 2025
Keratoconus (KC) is characterized by corneal thinning due to pathologic
degradation of corneal stromal collagen.. This study investigates the role of β-estradiol
in corneal collagen degradation using both tear fluid samples from KC and non-KC …
degradation of corneal stromal collagen.. This study investigates the role of β-estradiol
in corneal collagen degradation using both tear fluid samples from KC and non-KC …
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[PDF] Quality of Life in Keratoconus Patients; A Comparison Between Spectacle, Rigid Gas-Permeable Lens, and Corneal Stromal Ring Segment Implantation
H Kangari, S Mohaghegh, S Bamdad - Beyoglu Eye Journal… management strategies for keratoconus patients, offering a … keratoconus patients
who had received appropriate optical or surgical treatments for more than 1 year.
The exclusion criteria included keratoconus patients with steep K < 45D or > 62D (mild …
H Kangari, S Mohaghegh, S Bamdad - Beyoglu Eye Journal
… management strategies for keratoconus patients, offering a … keratoconus patients
who had received appropriate optical or surgical treatments for more than 1 year.
The exclusion criteria included keratoconus patients with steep K < 45D or > 62D (mild …
who had received appropriate optical or surgical treatments for more than 1 year.
The exclusion criteria included keratoconus patients with steep K < 45D or > 62D (mild …
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[HTML] Highly efficient stacking ensemble learning model for automated keratoconus screening
ZJ Muhsin, R Qahwaji, I Ghafir, M AlShawabkeh… - Eye and Vision, 2025Despite extensive research on keratoconus (KC) detection with traditional machine
learning models, stacking ensemble learning approaches remain underexplored.
This paper presents a stacking ensemble learning method to enhance automated …
ZJ Muhsin, R Qahwaji, I Ghafir, M AlShawabkeh… - Eye and Vision, 2025
Despite extensive research on keratoconus (KC) detection with traditional machine
learning models, stacking ensemble learning approaches remain underexplored.
This paper presents a stacking ensemble learning method to enhance automated …
learning models, stacking ensemble learning approaches remain underexplored.
This paper presents a stacking ensemble learning method to enhance automated …
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[HTML] Vision related quality of life in keratoconus patients with intra stromal corneal ring segments implantation
S Mohaghegh, S Bamdad, H Kangari, MR Khalili… - Oman Journal of …, 2025… [ 4-6 ] It has been reported that keratoconus patients had worse quality-of-life
scores than … [ 21 ] In the current study, we aim to compare the vision-related
quality of life in keratoconus … insight into the management strategies of …
S Mohaghegh, S Bamdad, H Kangari, MR Khalili… - Oman Journal of …, 2025
… [ 4-6 ] It has been reported that keratoconus patients had worse quality-of-life
scores than … [ 21 ] In the current study, we aim to compare the vision-related
quality of life in keratoconus … insight into the management strategies of …
scores than … [ 21 ] In the current study, we aim to compare the vision-related
quality of life in keratoconus … insight into the management strategies of …
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[HTML] Partial Endothelial Trepanation versus Deep Anterior Lamellar Keratoplasty in keratoconus patients: Results of the PENTACON trial
RPL Wisse, CA Eggink, BTH van Dooren… - Journal of Trial & Error, 2025The purpose of this research was to report on the surgical safety and outcomes of
two distinct techniques of anterior lamellar corneal surgery: the Big Bubble Deep
Anterior Lamellar Keratoplasty (DALK) versus Busin's Partial ENdothelial …
RPL Wisse, CA Eggink, BTH van Dooren… - Journal of Trial & Error, 2025
The purpose of this research was to report on the surgical safety and outcomes of
two distinct techniques of anterior lamellar corneal surgery: the Big Bubble Deep
Anterior Lamellar Keratoplasty (DALK) versus Busin's Partial ENdothelial …
two distinct techniques of anterior lamellar corneal surgery: the Big Bubble Deep
Anterior Lamellar Keratoplasty (DALK) versus Busin's Partial ENdothelial …
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FEMTOSECOND-ASSISTED DEEP ANTERIOR LAMELLAR KERATOPLASTY FOR KERATOCONUS: CONTEMPORARY CLINICAL PERSPECTIVES AND …
KM Kh, MI Inomzhonova, SI Abdullaeva - Central Asian Journal of Medicine, 2025… We conducted a retrospective analysis of 12 patients aged 18-42 years with stage
III keratoconus who underwent femto-DALK between 2023-2024. Primary outcome
measures included visual acuity, refractive outcomes, keratotopographic parameters …
KM Kh, MI Inomzhonova, SI Abdullaeva - Central Asian Journal of Medicine, 2025
… We conducted a retrospective analysis of 12 patients aged 18-42 years with stage
III keratoconus who underwent femto-DALK between 2023-2024. Primary outcome
measures included visual acuity, refractive outcomes, keratotopographic parameters …
III keratoconus who underwent femto-DALK between 2023-2024. Primary outcome
measures included visual acuity, refractive outcomes, keratotopographic parameters …
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Pediatric Keratoconus Diagnosis by Corneal Tomography
ACR Zuazo - Highlights of Ophthalmology, 2025… to determine the model's ability to discriminate between healthy and keratoconus
corneas. Resultados: The study included 28 parameters (… for diagnosing
keratoconus. Conclusion: The parameters with the highest sensitivity and specificity …
ACR Zuazo - Highlights of Ophthalmology, 2025
… to determine the model's ability to discriminate between healthy and keratoconus
corneas. Resultados: The study included 28 parameters (… for diagnosing
keratoconus. Conclusion: The parameters with the highest sensitivity and specificity …
corneas. Resultados: The study included 28 parameters (… for diagnosing
keratoconus. Conclusion: The parameters with the highest sensitivity and specificity …
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[PDF] Advances in IOL calculations in patients with keratoconus
A Gershoni, GD Barrett, R Sella - Therapeutic Advances in Ophthalmology, 2025… This review examines the impact of keratoconus on IOL calculations and
highlights recent advancements in formulas specifically designed … AI-based and
keratoconus-specific IOL formulas, this review examines recent studies on IOL …
A Gershoni, GD Barrett, R Sella - Therapeutic Advances in Ophthalmology, 2025
… This review examines the impact of keratoconus on IOL calculations and
highlights recent advancements in formulas specifically designed … AI-based and
keratoconus-specific IOL formulas, this review examines recent studies on IOL …
highlights recent advancements in formulas specifically designed … AI-based and
keratoconus-specific IOL formulas, this review examines recent studies on IOL …
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Keratoconus associated with allergic diseases of the eye surface in pediatric practice
MM Bikbov, KK Titoyan, AR Khalimov, EL UsubovKeratoconus (KC) is a disease of the cornea characterized by its thinning and
deformation. Typically, KC causes a significant deterioration in corrected and
uncorrected visual acuity (in children of puberty and post-puberty ages among others) …
MM Bikbov, KK Titoyan, AR Khalimov, EL Usubov
Keratoconus (KC) is a disease of the cornea characterized by its thinning and
deformation. Typically, KC causes a significant deterioration in corrected and
uncorrected visual acuity (in children of puberty and post-puberty ages among others) …
deformation. Typically, KC causes a significant deterioration in corrected and
uncorrected visual acuity (in children of puberty and post-puberty ages among others) …
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[HTML] Long-term Outcomes of Transepithelial Accelerated Corneal Collagen Crosslinking in Patients with Progressive Keratoconus
R Vilares-Morgado, AM Ferreira, AM Cunha, R Moreira… - … Sociedade Portuguesa de …, 2025INTRODUÇÃO: Avaliação sistematizada da efetividade a longo prazo do
crosslinking transepitelial acelerado (TE-ACXL) no tratamento de olhos com
queratocone (KC) progressivo, ao longo de um período de 4 anos. MÉTODOS …
R Vilares-Morgado, AM Ferreira, AM Cunha, R Moreira… - … Sociedade Portuguesa de …, 2025
INTRODUÇÃO: Avaliação sistematizada da efetividade a longo prazo do
crosslinking transepitelial acelerado (TE-ACXL) no tratamento de olhos com
queratocone (KC) progressivo, ao longo de um período de 4 anos. MÉTODOS …
crosslinking transepitelial acelerado (TE-ACXL) no tratamento de olhos com
queratocone (KC) progressivo, ao longo de um período de 4 anos. MÉTODOS …
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Shared molecular profiles of post-laser vision correction ectasia and keratoconus with key differences in CADPS, CPT1B, CIITA, and TBC1D4
K Jaskiewicz-Rajewicz, A Wysocka… - Frontiers in Molecular BiosciencesPost-laser vision correction (post-LVC) ectasia is a serious complication of 0.033-0.66%
of corneal refractive surgeries. Post-LVC ectasia, likewise keratoconus (KTCN) is
classified under the "ectatic diseases" category. We hypothesize that, although the …
K Jaskiewicz-Rajewicz, A Wysocka… - Frontiers in Molecular Biosciences
Post-laser vision correction (post-LVC) ectasia is a serious complication of 0.033-0.66%
of corneal refractive surgeries. Post-LVC ectasia, likewise keratoconus (KTCN) is
classified under the "ectatic diseases" category. We hypothesize that, although the …
of corneal refractive surgeries. Post-LVC ectasia, likewise keratoconus (KTCN) is
classified under the "ectatic diseases" category. We hypothesize that, although the …
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POS0421-HPR INVESTIGATING SJÖGREN'S SYNDROME AS A RISK FACTOR FOR KERATOCONUS: A NATIONWIDE STUDY EMPLOYING A NESTED CASE …
LC See, PH Tsai, WM Chen, KK Lin, JS Lee - Annals of the Rheumatic Diseases, 2025Background: Keratoconus (KC) is a bilateral, progressive, non-inflammatory thinning
and ectasia of the cornea. While traditionally considered non-inflammatory, recent
studies have shown a positive association between KC and multiple immune-mediated …
LC See, PH Tsai, WM Chen, KK Lin, JS Lee - Annals of the Rheumatic Diseases, 2025
Background: Keratoconus (KC) is a bilateral, progressive, non-inflammatory thinning
and ectasia of the cornea. While traditionally considered non-inflammatory, recent
studies have shown a positive association between KC and multiple immune-mediated …
and ectasia of the cornea. While traditionally considered non-inflammatory, recent
studies have shown a positive association between KC and multiple immune-mediated …
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Outcomes of Photorefractive Keratectomy in First-Degree Relatives of Patients With Keratoconus
S Feizi, MA Javadi, K Bayat, H Babaei, M Fallahzadeh… - CorneaPurpose The aim of this study was to evaluate the safety and efficacy of
photorefractive keratectomy (PRK) for treating myopic astigmatism in first-degree
relatives of patients with keratoconus. Methods This retrospective comparative …
S Feizi, MA Javadi, K Bayat, H Babaei, M Fallahzadeh… - Cornea
Purpose The aim of this study was to evaluate the safety and efficacy of
photorefractive keratectomy (PRK) for treating myopic astigmatism in first-degree
relatives of patients with keratoconus. Methods This retrospective comparative …
photorefractive keratectomy (PRK) for treating myopic astigmatism in first-degree
relatives of patients with keratoconus. Methods This retrospective comparative …
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[PDF] TEAR CARNITINE ANALYSIS AFTER CORNEAL CROSSLINKING IN KERATOCONUS: Carnitine analysis in keratoconus
A Sağlık, MU Işık, F Sağlık, İ Koyuncu - International Journal of Current Medical and …, 2025… of keratoconus has not … in keratoconus and healthy corneas, increased
carnitine synthesis activity was reported in corneas with keraconus (17). As a matter
of fact that, significantly reduced carnitine levels in keratoconus corneas were …
carnitine synthesis activity was reported in corneas with keraconus (17). As a matter
of fact that, significantly reduced carnitine levels in keratoconus corneas were …
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[HTML] Shield ulcer in keratoconus in the absence of atopic or vernal kerato-conjunctivitis
M Niestrata, S Kohli, M Saleki, Z Ashena - 2025Corneal shield ulcer is a severe complication of atopic keratoconjunctivitis (AKC)
and vernal keratoconjunctivitis (VKC). This condition is caused by the mechanical
irritation of the corneal epithelium due to giant papillae and toxic epitheliopathy …
M Niestrata, S Kohli, M Saleki, Z Ashena - 2025
Corneal shield ulcer is a severe complication of atopic keratoconjunctivitis (AKC)
and vernal keratoconjunctivitis (VKC). This condition is caused by the mechanical
irritation of the corneal epithelium due to giant papillae and toxic epitheliopathy …
and vernal keratoconjunctivitis (VKC). This condition is caused by the mechanical
irritation of the corneal epithelium due to giant papillae and toxic epitheliopathy …
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[PDF] Exploring the Impact of Intraocular Higher Order Aberrations on Customized Refractive Surgery in Keratoconus
F Li, B Sun - Journal of Refractive Surgery, 2025… calculation of intraocular HOAs in patients with keratoconus. They assert that
taking these … , would enhance the visual quality for patients with keratoconus.
However, the authors have not … this interaction might vary across different stages …
F Li, B Sun - Journal of Refractive Surgery, 2025
… calculation of intraocular HOAs in patients with keratoconus. They assert that
taking these … , would enhance the visual quality for patients with keratoconus.
However, the authors have not … this interaction might vary across different stages …
taking these … , would enhance the visual quality for patients with keratoconus.
However, the authors have not … this interaction might vary across different stages …
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[HTML] Corneal crosslinking for keratoconus in children with thin corneas: A multicentre registry study
CJ Proxenos, H Kandel, A Gupta, JY Chen, A Watson… - AJO International, 2025Purpose This study reports the clinical outcomes of corneal crosslinking in children
with thin corneas in the real-world setting. Design Retrospective, longitudinal study
Subjects The subjects were extracted from the Save Sight Keratoconus Registry and …
CJ Proxenos, H Kandel, A Gupta, JY Chen, A Watson… - AJO International, 2025
Purpose This study reports the clinical outcomes of corneal crosslinking in children
with thin corneas in the real-world setting. Design Retrospective, longitudinal study
Subjects The subjects were extracted from the Save Sight Keratoconus Registry and …
with thin corneas in the real-world setting. Design Retrospective, longitudinal study
Subjects The subjects were extracted from the Save Sight Keratoconus Registry and …
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[HTML] Detection of Keratoconus through YOLOv8 Region of Interest Preprocessing and Pre-trained Convolutional Neural Networks Using 2D Images
MS Anwar, E Özbilge - Cyprus Journal of Medical Sciences, 2025… a methodology for detecting keratoconus using pre-trained … keratoconus
detection approach using YOLOv8 for ROI extraction and CNN-based classification
to improve the diagnostic performance. This study aimed to develop an advanced …
MS Anwar, E Özbilge - Cyprus Journal of Medical Sciences, 2025
… a methodology for detecting keratoconus using pre-trained … keratoconus
detection approach using YOLOv8 for ROI extraction and CNN-based classification
to improve the diagnostic performance. This study aimed to develop an advanced …
detection approach using YOLOv8 for ROI extraction and CNN-based classification
to improve the diagnostic performance. This study aimed to develop an advanced …
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Visual and keratometric outcomes following corneal collagen cross-linking in keratoconus: an experience from Nepal
NK Barnwal, SK Sah, B Chaudhary, PR Adhikari… - … hypothesis, discovery & …, 2025… Background: Keratoconus is a progressive corneal ectasia causing visual
impairment, often initially managed using spectacles or rigid … keratoconus.
Methods: This retrospective, hospital-based study analyzed visual acuity and …
NK Barnwal, SK Sah, B Chaudhary, PR Adhikari… - … hypothesis, discovery & …, 2025
… Background: Keratoconus is a progressive corneal ectasia causing visual
impairment, often initially managed using spectacles or rigid … keratoconus.
Methods: This retrospective, hospital-based study analyzed visual acuity and …
impairment, often initially managed using spectacles or rigid … keratoconus.
Methods: This retrospective, hospital-based study analyzed visual acuity and …
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Corneal surface changes after stromal lenticule addition keratoplasty combined with cross-linking for severe keratoconus
XY Sun, D Shen, HX Chen, WJ Cao, K Zhou, YN Wang… - International Journal of …, 2025AIM To investigate the response of the anterior and posterior corneal surface in
femtosecond laser-assisted convex stromal lenticule addition keratoplasty (SLAK)
combined with cross-linking (CXL) for treating keratoconus at the first 3mo of follow-up …
XY Sun, D Shen, HX Chen, WJ Cao, K Zhou, YN Wang… - International Journal of …, 2025
AIM To investigate the response of the anterior and posterior corneal surface in
femtosecond laser-assisted convex stromal lenticule addition keratoplasty (SLAK)
combined with cross-linking (CXL) for treating keratoconus at the first 3mo of follow-up …
femtosecond laser-assisted convex stromal lenticule addition keratoplasty (SLAK)
combined with cross-linking (CXL) for treating keratoconus at the first 3mo of follow-up …
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[HTML] Corneal Collagen Crosslinking and Vision-Related Quality of Life: Outcomes in Keratoconus Patients
M Francisco, E Garcês, J Gil, E Costa, A Rosa… - … Sociedade Portuguesa de …, 2025INTRODUÇÃO: O queratocone é uma doença ectásica progressiva da córnea com
um impacto significativo na qualidade de vida dos doentes. Este estudo tem como
objetivo avaliar o efeito do crosslinking (CXL) na qualidade de vida relacionada …
M Francisco, E Garcês, J Gil, E Costa, A Rosa… - … Sociedade Portuguesa de …, 2025
INTRODUÇÃO: O queratocone é uma doença ectásica progressiva da córnea com
um impacto significativo na qualidade de vida dos doentes. Este estudo tem como
objetivo avaliar o efeito do crosslinking (CXL) na qualidade de vida relacionada …
um impacto significativo na qualidade de vida dos doentes. Este estudo tem como
objetivo avaliar o efeito do crosslinking (CXL) na qualidade de vida relacionada …
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[HTML] Combined femtosecond intrastromal lenticular implantation and corneal crosslinking to treat advanced keratoconus: a 6-month observation including epithelial …
Y Dong, J Zhang, Y Xu, L Xu, F Sun, J Hou, Z Ma, Y Lei - BMC ophthalmology, 2025… Nine eyes from eight patients with advanced keratoconus were included in this …
6 months postoperatively for all involved keratoconus patients. Corneal
biomechanical properties … biomechanics of advanced keratoconus, and prevented …
Y Dong, J Zhang, Y Xu, L Xu, F Sun, J Hou, Z Ma, Y Lei - BMC ophthalmology, 2025
… Nine eyes from eight patients with advanced keratoconus were included in this …
6 months postoperatively for all involved keratoconus patients. Corneal
biomechanical properties … biomechanics of advanced keratoconus, and prevented …
6 months postoperatively for all involved keratoconus patients. Corneal
biomechanical properties … biomechanics of advanced keratoconus, and prevented …
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Prevalence and clinical characteristics of Keratoconus amongst school children in Mumbai
N Chaurasia, VR Moodley, KP Mashige - Contact Lens and Anterior Eye, 2025Purpose To determine the prevalence and characterize the clinical profile of
keratoconus [KC] among Mumbai schoolchildren. Methods A sample of 2 042
students aged 9–17 years was selected from schools in Mumbai through stratified …
N Chaurasia, VR Moodley, KP Mashige - Contact Lens and Anterior Eye, 2025
Purpose To determine the prevalence and characterize the clinical profile of
keratoconus [KC] among Mumbai schoolchildren. Methods A sample of 2 042
students aged 9–17 years was selected from schools in Mumbai through stratified …
keratoconus [KC] among Mumbai schoolchildren. Methods A sample of 2 042
students aged 9–17 years was selected from schools in Mumbai through stratified …
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An evaluation of anterior segment and corneal changes during the valsalva maneuver in keratoconus patients with and without corneal cross-linking
Ç Mutaf, I Uzun, AH Reyhan, F Yüksekyayla - International Ophthalmology, 2025… The diagnosis of keratoconus is of great importance in order to perform collagen
corneal cross-linking (CXL) to strengthen the cornea. … with keratoconus. However,
studies concerning the effects of the Valsalva maneuver on anterior segment …
Ç Mutaf, I Uzun, AH Reyhan, F Yüksekyayla - International Ophthalmology, 2025
… The diagnosis of keratoconus is of great importance in order to perform collagen
corneal cross-linking (CXL) to strengthen the cornea. … with keratoconus. However,
studies concerning the effects of the Valsalva maneuver on anterior segment …
corneal cross-linking (CXL) to strengthen the cornea. … with keratoconus. However,
studies concerning the effects of the Valsalva maneuver on anterior segment …
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Clinical factors affecting corneal epithelial healing after epithelium-off collagen cross-linking in patients with keratoconus: a prospective cohort study
J Sun, F Li, X Wang, W Shi, T Wang - International Ophthalmology, 2025… Studies on corneal epithelial features in keratoconus have demonstrated that the
epithelium is markedly thinner and exhibits greater variability compared to normal
eyes [23], and the epithelial thickness at the steeper points was thinner than that at …
J Sun, F Li, X Wang, W Shi, T Wang - International Ophthalmology, 2025
… Studies on corneal epithelial features in keratoconus have demonstrated that the
epithelium is markedly thinner and exhibits greater variability compared to normal
eyes [23], and the epithelial thickness at the steeper points was thinner than that at …
epithelium is markedly thinner and exhibits greater variability compared to normal
eyes [23], and the epithelial thickness at the steeper points was thinner than that at …
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Efficacy of implantable Collamer lens after corneal cross-linking in patients with keratoconus: a systematic review and meta-analysis
AF Elgazzar, E Tharwat, S Diab, WS Abdella… - International Ophthalmology, 2025… We included all relevant studies that reported the efficacy of toric ICL after CXL in
keratoconus patients. The primary outcomes were uncorrected distance visual acuity
(UDVA), corrected distance visual acuity (CDVA), manifest refraction (sphere …
AF Elgazzar, E Tharwat, S Diab, WS Abdella… - International Ophthalmology, 2025
… We included all relevant studies that reported the efficacy of toric ICL after CXL in
keratoconus patients. The primary outcomes were uncorrected distance visual acuity
(UDVA), corrected distance visual acuity (CDVA), manifest refraction (sphere …
keratoconus patients. The primary outcomes were uncorrected distance visual acuity
(UDVA), corrected distance visual acuity (CDVA), manifest refraction (sphere …
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Effect of apical clearance rigid corneal contact lens fitting on keratoconus progression: a controlled longitudinal analysis
TH Tsai, JH Hsu, CC Sun, CH Hsiao, JS Lee, KK Lin - Contact Lens and Anterior Eye, 2025Purpose To evaluate the impact of apical clearance rigid corneal contact lens (RCCL)
fitting on keratoconus (KC) progression compared to untreated KC patients over a 12-month
period. Methods This retrospective, controlled longitudinal study included 237 eyes …
TH Tsai, JH Hsu, CC Sun, CH Hsiao, JS Lee, KK Lin - Contact Lens and Anterior Eye, 2025
Purpose To evaluate the impact of apical clearance rigid corneal contact lens (RCCL)
fitting on keratoconus (KC) progression compared to untreated KC patients over a 12-month
period. Methods This retrospective, controlled longitudinal study included 237 eyes …
fitting on keratoconus (KC) progression compared to untreated KC patients over a 12-month
period. Methods This retrospective, controlled longitudinal study included 237 eyes …
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[HTML] Incidence of steroid-induced ocular hypertension following collagen cross-linking in patients with keratoconus
TS Krishna, PM George, AB John, A Sen, JS Rose… - The Pan-American Journal …, 2025Purpose: Collagen cross-linking (CXL) is commonly performed to halt/delay the
progression of keratoconus (KC). Topical steroid drops are used at relatively high
doses post-CXL to prevent postprocedure corneal scarring. Many factors have been …
TS Krishna, PM George, AB John, A Sen, JS Rose… - The Pan-American Journal …, 2025
Purpose: Collagen cross-linking (CXL) is commonly performed to halt/delay the
progression of keratoconus (KC). Topical steroid drops are used at relatively high
doses post-CXL to prevent postprocedure corneal scarring. Many factors have been …
progression of keratoconus (KC). Topical steroid drops are used at relatively high
doses post-CXL to prevent postprocedure corneal scarring. Many factors have been …
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[PDF] The effectiveness of various methods for excimer laser interventions in the comprehensive treatment of keratoconus
IV Afanasyev - Archive of Ukrainian Ophthalmology, 2025Background. Keratoconus is a degenerative disease that results in progressive
vision deterioration, reduced visual acuity, inability to use standard optical methods
for correcting ametropia, and, in some cases, blindness. The prevalence of this …
IV Afanasyev - Archive of Ukrainian Ophthalmology, 2025
Background. Keratoconus is a degenerative disease that results in progressive
vision deterioration, reduced visual acuity, inability to use standard optical methods
for correcting ametropia, and, in some cases, blindness. The prevalence of this …
vision deterioration, reduced visual acuity, inability to use standard optical methods
for correcting ametropia, and, in some cases, blindness. The prevalence of this …
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[HTML] Determination of serum homocysteine, folic acid, Vitamin D3, and thyroid profile in keratoconus patients
RC Sadananda, S Johri, GS Babu, R Sirisha - The Pan-American Journal of …, 2025… Keratoconus (KC) is a progressive noninflammatory disorder characterized by
central or paracentral corneal stromal thinning, which leads to apical protrusion and
irregular astigmatism, usually inferiorly. [ 1 ] It is a common cause of "unexplained" …
RC Sadananda, S Johri, GS Babu, R Sirisha - The Pan-American Journal of …, 2025
… Keratoconus (KC) is a progressive noninflammatory disorder characterized by
central or paracentral corneal stromal thinning, which leads to apical protrusion and
irregular astigmatism, usually inferiorly. [ 1 ] It is a common cause of "unexplained" …
central or paracentral corneal stromal thinning, which leads to apical protrusion and
irregular astigmatism, usually inferiorly. [ 1 ] It is a common cause of "unexplained" …
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[PDF] Evaluation of progression predictability with systemic inflammatory biomarkers in keratoconus patients
B Akbulut Yagci, H Erdal, E Uyar, M Deniz - Med Science, 2025… This research aimed to assess the association between keratoconus (KC)
progression and systemic inflammation markers. Additionally, we … Our research
revealed a notable correlation between elevated inflammatory biomarkers and …
B Akbulut Yagci, H Erdal, E Uyar, M Deniz - Med Science, 2025
… This research aimed to assess the association between keratoconus (KC)
progression and systemic inflammation markers. Additionally, we … Our research
revealed a notable correlation between elevated inflammatory biomarkers and …
progression and systemic inflammation markers. Additionally, we … Our research
revealed a notable correlation between elevated inflammatory biomarkers and …
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[HTML] Using Artificial Intelligence for an Efficient Prediction of Outcomes of Deep Anterior Lamellar Keratoplasty (DALK) in Advanced Keratoconus
G Kundu, S D'Souza, D Modak, S Balaraj, R Shetty… - Translational Vision Science …, 2025Purpose: To identify and analyze clinical risk factors and imaging parameters
influencing the outcomes of deep anterior lamellar keratoplasty (DALK) for
advanced keratoconus (KC) using an artificial intelligence (AI) model. Methods: This …
G Kundu, S D'Souza, D Modak, S Balaraj, R Shetty… - Translational Vision Science …, 2025
Purpose: To identify and analyze clinical risk factors and imaging parameters
influencing the outcomes of deep anterior lamellar keratoplasty (DALK) for
advanced keratoconus (KC) using an artificial intelligence (AI) model. Methods: This …
influencing the outcomes of deep anterior lamellar keratoplasty (DALK) for
advanced keratoconus (KC) using an artificial intelligence (AI) model. Methods: This …
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[HTML] Tear Proteomic Analysis From Offspring of Keratoconus Patients: New Insights Into Corneal Biomechanical Weakness and Disease Risk Stages
M López-López, U Regueiro, S Bravo, C Pena… - … Ophthalmology & Visual …, 2025Purpose: To analyze the tear proteome of keratoconus offspring (O-KC) and assess
the molecular drivers underlying corneal biomechanical weakening at KC-risk stages.
Methods: This cross-sectional study included 80 O-KC young participants and 42 …
M López-López, U Regueiro, S Bravo, C Pena… - … Ophthalmology & Visual …, 2025
Purpose: To analyze the tear proteome of keratoconus offspring (O-KC) and assess
the molecular drivers underlying corneal biomechanical weakening at KC-risk stages.
Methods: This cross-sectional study included 80 O-KC young participants and 42 …
the molecular drivers underlying corneal biomechanical weakening at KC-risk stages.
Methods: This cross-sectional study included 80 O-KC young participants and 42 …
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Assessment of Cardiac Functions in Patients With Keratoconus Using Two-Dimensional Speckle-Tracking Echocardiography and Three-Dimensional …
M Demirci, B Ozben, S Karaca, N Sayar, F Esen… - … (Mount Kisco, NY), 2025Background Keratoconus (KC) is a multifactorial disease characterized by
progressive corneal thinning and structural deformation. Despite being an
ophthalmological disorder, KC is proposed to have systemic implications. The aim of …
M Demirci, B Ozben, S Karaca, N Sayar, F Esen… - … (Mount Kisco, NY), 2025
Background Keratoconus (KC) is a multifactorial disease characterized by
progressive corneal thinning and structural deformation. Despite being an
ophthalmological disorder, KC is proposed to have systemic implications. The aim of …
progressive corneal thinning and structural deformation. Despite being an
ophthalmological disorder, KC is proposed to have systemic implications. The aim of …
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Extracorneal connective tissue alterations in keratoconus: ultrasonographic evaluation of tendon, plantar fascia, and cartilage
A Uysal, Ç İlhan, ME Uysal, T Gül, M Güzel - International ophthalmology, 2025… Conclusion: This study clearly demonstrates that patients with keratoconus have
significant PF, tendon and cartilage thickness abnormalities. Keratoconus patients
may have a tendency to develop conditions such as Achilles tendinitis, plantar …
A Uysal, Ç İlhan, ME Uysal, T Gül, M Güzel - International ophthalmology, 2025
… Conclusion: This study clearly demonstrates that patients with keratoconus have
significant PF, tendon and cartilage thickness abnormalities. Keratoconus patients
may have a tendency to develop conditions such as Achilles tendinitis, plantar …
significant PF, tendon and cartilage thickness abnormalities. Keratoconus patients
may have a tendency to develop conditions such as Achilles tendinitis, plantar …
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Polymorphous Corneal Dystrophy Subtype 3 and Keratoconus aggravation after corneal refractive surgery in a three-generation family carrying both ZEB1 and …
Q Lin, X Wang, X Peng, X Han, X Zhang, L Sun… - Frontiers in GeneticsBackground: This study reports a three-generation Chinese family with
polymorphous corneal dystrophy subtype 3 (PPCD3) and keratoconus (KC)
aggravation induced by corneal refractive surgery, specifically small incision …
Q Lin, X Wang, X Peng, X Han, X Zhang, L Sun… - Frontiers in Genetics
Background: This study reports a three-generation Chinese family with
polymorphous corneal dystrophy subtype 3 (PPCD3) and keratoconus (KC)
aggravation induced by corneal refractive surgery, specifically small incision …
polymorphous corneal dystrophy subtype 3 (PPCD3) and keratoconus (KC)
aggravation induced by corneal refractive surgery, specifically small incision …
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[HTML] Unraveling the Link Between Obesity and Keratoconus Risk Based on Genetic Evidence
Y Huang, J Zhuang, C Liu, S Liu, H Ren, Q Zhang, Y Li… - Translational Vision Science …, 2025Purpose: Keratoconus (KCN) is a progressive corneal disorder leading to vision
impairment. While genetic and environmental factors contribute to its development,
the role of obesity in KCN risk remains unclear. This study aimed to estimate the …
Y Huang, J Zhuang, C Liu, S Liu, H Ren, Q Zhang, Y Li… - Translational Vision Science …, 2025
Purpose: Keratoconus (KCN) is a progressive corneal disorder leading to vision
impairment. While genetic and environmental factors contribute to its development,
the role of obesity in KCN risk remains unclear. This study aimed to estimate the …
impairment. While genetic and environmental factors contribute to its development,
the role of obesity in KCN risk remains unclear. This study aimed to estimate the …
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[PDF] Periocular Vitiligo in Keratoconus: A Case Report and Literature Review
S Azizi, O Jamall, Z Jarrar, D Gore, O Findl - Cureus, 2025… Keratoconus is the most common reason for young patients requiring corneal
transplantation [3]. … This is the first case report of keratoconus in a patient with
periocular vitiligo who was using topical therapy known to exacerbate eye rubbing, a …
S Azizi, O Jamall, Z Jarrar, D Gore, O Findl - Cureus, 2025
… Keratoconus is the most common reason for young patients requiring corneal
transplantation [3]. … This is the first case report of keratoconus in a patient with
periocular vitiligo who was using topical therapy known to exacerbate eye rubbing, a …
transplantation [3]. … This is the first case report of keratoconus in a patient with
periocular vitiligo who was using topical therapy known to exacerbate eye rubbing, a …
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[HTML] Progression of keratoconus in the contralateral eye following acute corneal hydrops: A retrospective study
JS Lewis, CNJ McGhee, J Meyer - PloS one, 2025… Keratoconus is a progressive eye disease characterised by thinning and bulging
of the cornea, leading to distorted vision. Acute … of keratoconus in the contralateral
eye in a series of patients presenting with acute corneal hydrops at two major tertiary …
JS Lewis, CNJ McGhee, J Meyer - PloS one, 2025
… Keratoconus is a progressive eye disease characterised by thinning and bulging
of the cornea, leading to distorted vision. Acute … of keratoconus in the contralateral
eye in a series of patients presenting with acute corneal hydrops at two major tertiary …
of the cornea, leading to distorted vision. Acute … of keratoconus in the contralateral
eye in a series of patients presenting with acute corneal hydrops at two major tertiary …
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[HTML] Translation, cross-cultural adaptation, and validation of the Norwegian version of the Keratoconus Outcomes Research Questionnaire
E Lundanes, SM Roten, HK Falkenberg, L Leren… - Journal of Patient-Reported …, 2025To translate and adapt the Keratoconus Outcomes Research questionnaire (KORQ)
to Norwegian language, culture, and environment, and to validate the translated
version in a Norwegian population with keratoconus. KORQ was translated to …
E Lundanes, SM Roten, HK Falkenberg, L Leren… - Journal of Patient-Reported …, 2025
To translate and adapt the Keratoconus Outcomes Research questionnaire (KORQ)
to Norwegian language, culture, and environment, and to validate the translated
version in a Norwegian population with keratoconus. KORQ was translated to …
to Norwegian language, culture, and environment, and to validate the translated
version in a Norwegian population with keratoconus. KORQ was translated to …
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[HTML] Catching the Curve: The Essentials to Early Keratoconus Diagnosis
OD Mitch Ibach, TS SwartzCharacterized by progressive corneal thinning and conical protrusion, keratoconus
is an ectatic corneal disorder. Early diagnosis is crucial, as keratoconus can present
complications for vision—including myopia and irregular astigmatism—and surgical …
OD Mitch Ibach, TS Swartz
Characterized by progressive corneal thinning and conical protrusion, keratoconus
is an ectatic corneal disorder. Early diagnosis is crucial, as keratoconus can present
complications for vision—including myopia and irregular astigmatism—and surgical …
is an ectatic corneal disorder. Early diagnosis is crucial, as keratoconus can present
complications for vision—including myopia and irregular astigmatism—and surgical …
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Keratoconus in hereditary spastic paraplegia 15 and Kjellin syndrome: a case report
G Dimitrova, D Ristikj Stomnaroska, F Gilevska… - Ophthalmic Genetics, 2025… We report on a patient diagnosed with HSP15 and Kjellin syndrome who
developed keratoconus during ophthalmic follow-up. Keratoconus has been
reported in patients with HSP11 (Citation11), but to our knowledge, this is the first …
G Dimitrova, D Ristikj Stomnaroska, F Gilevska… - Ophthalmic Genetics, 2025
… We report on a patient diagnosed with HSP15 and Kjellin syndrome who
developed keratoconus during ophthalmic follow-up. Keratoconus has been
reported in patients with HSP11 (Citation11), but to our knowledge, this is the first …
developed keratoconus during ophthalmic follow-up. Keratoconus has been
reported in patients with HSP11 (Citation11), but to our knowledge, this is the first …
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Keratoconus in hereditary spastic paraplegia 15 and Kjellin syndrome: a case report
G Dimitrova, D Ristikj Stomnaroska, F Gilevska… - Ophthalmic Genetics, 2025… We report on a patient diagnosed with HSP15 and Kjellin syndrome who
developed keratoconus during ophthalmic follow-up. Keratoconus has been
reported in patients with HSP11 (Citation11), but to our knowledge, this is the first …
G Dimitrova, D Ristikj Stomnaroska, F Gilevska… - Ophthalmic Genetics, 2025
… We report on a patient diagnosed with HSP15 and Kjellin syndrome who
developed keratoconus during ophthalmic follow-up. Keratoconus has been
reported in patients with HSP11 (Citation11), but to our knowledge, this is the first …
developed keratoconus during ophthalmic follow-up. Keratoconus has been
reported in patients with HSP11 (Citation11), but to our knowledge, this is the first …
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[PDF] Increased risk of keratoconus in patients with atopic dermatitis: a race and sex-stratified large-scale analysis from an international database
RKI BS, HAP BS, HM Retif, LM MD, CTL MD, JMJ MD… - 2025… race/ethnicity, keratoconus risk ratios … keratoconus. Our results support prior
smaller-scale studies. A nationwide Danish registry-based observational study of
5766 adults with mild AD and 4272 with severe AD found a significant, severitydependent …
RKI BS, HAP BS, HM Retif, LM MD, CTL MD, JMJ MD… - 2025
… race/ethnicity, keratoconus risk ratios … keratoconus. Our results support prior
smaller-scale studies. A nationwide Danish registry-based observational study of
5766 adults with mild AD and 4272 with severe AD found a significant, severitydependent …
smaller-scale studies. A nationwide Danish registry-based observational study of
5766 adults with mild AD and 4272 with severe AD found a significant, severitydependent …
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Mediation role of corneal biomechanical and topographic parameters in eye rubbing and keratoconus based on the Chinese keratoconus (CKC) cohort study
K Yang, R Tu, L Xu, Y Gu, Q Fan, S Yin, Y Yuan… - Frontiers in Bioengineering and …Several studies have shown that eye rubbing is associated with an increased risk of
keratoconus (KC).However, the potential mediating roles between eye rubbing and
KC remain largely unknown. Thus, this study aimed to explore the mediating roles of …
K Yang, R Tu, L Xu, Y Gu, Q Fan, S Yin, Y Yuan… - Frontiers in Bioengineering and …
Several studies have shown that eye rubbing is associated with an increased risk of
keratoconus (KC).However, the potential mediating roles between eye rubbing and
KC remain largely unknown. Thus, this study aimed to explore the mediating roles of …
keratoconus (KC).However, the potential mediating roles between eye rubbing and
KC remain largely unknown. Thus, this study aimed to explore the mediating roles of …
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[HTML] Simultaneous versus sequential corneal cross-linking and intracorneal ring segments implantation for keratoconus: two-year study
I Omar, RS Elhiny - International Journal of Ophthalmology, 2025AIM To compare simultaneous corneal collagen cross-linking (CXL) with
intracorneal ring segment (ICRS) implantation versus successive ICRS followed by
CXL and detect the impact of the timing of CXL after ICRS implantation in the …
I Omar, RS Elhiny - International Journal of Ophthalmology, 2025
AIM To compare simultaneous corneal collagen cross-linking (CXL) with
intracorneal ring segment (ICRS) implantation versus successive ICRS followed by
CXL and detect the impact of the timing of CXL after ICRS implantation in the …
intracorneal ring segment (ICRS) implantation versus successive ICRS followed by
CXL and detect the impact of the timing of CXL after ICRS implantation in the …
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Correlations between Tear Lymphocytotoxin-a (LT-α) Level and Disease Severity in Adult Keratoconus
X Qin, S Luo, X Fang, X Xiao, Z Xie, X Shang, XI LAN… - Frontiers in Medicine… To investigate the tear lymphocytotoxin-α (LT-α) levels in adult keratoconus
patients and identify the correlations between LT-α and the … disease severity of
keratoconus, implying that immune-related factors might be involved in the …
X Qin, S Luo, X Fang, X Xiao, Z Xie, X Shang, XI LAN… - Frontiers in Medicine
… To investigate the tear lymphocytotoxin-α (LT-α) levels in adult keratoconus
patients and identify the correlations between LT-α and the … disease severity of
keratoconus, implying that immune-related factors might be involved in the …
patients and identify the correlations between LT-α and the … disease severity of
keratoconus, implying that immune-related factors might be involved in the …
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[HTML] Simultaneous versus sequential corneal cross-linking and intracorneal ring segments implantation for keratoconus: two-year study
I Omar, RS Elhiny - International Journal of Ophthalmology, 2025AIM To compare simultaneous corneal collagen cross-linking (CXL) with
intracorneal ring segment (ICRS) implantation versus successive ICRS followed by
CXL and detect the impact of the timing of CXL after ICRS implantation in the …
I Omar, RS Elhiny - International Journal of Ophthalmology, 2025
AIM To compare simultaneous corneal collagen cross-linking (CXL) with
intracorneal ring segment (ICRS) implantation versus successive ICRS followed by
CXL and detect the impact of the timing of CXL after ICRS implantation in the …
intracorneal ring segment (ICRS) implantation versus successive ICRS followed by
CXL and detect the impact of the timing of CXL after ICRS implantation in the …
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Correlations between Tear Lymphocytotoxin-a (LT-α) Level and Disease Severity in Adult Keratoconus
X Qin, S Luo, X Fang, X Xiao, Z Xie, X Shang, XI LAN… - Frontiers in Medicine… To investigate the tear lymphocytotoxin-α (LT-α) levels in adult keratoconus
patients and identify the correlations between LT-α and the … disease severity of
keratoconus, implying that immune-related factors might be involved in the …
X Qin, S Luo, X Fang, X Xiao, Z Xie, X Shang, XI LAN… - Frontiers in Medicine
… To investigate the tear lymphocytotoxin-α (LT-α) levels in adult keratoconus
patients and identify the correlations between LT-α and the … disease severity of
keratoconus, implying that immune-related factors might be involved in the …
patients and identify the correlations between LT-α and the … disease severity of
keratoconus, implying that immune-related factors might be involved in the …
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Genetic and immune landscape of keratoconus: insights from Mendelian randomization analysis
Y Yu, Q Liu, C Zhou, J Jiang, Y Li - Mammalian Genome, 2025This study aimed to identify key genes and immune features associated with
keratoconus (KC), a progressive eye disorder, by integrating genomic and
transcriptomic data using Mendelian randomization (MR) methods. We employed …
Y Yu, Q Liu, C Zhou, J Jiang, Y Li - Mammalian Genome, 2025
This study aimed to identify key genes and immune features associated with
keratoconus (KC), a progressive eye disorder, by integrating genomic and
transcriptomic data using Mendelian randomization (MR) methods. We employed …
keratoconus (KC), a progressive eye disorder, by integrating genomic and
transcriptomic data using Mendelian randomization (MR) methods. We employed …
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An Update on Surgical Treatments of Keratoconus
J Ellis, A Verkade - Advances in Ophthalmology and Optometry, 2025… , and a positive family history of keratoconus [1]. Many patients with mild to
advanced keratoconus can be fit with rigid contact lenses. Though even with
improvements in contact lens technology, approximately 15% of keratoconus …
J Ellis, A Verkade - Advances in Ophthalmology and Optometry, 2025
… , and a positive family history of keratoconus [1]. Many patients with mild to
advanced keratoconus can be fit with rigid contact lenses. Though even with
improvements in contact lens technology, approximately 15% of keratoconus …
advanced keratoconus can be fit with rigid contact lenses. Though even with
improvements in contact lens technology, approximately 15% of keratoconus …
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[HTML] Deciphering mitochondrial dysfunction in keratoconus: Insights into ACSL4 from machine learning-based bulk and single-cell transcriptome analyses and …
Y Cai, T Zhou, X Cai, W Shi, H Sun, Y Fu - Computational and Structural …, 2025Keratoconus (KC) is a prevalent ectatic corneal disease and the leading cause of
corneal transplantation globally. Despite evidence of mitochondrial abnormalities in
KC, the underlying mechanisms remain unclear. Our aim was to investigate the role …
Y Cai, T Zhou, X Cai, W Shi, H Sun, Y Fu - Computational and Structural …, 2025
Keratoconus (KC) is a prevalent ectatic corneal disease and the leading cause of
corneal transplantation globally. Despite evidence of mitochondrial abnormalities in
KC, the underlying mechanisms remain unclear. Our aim was to investigate the role …
corneal transplantation globally. Despite evidence of mitochondrial abnormalities in
KC, the underlying mechanisms remain unclear. Our aim was to investigate the role …
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[PDF] Public awareness of keratoconus and its association with eye rubbing behavior: a population-based study in Jazan, Saudi Arabia
RA Jahlan, AA Daghreeri, AA Otaif, AA Otaif…Background Keratoconus (KC) was first described in 1854 by Nottingham and is a
degenerative, bilateral, progressive condition characterized by ectasia, thinness,
and increased curvature of the cornea, it is also associated with the loss of visual …
RA Jahlan, AA Daghreeri, AA Otaif, AA Otaif…
Background Keratoconus (KC) was first described in 1854 by Nottingham and is a
degenerative, bilateral, progressive condition characterized by ectasia, thinness,
and increased curvature of the cornea, it is also associated with the loss of visual …
degenerative, bilateral, progressive condition characterized by ectasia, thinness,
and increased curvature of the cornea, it is also associated with the loss of visual …
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[PDF] A portable diagnosis model for Keratoconus using a smartphone
Y Li, M Kim, Y Jin, P Ho, JW Chong - arXiv preprint arXiv:2505.08616, 2025Keratoconus (KC) is a progressive corneal disorder characterized by localized
thinning and protrusion, leading to visual distortion. While Placido disc-based
topography remains a standard in clinical diagnostics, its dependence on …
Y Li, M Kim, Y Jin, P Ho, JW Chong - arXiv preprint arXiv:2505.08616, 2025
Keratoconus (KC) is a progressive corneal disorder characterized by localized
thinning and protrusion, leading to visual distortion. While Placido disc-based
topography remains a standard in clinical diagnostics, its dependence on …
thinning and protrusion, leading to visual distortion. While Placido disc-based
topography remains a standard in clinical diagnostics, its dependence on …
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[PDF] A ring selection platform for treatment of keratoconus
A Khademi, M Asghari, MR Naderi Eshkaftaki - Sharif Journal of Mechanical …, 2025Keratoconus is an eye disease in which the cornea thins and, due to intraocular
pressure, … a specific patient with unique characteristics of keratoconus, creating a
platform based on data … solution to improve treatment planning for keratoconus …
A Khademi, M Asghari, MR Naderi Eshkaftaki - Sharif Journal of Mechanical …, 2025
Keratoconus is an eye disease in which the cornea thins and, due to intraocular
pressure, … a specific patient with unique characteristics of keratoconus, creating a
platform based on data … solution to improve treatment planning for keratoconus …
pressure, … a specific patient with unique characteristics of keratoconus, creating a
platform based on data … solution to improve treatment planning for keratoconus …
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[HTML] Early diagnosis of keratoconus using corneal biomechanics and OCT derived technologies
X Wang, S Maeno, Y Wang, S Koh, S Chen… - Eye and Vision, 2025Early detection of keratoconus is essential for maximizing the potential of cross-linking
treatments designed to halt keratoconus progression, minimizing the risks of
iatrogenic ectasia as well as reducing the need for corneal transplantation. This …
X Wang, S Maeno, Y Wang, S Koh, S Chen… - Eye and Vision, 2025
Early detection of keratoconus is essential for maximizing the potential of cross-linking
treatments designed to halt keratoconus progression, minimizing the risks of
iatrogenic ectasia as well as reducing the need for corneal transplantation. This …
treatments designed to halt keratoconus progression, minimizing the risks of
iatrogenic ectasia as well as reducing the need for corneal transplantation. This …
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Evaluation of Corneal Structural Changes and Visual Acuity Improvement in Keratoconus Patients Following Corneal Cross-Linking (CXL) and Photorefractive …
A Attar, S Bamdad, N Fazlinejad, A Sheida… - 2025Purpose: Keratoconus is a progressive, non-inflammatory corneal disease with
thinning and protrusion, and vision distortion. The present study addresses the
structural change of the cornea and visual acuity improvement in keratoconus …
A Attar, S Bamdad, N Fazlinejad, A Sheida… - 2025
Purpose: Keratoconus is a progressive, non-inflammatory corneal disease with
thinning and protrusion, and vision distortion. The present study addresses the
structural change of the cornea and visual acuity improvement in keratoconus …
thinning and protrusion, and vision distortion. The present study addresses the
structural change of the cornea and visual acuity improvement in keratoconus …
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… of Corneal Aberrometric Measurements With a New Hybrid Device and Comparison With a Scheimpflug/Placido Topography in Different Grades of Keratoconus
R Ning, Y Yang, H Xu, K Li, Z Li, Y Li, G Savini… - Journal of Refractive …, 2025… This prospective study included 99 eyes of 99 patients with keratoconus.
Regarding intraobserver repeatability, all S w values were 0.16 … to improve with
increasing keratoconus stage. All parameters showed a narrow 95% LoA and varied …
R Ning, Y Yang, H Xu, K Li, Z Li, Y Li, G Savini… - Journal of Refractive …, 2025
… This prospective study included 99 eyes of 99 patients with keratoconus.
Regarding intraobserver repeatability, all S w values were 0.16 … to improve with
increasing keratoconus stage. All parameters showed a narrow 95% LoA and varied …
Regarding intraobserver repeatability, all S w values were 0.16 … to improve with
increasing keratoconus stage. All parameters showed a narrow 95% LoA and varied …
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… -off Corneal Cross-linking With Preservation of a Central Epithelial Island in the Management of Paracentral Progressive Keratoconus: A Comparative Clinical Trial
AS Khalil, MAM Khedr, AAM Gad, AG Ali - Journal of Refractive Surgery, 2025… The steepest point may affect the central 3-mm zone (central keratoconus) or
located between 3 and 5 mm of the corneal center (paracentral keratoconus).Corneal
cross-linking (CXL) using riboflavin and ultraviolet-A (UV-A) has proved its efficacy …
AS Khalil, MAM Khedr, AAM Gad, AG Ali - Journal of Refractive Surgery, 2025
… The steepest point may affect the central 3-mm zone (central keratoconus) or
located between 3 and 5 mm of the corneal center (paracentral keratoconus).Corneal
cross-linking (CXL) using riboflavin and ultraviolet-A (UV-A) has proved its efficacy …
located between 3 and 5 mm of the corneal center (paracentral keratoconus).Corneal
cross-linking (CXL) using riboflavin and ultraviolet-A (UV-A) has proved its efficacy …
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[PDF] Evaluation of Keratoconus Prevalence Among College-Aged Students at a Large University Setting
M Roth - 2025… the prevalence of keratoconus within the target population, as well as investigate
a possible prevalence rate for keratoconus suspects. A secondary objective of this
study is to explore if topographic indices other than those typically used to identify …
M Roth - 2025
… the prevalence of keratoconus within the target population, as well as investigate
a possible prevalence rate for keratoconus suspects. A secondary objective of this
study is to explore if topographic indices other than those typically used to identify …
a possible prevalence rate for keratoconus suspects. A secondary objective of this
study is to explore if topographic indices other than those typically used to identify …
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[PDF] Corneal Endothelium Specular Microscopic Changes in Different Protocols of Collagen Cross Linking in Keratoconus
AAE El-Hayes, SMH Soliman, MK Abo-elnour… - Ain Shams Medical Journal, 2025Background: Corneal cross-linking is the most used strategy to treat keratoconus, …
keratoconus cases, as a comparison of the Accelerated Protocol and the Standard
Dresden Protocol.Patients and Methods: This study is a prospective study …
AAE El-Hayes, SMH Soliman, MK Abo-elnour… - Ain Shams Medical Journal, 2025
Background: Corneal cross-linking is the most used strategy to treat keratoconus, …
keratoconus cases, as a comparison of the Accelerated Protocol and the Standard
Dresden Protocol.Patients and Methods: This study is a prospective study …
keratoconus cases, as a comparison of the Accelerated Protocol and the Standard
Dresden Protocol.Patients and Methods: This study is a prospective study …
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Astigmatic vector analysis after combined surgery for forme fruste keratoconus
A Sağlık, A Şimşek - International Ophthalmology, 2025… A total of 27 eyes in 20 patients (8 men and 12 women) with forme fruste
keratoconus who … 20/25 (Snellen fraction), and fruste keratoconus formation; clear
central cornea with thinnest … keratoconus (without a slightly asymmetric bow tie or …
A Sağlık, A Şimşek - International Ophthalmology, 2025
… A total of 27 eyes in 20 patients (8 men and 12 women) with forme fruste
keratoconus who … 20/25 (Snellen fraction), and fruste keratoconus formation; clear
central cornea with thinnest … keratoconus (without a slightly asymmetric bow tie or …
keratoconus who … 20/25 (Snellen fraction), and fruste keratoconus formation; clear
central cornea with thinnest … keratoconus (without a slightly asymmetric bow tie or …
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[PDF] Intracorneal ring segment implantation for eyes with keratoconus and corneas thinner than 400 microns
HM Abdelhameed, ASA Obaia, AF Elgazzar… - … hypothesis discovery and …, 2025Background: Intracorneal ring segment (ICRS) implantation is a promising and
effective treatment option for keratoconus. However, a corneal thickness of less than
400 microns presents a unique challenge. This study assessed the clinical course …
HM Abdelhameed, ASA Obaia, AF Elgazzar… - … hypothesis discovery and …, 2025
Background: Intracorneal ring segment (ICRS) implantation is a promising and
effective treatment option for keratoconus. However, a corneal thickness of less than
400 microns presents a unique challenge. This study assessed the clinical course …
effective treatment option for keratoconus. However, a corneal thickness of less than
400 microns presents a unique challenge. This study assessed the clinical course …
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[PDF] KERATOCONUS DETECTION USING DEEP LEARNING
YM Abbosh, SM Ali, DM Ali, IA Alhummada… Through DL, it is possible to identify precise signs of keratoconus at an early stage,
which is crucial for timely intervention and … keratoconus detection tools globally,
thus improving access to high-quality eye care and reducing the prevalence of …
YM Abbosh, SM Ali, DM Ali, IA Alhummada
… Through DL, it is possible to identify precise signs of keratoconus at an early stage,
which is crucial for timely intervention and … keratoconus detection tools globally,
thus improving access to high-quality eye care and reducing the prevalence of …
which is crucial for timely intervention and … keratoconus detection tools globally,
thus improving access to high-quality eye care and reducing the prevalence of …
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… safety of accelerated trans-epithelial iontophoretic corneal collagen cross-linking (accelerated i-CXL-TE) in young patients with progressive keratoconus: 9-year follow …
M Troisi, S Troisi, C Costagliola, V Romano - 2025Purpose To evaluate the long-term efficacy and safety of Accelerated i-CXL-TE in
paediatric and young adult patients with progressive keratoconus (pKC), reporting
clinical outcomes and side effects over a 9-year follow-up.Methods Sixty-nine eyes …
M Troisi, S Troisi, C Costagliola, V Romano - 2025
Purpose To evaluate the long-term efficacy and safety of Accelerated i-CXL-TE in
paediatric and young adult patients with progressive keratoconus (pKC), reporting
clinical outcomes and side effects over a 9-year follow-up.Methods Sixty-nine eyes …
paediatric and young adult patients with progressive keratoconus (pKC), reporting
clinical outcomes and side effects over a 9-year follow-up.Methods Sixty-nine eyes …
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Genetic predictors in keratoconus etiology (literature review)
SB Izmailova, AZ Tsyganov, LT Astoyan, RA Zinchenko…Keratoconus is a multifactorial degenerative disease including genetic etiology
related to corneal ectasia. While diagnostic methods are updated, the condition
incidence has increased to 1 per 100 patients, and it is increasing annually …
SB Izmailova, AZ Tsyganov, LT Astoyan, RA Zinchenko…
Keratoconus is a multifactorial degenerative disease including genetic etiology
related to corneal ectasia. While diagnostic methods are updated, the condition
incidence has increased to 1 per 100 patients, and it is increasing annually …
related to corneal ectasia. While diagnostic methods are updated, the condition
incidence has increased to 1 per 100 patients, and it is increasing annually …
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[HTML] Corneal necrosis following an epithelium-off accelerated cross-linking for keratoconus, a case report and literature review
Y Bennani, S Benamar, S Bencherif, M Belmekki… - Indian Journal of …, 2025… A 22-year-old male patient with a medical record of advanced bilateral
keratoconus … Collagen cross-linking (CXL) is a technique designed to stop the
progression of keratoconus (KC) … report a case of corneal melting and necrosis 2 …
Y Bennani, S Benamar, S Bencherif, M Belmekki… - Indian Journal of …, 2025
… A 22-year-old male patient with a medical record of advanced bilateral
keratoconus … Collagen cross-linking (CXL) is a technique designed to stop the
progression of keratoconus (KC) … report a case of corneal melting and necrosis 2 …
keratoconus … Collagen cross-linking (CXL) is a technique designed to stop the
progression of keratoconus (KC) … report a case of corneal melting and necrosis 2 …
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[HTML] Comparative study of the corneal morphological characteristics of keratoconus evaluated using Pentacam, Sirius, and CASIA2
B Sun, X Hu, X Peng, W Ten, Y Huang, L Sun, X Zhou… - … and Photodynamic Therapy, 2025… at thinnest points measured using Sirius were the highest in keratoconus group
and the lowest in control group. Corneal refractive power … ), fKm, and pKm were
lower and narrower than in keratoconus. In keratoconus group, Pentacam and …
B Sun, X Hu, X Peng, W Ten, Y Huang, L Sun, X Zhou… - … and Photodynamic Therapy, 2025
… at thinnest points measured using Sirius were the highest in keratoconus group
and the lowest in control group. Corneal refractive power … ), fKm, and pKm were
lower and narrower than in keratoconus. In keratoconus group, Pentacam and …
and the lowest in control group. Corneal refractive power … ), fKm, and pKm were
lower and narrower than in keratoconus. In keratoconus group, Pentacam and …
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[HTML] Scleral Thickness in Eyes with Pachychoroid Pigment Epitheliopathy accompanied by Keratoconus
P Forte, A Feo, H Koizumi, E Borrelli, R Manocchio… - Ophthalmology Science, 2025Scleral Thickness in Eyes with Pachychoroid Pigment Epitheliopathy accompanied
by Keratoconus - ScienceDirect …
P Forte, A Feo, H Koizumi, E Borrelli, R Manocchio… - Ophthalmology Science, 2025
Scleral Thickness in Eyes with Pachychoroid Pigment Epitheliopathy accompanied
by Keratoconus - ScienceDirect …
by Keratoconus - ScienceDirect …
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Minimally invasive approaches to management of keratoconus
RB Singh, V Jhanji - Current Opinion in Ophthalmology… Keratoconus is one of the leading indications for corneal transplantation surgery.
Although the surgical success rate is high, the long-term outcomes do not match
other solid organ transplantation procedures. The availability of minimally invasive …
RB Singh, V Jhanji - Current Opinion in Ophthalmology
… Keratoconus is one of the leading indications for corneal transplantation surgery.
Although the surgical success rate is high, the long-term outcomes do not match
other solid organ transplantation procedures. The availability of minimally invasive …
Although the surgical success rate is high, the long-term outcomes do not match
other solid organ transplantation procedures. The availability of minimally invasive …
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Concentric Intrastromal Corneal Ring Implantation for Asymmetric Keratoconus: A Case Series
J Sandes, P Ferrara, BK Moscovici - International Journal of Keratoconus and Ectatic …, 2025… keratoconus who experienced unsatisfactory results from previous protocols.
Materials and methods: This case series included 3 patients with asymmetric
keratoconus … A 36-year-old male (case 2) with enantiomorphic keratoconus …
J Sandes, P Ferrara, BK Moscovici - International Journal of Keratoconus and Ectatic …, 2025
… keratoconus who experienced unsatisfactory results from previous protocols.
Materials and methods: This case series included 3 patients with asymmetric
keratoconus … A 36-year-old male (case 2) with enantiomorphic keratoconus …
Materials and methods: This case series included 3 patients with asymmetric
keratoconus … A 36-year-old male (case 2) with enantiomorphic keratoconus …
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[HTML] Bilateral simultaneous accelerated corneal collagen cross-linking in pediatric keratoconus: 24-month follow-up results
D Virdi, S Gupta, S Tomar, TS Ahluwalia - Indian Journal of Ophthalmology, 2025… Data from 78 eyes of 39 patients with bilateral progressive pediatric keratoconus
from 2018 to 2022 were included in this study. The mean age of the patients was
15.2 ± 1.8 years (range: 11 to 18 years). A total of 27 patients (69.2%) were males …
D Virdi, S Gupta, S Tomar, TS Ahluwalia - Indian Journal of Ophthalmology, 2025
… Data from 78 eyes of 39 patients with bilateral progressive pediatric keratoconus
from 2018 to 2022 were included in this study. The mean age of the patients was
15.2 ± 1.8 years (range: 11 to 18 years). A total of 27 patients (69.2%) were males …
from 2018 to 2022 were included in this study. The mean age of the patients was
15.2 ± 1.8 years (range: 11 to 18 years). A total of 27 patients (69.2%) were males …
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Changes in retinal and choroidal thickness and blood density in participants with keratoconus
B Sun, Y Xian, D Yang, X Hu, J Wang, L Sun, Y Shen… - … optics: the journal of the British …… in participants with keratoconus. … keratoconus choroidal/retinal parameters and
ABCD grading or tomographic keratoconus classification (TKC) staging were
assessed. Multivariable linear regression models were used to investigate the …
B Sun, Y Xian, D Yang, X Hu, J Wang, L Sun, Y Shen… - … optics: the journal of the British …
… in participants with keratoconus. … keratoconus choroidal/retinal parameters and
ABCD grading or tomographic keratoconus classification (TKC) staging were
assessed. Multivariable linear regression models were used to investigate the …
ABCD grading or tomographic keratoconus classification (TKC) staging were
assessed. Multivariable linear regression models were used to investigate the …
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[HTML] Bilateral Keratoconus in Diffuse Cutaneous Systemic Sclerosis: A Rare Presentation-Is There Any Role of Autoimmunity?
S Sadhu, B Srinivasan, M Lakshmipathy… - Turk J Ophthalmol, 2025Keratoconus (KC) has long been defined as a non-inflammatory disease of the
cornea. However, recent evidence increasingly suggests the possibility of an
underlying subclinical inflammation that may contribute to KC pathogenesis. 1, 2 …
S Sadhu, B Srinivasan, M Lakshmipathy… - Turk J Ophthalmol, 2025
Keratoconus (KC) has long been defined as a non-inflammatory disease of the
cornea. However, recent evidence increasingly suggests the possibility of an
underlying subclinical inflammation that may contribute to KC pathogenesis. 1, 2 …
cornea. However, recent evidence increasingly suggests the possibility of an
underlying subclinical inflammation that may contribute to KC pathogenesis. 1, 2 …
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Results Of Deep Anterıor Lamellar Keratoplasty (Dalk) In Keratoconus: A Retrospectıve Analysıs
M Yıldırım, S Keles, I Koçer - Van Medical Journal… INTRODUCTION: DALK is a surgical treatment used for many stromal pathologies
such as keratoconus, corneal scars, stromal dystrophy and stromal degeneration
that do not affect the endothelium The aim of this study was to present the clinical …
M Yıldırım, S Keles, I Koçer - Van Medical Journal
… INTRODUCTION: DALK is a surgical treatment used for many stromal pathologies
such as keratoconus, corneal scars, stromal dystrophy and stromal degeneration
that do not affect the endothelium The aim of this study was to present the clinical …
such as keratoconus, corneal scars, stromal dystrophy and stromal degeneration
that do not affect the endothelium The aim of this study was to present the clinical …
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[PDF] KERATOCONUS TREATMENT WITH CORNEAL COLLAGEN CROSSLINKING
I Ismaili, S Gazepov - KNOWLEDGE-International Journal, 2025… Тhis method is used to prevent the progression of corneal ectasia in keratoconus,
aiming to prevent progressive vision loss and avoid … in patients with keratoconus
were evaluated one year after the intervention. The study included 45 patients with …
I Ismaili, S Gazepov - KNOWLEDGE-International Journal, 2025
… Тhis method is used to prevent the progression of corneal ectasia in keratoconus,
aiming to prevent progressive vision loss and avoid … in patients with keratoconus
were evaluated one year after the intervention. The study included 45 patients with …
aiming to prevent progressive vision loss and avoid … in patients with keratoconus
were evaluated one year after the intervention. The study included 45 patients with …
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[PDF] Results of Deep Anterior Lamellar Keratoplasty (DALK) in Keratoconus: A Retrospective Analysis
M Yildirim, S Keleş, I Koçer… Introduction: DALK is a surgical treatment used for many stromal pathologies
such as keratoconus, corneal scars, stromal dystrophy and stromal degeneration
that do not affect the endothelium The aim of this study was to present the clinical …
M Yildirim, S Keleş, I Koçer
… Introduction: DALK is a surgical treatment used for many stromal pathologies
such as keratoconus, corneal scars, stromal dystrophy and stromal degeneration
that do not affect the endothelium The aim of this study was to present the clinical …
such as keratoconus, corneal scars, stromal dystrophy and stromal degeneration
that do not affect the endothelium The aim of this study was to present the clinical …
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Identification of risk factors for persistent corneal edema associated with acute corneal hydrops in keratoconus
T Aichi, K Kitazawa, R Kozaki, Y Yamashita, M Itoi… - Japanese Journal of …, 2025… The aim of this study was to investigate the clinical characteristics of acute
corneal hydrops (ACH) in patients with keratoconus and to examine the risk factors
for persistent corneal edema. … The purpose of this study was to clarify the clinical …
T Aichi, K Kitazawa, R Kozaki, Y Yamashita, M Itoi… - Japanese Journal of …, 2025
… The aim of this study was to investigate the clinical characteristics of acute
corneal hydrops (ACH) in patients with keratoconus and to examine the risk factors
for persistent corneal edema. … The purpose of this study was to clarify the clinical …
corneal hydrops (ACH) in patients with keratoconus and to examine the risk factors
for persistent corneal edema. … The purpose of this study was to clarify the clinical …
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[HTML] Advancements in the management of Keratoconus
A Harid… for keratoconus (2). This review aims to evaluate research advancements in new
corneal cross-linking techniques to manage keratoconus compared to traditional
methods of CXL with UVA/riboflavin in terms of halting the progression of …
A Harid
… for keratoconus (2). This review aims to evaluate research advancements in new
corneal cross-linking techniques to manage keratoconus compared to traditional
methods of CXL with UVA/riboflavin in terms of halting the progression of …
corneal cross-linking techniques to manage keratoconus compared to traditional
methods of CXL with UVA/riboflavin in terms of halting the progression of …
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Corneal Biomechanical Property Changes Following Corneal Collagen Cross-linking in Keratoconus: A Systematic Review and Meta-regression Analysis
L Krungkraipetch, A Assawaboonyadech… - 2025… cross-linking (CXL) treatment for keratoconus. The flow diagram shows a rigorous …
in keratoconus patients (Fig. 1). This systematic review; 11 studies spanning 2009–2024,
corneal collagen cross-linking appears to effectively improve biomechanical …
L Krungkraipetch, A Assawaboonyadech… - 2025
… cross-linking (CXL) treatment for keratoconus. The flow diagram shows a rigorous …
in keratoconus patients (Fig. 1). This systematic review; 11 studies spanning 2009–2024,
corneal collagen cross-linking appears to effectively improve biomechanical …
in keratoconus patients (Fig. 1). This systematic review; 11 studies spanning 2009–2024,
corneal collagen cross-linking appears to effectively improve biomechanical …
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[HTML] A Novel Approach to Fabricate Early Keratoconus Phantom Models
H Tong, M Wu, J Han, L Li, H Zhang - Translational Vision Science & Technology, 2025… The paracentral keratoconus shows greater stiffness than the central keratoconus,
which is consistent with our results. Such findings indicate that the paracentral
keratoconus is less likely to be detected than the central keratoconus, which may …
H Tong, M Wu, J Han, L Li, H Zhang - Translational Vision Science & Technology, 2025
… The paracentral keratoconus shows greater stiffness than the central keratoconus,
which is consistent with our results. Such findings indicate that the paracentral
keratoconus is less likely to be detected than the central keratoconus, which may …
which is consistent with our results. Such findings indicate that the paracentral
keratoconus is less likely to be detected than the central keratoconus, which may …
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[HTML] Studying the effect of keratoconus severity on the accuracy of intraocular lens power calculation using newer keratoconus-specific formulas
HA Helaly, TM Ibrahim, MS Hassan, MS El-Mansy - BMC ophthalmology, 2025Purpose to study the effect of keratoconus severity on the accuracy of intraocular
lens power calculation using newer keratoconus (KC) specific formulas. Methods
This was a retrospective case series that included 99 eyes from 99 patients. The …
HA Helaly, TM Ibrahim, MS Hassan, MS El-Mansy - BMC ophthalmology, 2025
Purpose to study the effect of keratoconus severity on the accuracy of intraocular
lens power calculation using newer keratoconus (KC) specific formulas. Methods
This was a retrospective case series that included 99 eyes from 99 patients. The …
lens power calculation using newer keratoconus (KC) specific formulas. Methods
This was a retrospective case series that included 99 eyes from 99 patients. The …
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[HTML] Corneal crosslinking effects on macular microvasculature in progressive keratoconus cases: A prospective single-arm study
A Tarkavani, SA Nikmanesh, P Ghodraty, A Arasteh - … and Photodynamic Therapy, 2025Objective To evaluate the macular microvascular changes after corneal collagen
crosslinking (CXL) in progressive keratoconus (KCN) cases Design Single-arm
prospective interventional study Participants Thirty eyes of 25 cases with …
A Tarkavani, SA Nikmanesh, P Ghodraty, A Arasteh - … and Photodynamic Therapy, 2025
Objective To evaluate the macular microvascular changes after corneal collagen
crosslinking (CXL) in progressive keratoconus (KCN) cases Design Single-arm
prospective interventional study Participants Thirty eyes of 25 cases with …
crosslinking (CXL) in progressive keratoconus (KCN) cases Design Single-arm
prospective interventional study Participants Thirty eyes of 25 cases with …
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[PDF] Safety and efficacy of simultaneous photorefractive keratectomy and corneal cross-linking in managing suspected keratoconus
A Dal, M Canleblebici, M Erdağ - Indian Journal of Ophthalmology, 2025… with suspected keratoconus who underwent simultaneous PRK + CXL with those
of patients without keratoconus suspicion who underwent PRK alone. The purpose
was to evaluate the safety and efficacy of the combined PRK + CXL procedure for …
A Dal, M Canleblebici, M Erdağ - Indian Journal of Ophthalmology, 2025
… with suspected keratoconus who underwent simultaneous PRK + CXL with those
of patients without keratoconus suspicion who underwent PRK alone. The purpose
was to evaluate the safety and efficacy of the combined PRK + CXL procedure for …
of patients without keratoconus suspicion who underwent PRK alone. The purpose
was to evaluate the safety and efficacy of the combined PRK + CXL procedure for …
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[PDF] Evaluating the efficacy and safety of iontophoresis-assisted corneal cross-linking compared to standard CXL in the treatment of keratoconus
N Alqudah, A Alqudah, S Alshamarti, Z Shannak - Indian Journal of Ophthalmology, 2025… prevalence of keratoconus.[5,15] Our cohort showed a male predominance with
keratoconus; however, several studies showed no sex predisposition to keratoconus.
Altered … Keratoconus is frequently associated with substantial myopia; however …
N Alqudah, A Alqudah, S Alshamarti, Z Shannak - Indian Journal of Ophthalmology, 2025
… prevalence of keratoconus.[5,15] Our cohort showed a male predominance with
keratoconus; however, several studies showed no sex predisposition to keratoconus.
Altered … Keratoconus is frequently associated with substantial myopia; however …
keratoconus; however, several studies showed no sex predisposition to keratoconus.
Altered … Keratoconus is frequently associated with substantial myopia; however …
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[PDF] … laser-assisted corneal intrastromal negative meniscus lenticule implantation with accelerated collagen crosslinking (FILAC) in advanced keratoconus in Indian eyes …
R Sinha, S Anjum, K Gupta, T Agarwal, N Sharma… - Indian Journal of …, 2025… ) in advanced keratoconus. Methods: A prospective, interventional study
evaluated the outcomes of FILAC in eyes with progressive keratoconus of Amsler‑…
Conclusion: This technique effectively halts disease progression and improves …
R Sinha, S Anjum, K Gupta, T Agarwal, N Sharma… - Indian Journal of …, 2025
… ) in advanced keratoconus. Methods: A prospective, interventional study
evaluated the outcomes of FILAC in eyes with progressive keratoconus of Amsler‑…
Conclusion: This technique effectively halts disease progression and improves …
evaluated the outcomes of FILAC in eyes with progressive keratoconus of Amsler‑…
Conclusion: This technique effectively halts disease progression and improves …
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Developing a clinical guideline for private eye care practice for the management of keratoconus with scleral contact lenses
M Järvinen - 2025… pre-existing and valid clinical guidelines concentrating on both keratoconus
assessment and management, as well as scleral lens fitting … and manage
keratoconus patients with scleral lenses. Using the guideline, practitioners can …
M Järvinen - 2025
… pre-existing and valid clinical guidelines concentrating on both keratoconus
assessment and management, as well as scleral lens fitting … and manage
keratoconus patients with scleral lenses. Using the guideline, practitioners can …
assessment and management, as well as scleral lens fitting … and manage
keratoconus patients with scleral lenses. Using the guideline, practitioners can …
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[HTML] Corneal Tomographic Changes in Keratoconus Associated with Scleral Lens Wear: A Case-Control Analysis for 12-Month Follow-Up
WH Lin, TH Tsai, CH Hsiao, CC Sun, JS Lee, KK Lin - Medicina, 2025… in keratoconus patients through a case-controlled design. Materials and Methods:
This retrospective study included 220 keratoconus patients, … Therefore, this study
aims to evaluate the 12-month effects of scleral lens wear on corneal tomography in …
WH Lin, TH Tsai, CH Hsiao, CC Sun, JS Lee, KK Lin - Medicina, 2025
… in keratoconus patients through a case-controlled design. Materials and Methods:
This retrospective study included 220 keratoconus patients, … Therefore, this study
aims to evaluate the 12-month effects of scleral lens wear on corneal tomography in …
This retrospective study included 220 keratoconus patients, … Therefore, this study
aims to evaluate the 12-month effects of scleral lens wear on corneal tomography in …
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[HTML] Visual rehabilitation in keratoconus by altering corneal shape using the corneal crosslinking pen: initial results
AA Saks, C Saks, B Bert - Graefe's Archive for Clinical and Experimental …, 2025… The objective of the present study was to evaluate the 12 month safety and
effectiveness of the CCXL Pen in patients with keratoconus. … of the CCXL Pen in
patients diagnosed with progressive keratoconus. Keratoconus was diagnosed …
AA Saks, C Saks, B Bert - Graefe's Archive for Clinical and Experimental …, 2025
… The objective of the present study was to evaluate the 12 month safety and
effectiveness of the CCXL Pen in patients with keratoconus. … of the CCXL Pen in
patients diagnosed with progressive keratoconus. Keratoconus was diagnosed …
effectiveness of the CCXL Pen in patients with keratoconus. … of the CCXL Pen in
patients diagnosed with progressive keratoconus. Keratoconus was diagnosed …
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The effects of Vitamin D on Keratoconus progression
N Bartolomeo, M Pederzolli, S Palombella, P Fonteyne… - American Journal of …Purpose The aim of this study was to assess whether Vitamin D (Vit D)
supplementation affects local disease progression, as well as systemic inflammation,
collagen degradation, and oxidative stress in adolescents affected by Keratoconus (KC) …
N Bartolomeo, M Pederzolli, S Palombella, P Fonteyne… - American Journal of …
Purpose The aim of this study was to assess whether Vitamin D (Vit D)
supplementation affects local disease progression, as well as systemic inflammation,
collagen degradation, and oxidative stress in adolescents affected by Keratoconus (KC) …
supplementation affects local disease progression, as well as systemic inflammation,
collagen degradation, and oxidative stress in adolescents affected by Keratoconus (KC) …
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Treatment of keratoconus combined with adolescent vernal keratoconjunctivitis
Y Xiaofan, G Jinling - International Review of Ophthalmology, 2025… The treatment of ordinary keratoconus focuses more on mechanical correction (such
as … keratoconus are similar to those for ordinary keratoconus, which include early
keratoconus … -linking for preventing the progression of keratoconus, penetrating …
Y Xiaofan, G Jinling - International Review of Ophthalmology, 2025
… The treatment of ordinary keratoconus focuses more on mechanical correction (such
as … keratoconus are similar to those for ordinary keratoconus, which include early
keratoconus … -linking for preventing the progression of keratoconus, penetrating …
as … keratoconus are similar to those for ordinary keratoconus, which include early
keratoconus … -linking for preventing the progression of keratoconus, penetrating …
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[HTML] Differences between suspected keratoconus and subclinical keratoconus via multiparameter analysis in Chinese populations
Y Peng, Q Feng, T Shao, J Zhang, S Liu, H Wang, H Li… - Scientific Reports, 2025Keratoconus (KC) is a contraindication for corneal refractive surgery and can cause
serious damage to the patient's vision. To improve the safety of the surgery, we aim
to distinguish between suspected KC and subclinical KC, while also developing a …
Y Peng, Q Feng, T Shao, J Zhang, S Liu, H Wang, H Li… - Scientific Reports, 2025
Keratoconus (KC) is a contraindication for corneal refractive surgery and can cause
serious damage to the patient's vision. To improve the safety of the surgery, we aim
to distinguish between suspected KC and subclinical KC, while also developing a …
serious damage to the patient's vision. To improve the safety of the surgery, we aim
to distinguish between suspected KC and subclinical KC, while also developing a …
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[PDF] Waveform Score Influences the Outcome Metrics of the Ocular Response Analyzer in Patients with Keratoconus and in Healthy Controls
PT Yuhas, MM Fortman, M Nye, AM Mahmoud… - Current Eye Research, 2025… keratoconus cohort had diagnosed keratoconus (ICD-10 codes H18.60, H18.61,
or H18.62). Similar to participants in the control cohort, those in the keratoconus …
Exclusion criteria for the keratoconus cohort included glaucoma and other optic …
PT Yuhas, MM Fortman, M Nye, AM Mahmoud… - Current Eye Research, 2025
… keratoconus cohort had diagnosed keratoconus (ICD-10 codes H18.60, H18.61,
or H18.62). Similar to participants in the control cohort, those in the keratoconus …
Exclusion criteria for the keratoconus cohort included glaucoma and other optic …
or H18.62). Similar to participants in the control cohort, those in the keratoconus …
Exclusion criteria for the keratoconus cohort included glaucoma and other optic …
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[HTML] Causal Relationship Between Common Allergic Diseases and Keratoconus: A Two-Sample Mendelian Randomization Study
X Yang, X Yu, S Gao, P Wei, G Han - Translational Vision Science & Technology, 2025… The following flowchart illustrates the MR study of common allergic diseases and
keratoconus. The study postulates a potential causal link between common allergic
diseases and keratoconus, although there is currently no evidence to suggest a …
X Yang, X Yu, S Gao, P Wei, G Han - Translational Vision Science & Technology, 2025
… The following flowchart illustrates the MR study of common allergic diseases and
keratoconus. The study postulates a potential causal link between common allergic
diseases and keratoconus, although there is currently no evidence to suggest a …
keratoconus. The study postulates a potential causal link between common allergic
diseases and keratoconus, although there is currently no evidence to suggest a …
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Vision in times of war: Managing keratoconus in children and the role of omega-3 and vitamins in supporting eye health
V Tepleshniuk, Y Barinov - Contact Lens and Anterior Eye, 2025Study design This study was a prospective, observational cohort study designed to
evaluate the impact of Omega-3 fatty acid supplementation on corneal health in
pediatric patients with keratoconus. The study included two groups: a keratoconus …
V Tepleshniuk, Y Barinov - Contact Lens and Anterior Eye, 2025
Study design This study was a prospective, observational cohort study designed to
evaluate the impact of Omega-3 fatty acid supplementation on corneal health in
pediatric patients with keratoconus. The study included two groups: a keratoconus …
evaluate the impact of Omega-3 fatty acid supplementation on corneal health in
pediatric patients with keratoconus. The study included two groups: a keratoconus …
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[HTML] Repeatability of Scheimpflug Corneal Tomography in Patients with Keratoconus and Different Body Mass Indices
JS Lewis, L Angelo, A Gokul, CNJ McGhee, M Ziaei - Archives of Clinical …, 2025… Several studies have identified risk factors for keratoconus, including genetic
predisposition, environmental factors, and ocular rubbing [3]. … increased
prevalence of keratoconus in populations with higher rates of obesity [4]. In Aotearoa-New …
JS Lewis, L Angelo, A Gokul, CNJ McGhee, M Ziaei - Archives of Clinical …, 2025
… Several studies have identified risk factors for keratoconus, including genetic
predisposition, environmental factors, and ocular rubbing [3]. … increased
prevalence of keratoconus in populations with higher rates of obesity [4]. In Aotearoa-New …
predisposition, environmental factors, and ocular rubbing [3]. … increased
prevalence of keratoconus in populations with higher rates of obesity [4]. In Aotearoa-New …
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Is the Elimination of Keratoconus in Our Hands?
G Fickett, SA Naroo - Contact Lens and Anterior Eye, 2025… It is well established that keratoconus is associated with eye rubbing. The
literature is clear. For example, … of keratoconus to identify predictive factors. Their
univariate analysis found associations between keratoconus and atopy, eye rubbing …
G Fickett, SA Naroo - Contact Lens and Anterior Eye, 2025
… It is well established that keratoconus is associated with eye rubbing. The
literature is clear. For example, … of keratoconus to identify predictive factors. Their
univariate analysis found associations between keratoconus and atopy, eye rubbing …
literature is clear. For example, … of keratoconus to identify predictive factors. Their
univariate analysis found associations between keratoconus and atopy, eye rubbing …
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[HTML] Keratometry Changes Between Year Seven and Twelve After Corneal Crosslinking in Patients with Keratoconus
L Neuhann, D Vogel, J Dreyhaupt, A Kilani, C Enders - Journal of Clinical Medicine, 2025Background/Objectives: To evaluate the timing and extent to which late keratometric
changes can occur between year 7 and 12 after corneal collagen crosslinking (CXL)
in patients with keratoconus. Methods: A subgroup of a retrospective cohort study of …
L Neuhann, D Vogel, J Dreyhaupt, A Kilani, C Enders - Journal of Clinical Medicine, 2025
Background/Objectives: To evaluate the timing and extent to which late keratometric
changes can occur between year 7 and 12 after corneal collagen crosslinking (CXL)
in patients with keratoconus. Methods: A subgroup of a retrospective cohort study of …
changes can occur between year 7 and 12 after corneal collagen crosslinking (CXL)
in patients with keratoconus. Methods: A subgroup of a retrospective cohort study of …
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Using 3D Convolutional Neural Network and Corvis ST Corneal Dynamic Video for Detecting Forme Fruste Keratoconus
H Rong, G Liu, Y Wang, J Hu, Z Sun, N Gao, CS Kee… - Journal of Refractive …, 2025… However, due to the bilateral nature of the disease, it is likely that the fellow eye
will eventually progress to the clinical stage of keratoconus. Until then, the fellow eye
is considered to be forme fruste keratoconus (FFKC) or subclinical keratoconus.Subclinical …
H Rong, G Liu, Y Wang, J Hu, Z Sun, N Gao, CS Kee… - Journal of Refractive …, 2025
… However, due to the bilateral nature of the disease, it is likely that the fellow eye
will eventually progress to the clinical stage of keratoconus. Until then, the fellow eye
is considered to be forme fruste keratoconus (FFKC) or subclinical keratoconus.Subclinical …
will eventually progress to the clinical stage of keratoconus. Until then, the fellow eye
is considered to be forme fruste keratoconus (FFKC) or subclinical keratoconus.Subclinical …
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The Oxidative-Stress-Senescence Axis in Keratoconus: New Insights into Corneal Degeneration
ML Passaro, M Rinaldi, V Morgera, A Feola, V Romano… - Frontiers in Molecular Biosciences… of keratoconus, focusing on oxidative damage and inflammation. Senescence
emerges as a key driver of keratoconus pathogenesis. … common elements
enhances our understanding of the disease and paves the way for innovative …
ML Passaro, M Rinaldi, V Morgera, A Feola, V Romano… - Frontiers in Molecular Biosciences
… of keratoconus, focusing on oxidative damage and inflammation. Senescence
emerges as a key driver of keratoconus pathogenesis. … common elements
enhances our understanding of the disease and paves the way for innovative …
emerges as a key driver of keratoconus pathogenesis. … common elements
enhances our understanding of the disease and paves the way for innovative …
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Analysis of the clinical efficacy of high-ultraviolet energy epithelium-removing A-CXL in juvenile and adult keratoconus
XW Yin, W Chen, ZD Gong, Y Lu, XY Wu, D Wen - [Zhonghua yan ke za zhi] Chinese …, 2025Objective: To compare the 1-year clinical efficacy differences of high-ultraviolet
energy epithelium-removing accelerated corneal collagen cross-linking (A-CXL) in
the treatment of primary keratoconus in juveniles and adults. Methods: This is a …
XW Yin, W Chen, ZD Gong, Y Lu, XY Wu, D Wen - [Zhonghua yan ke za zhi] Chinese …, 2025
Objective: To compare the 1-year clinical efficacy differences of high-ultraviolet
energy epithelium-removing accelerated corneal collagen cross-linking (A-CXL) in
the treatment of primary keratoconus in juveniles and adults. Methods: This is a …
energy epithelium-removing accelerated corneal collagen cross-linking (A-CXL) in
the treatment of primary keratoconus in juveniles and adults. Methods: This is a …
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[PDF] Case Report: Recurrence of Keratoconus After Penetrating Keratoplasty
L Grybauskaite, R ZemaitieneKeratoconus (KC) is a progressive eye disease characterized by thinning and
bulging of the cornea, which takes on a conical shape, resulting in visual distortion.
In the early stages of KC, non-surgical measures such as glasses and contact …
L Grybauskaite, R Zemaitiene
Keratoconus (KC) is a progressive eye disease characterized by thinning and
bulging of the cornea, which takes on a conical shape, resulting in visual distortion.
In the early stages of KC, non-surgical measures such as glasses and contact …
bulging of the cornea, which takes on a conical shape, resulting in visual distortion.
In the early stages of KC, non-surgical measures such as glasses and contact …
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Comparison of the 1-year efficacy of epithelium-off and transepithelial accelerated corneal collagen crosslinking in adolescent keratoconus
Y Tang, J Jiang, C Yang, H Yin, Y Fei - Eye, 2025… keratoconus is not yet fully understood, although it is hypothesized to be related
to genetic and allergic factors. Early keratoconus is difficult to detect, and late-stage
keratoconus, … Accelerated corneal collagen crosslinking (ACXL) is a common …
Y Tang, J Jiang, C Yang, H Yin, Y Fei - Eye, 2025
… keratoconus is not yet fully understood, although it is hypothesized to be related
to genetic and allergic factors. Early keratoconus is difficult to detect, and late-stage
keratoconus, … Accelerated corneal collagen crosslinking (ACXL) is a common …
to genetic and allergic factors. Early keratoconus is difficult to detect, and late-stage
keratoconus, … Accelerated corneal collagen crosslinking (ACXL) is a common …
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[HTML] A novel large diameter rigid gas-permeable corneal contact lens design for keratoconus
M Larrosa, N Lupón, J Gispets, G Cardona - Journal of Optometry, 2025Purpose To assess the fitting process and clinical feasibility of a novel large
diameter rigid gas-permeable (RGP) corneal contact lens (CL) presenting regular or
reverse geometry for managing keratoconus (KC). The lens was designed to rest on …
M Larrosa, N Lupón, J Gispets, G Cardona - Journal of Optometry, 2025
Purpose To assess the fitting process and clinical feasibility of a novel large
diameter rigid gas-permeable (RGP) corneal contact lens (CL) presenting regular or
reverse geometry for managing keratoconus (KC). The lens was designed to rest on …
diameter rigid gas-permeable (RGP) corneal contact lens (CL) presenting regular or
reverse geometry for managing keratoconus (KC). The lens was designed to rest on …
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Analysis of progranulin concentration in corneal epithelium and tears as a possible biomarker in the clinical diagnosis and progression of keratoconus
G Akcan, ENG Özkan, GD Can - International Ophthalmology, 2025… keratoconus, the epithelial layer can be compromised, and progranulin might
help in maintaining or restoring epithelial integrity. This study is the next step
designed as a basic preliminary study to examine the therapeutic effect of PGRN in …
G Akcan, ENG Özkan, GD Can - International Ophthalmology, 2025
… keratoconus, the epithelial layer can be compromised, and progranulin might
help in maintaining or restoring epithelial integrity. This study is the next step
designed as a basic preliminary study to examine the therapeutic effect of PGRN in …
help in maintaining or restoring epithelial integrity. This study is the next step
designed as a basic preliminary study to examine the therapeutic effect of PGRN in …
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Omics in Keratoconus: From Molecular to Clinical Practice
SC Durán-Cristiano, A Bustamante-Arias… - Journal of Clinical Medicine, 2025… Keratoconus (KC) is a progressive ocular disorder marked by structural and
functional … This review aims to describe findings from omics research applied to
keratoconus, highlighting … studies hold promise for identifying biomarkers of …
SC Durán-Cristiano, A Bustamante-Arias… - Journal of Clinical Medicine, 2025
… Keratoconus (KC) is a progressive ocular disorder marked by structural and
functional … This review aims to describe findings from omics research applied to
keratoconus, highlighting … studies hold promise for identifying biomarkers of …
functional … This review aims to describe findings from omics research applied to
keratoconus, highlighting … studies hold promise for identifying biomarkers of …
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[HTML] Advances in machine learning for keratoconus diagnosis
ZJ Muhsin, R Qahwaji, I Ghafir, M AlShawabkeh… - International Ophthalmology, 2025Purpose To review studies reporting the role of Machine Learning (ML) techniques
in the diagnosis of keratoconus (KC) over the past decade, shedding light on recent
developments while also highlighting the existing gaps between academic research …
ZJ Muhsin, R Qahwaji, I Ghafir, M AlShawabkeh… - International Ophthalmology, 2025
Purpose To review studies reporting the role of Machine Learning (ML) techniques
in the diagnosis of keratoconus (KC) over the past decade, shedding light on recent
developments while also highlighting the existing gaps between academic research …
in the diagnosis of keratoconus (KC) over the past decade, shedding light on recent
developments while also highlighting the existing gaps between academic research …
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[HTML] Influence of Crosslinking on Astigmatism Vector in Keratoconus: A Vector Analysis
S Marx-Gross, AJ Winter, D Wollschlaeger… - Ophthalmology and Therapy, 2025… Corneal cross linking (CXL) is an appropriate method to treat progressive
keratoconus in … astigmatism is suitable for quantifying keratoconus progression or
demonstrating stability. … a total of 74 eyes diagnosed with progressive …
S Marx-Gross, AJ Winter, D Wollschlaeger… - Ophthalmology and Therapy, 2025
… Corneal cross linking (CXL) is an appropriate method to treat progressive
keratoconus in … astigmatism is suitable for quantifying keratoconus progression or
demonstrating stability. … a total of 74 eyes diagnosed with progressive …
keratoconus in … astigmatism is suitable for quantifying keratoconus progression or
demonstrating stability. … a total of 74 eyes diagnosed with progressive …
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Keratoconus: A Probe Into The Refractive Symmetry
S Sankhajyoti, DP Ranjan, SN Bandyopadhyay… - 2025… of keratoconus severity, prospecting that mirror otant possessed a significant
impact on the trajectory of the disorder. This study included patients with clinically
diagnosed with bilateral keratoconus and … Pentacam enable the observation of …
S Sankhajyoti, DP Ranjan, SN Bandyopadhyay… - 2025
… of keratoconus severity, prospecting that mirror otant possessed a significant
impact on the trajectory of the disorder. This study included patients with clinically
diagnosed with bilateral keratoconus and … Pentacam enable the observation of …
impact on the trajectory of the disorder. This study included patients with clinically
diagnosed with bilateral keratoconus and … Pentacam enable the observation of …
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Evaluating the Accuracy and Readability of ChatGPT-4o's Responses to Patient-Based Questions about Keratoconus
AS Balci, S Çakmak - Ophthalmic Epidemiology, 2025Purpose This study aimed to evaluate the accuracy and readability of responses
generated by ChatGPT-4o, an advanced large language model, to frequently asked
patient-centered questions about keratoconus. Methods A cross-sectional …
AS Balci, S Çakmak - Ophthalmic Epidemiology, 2025
Purpose This study aimed to evaluate the accuracy and readability of responses
generated by ChatGPT-4o, an advanced large language model, to frequently asked
patient-centered questions about keratoconus. Methods A cross-sectional …
generated by ChatGPT-4o, an advanced large language model, to frequently asked
patient-centered questions about keratoconus. Methods A cross-sectional …
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[PDF] Optimizing Visual Quality in Keratoconus: A Review of Recent Advances
K Kowalik, M Michalska, A Zielińska, S Szypulski… - Quality in Sport, 2025Keratoconus (KC) is a progressive, bilateral, and asymmetric corneal disorder that
results in corneal thinning and conical protrusion, causing irregular astigmatism and
reduced visual acuity. KC prevalence varies widely, with onset typically in the …
K Kowalik, M Michalska, A Zielińska, S Szypulski… - Quality in Sport, 2025
Keratoconus (KC) is a progressive, bilateral, and asymmetric corneal disorder that
results in corneal thinning and conical protrusion, causing irregular astigmatism and
reduced visual acuity. KC prevalence varies widely, with onset typically in the …
results in corneal thinning and conical protrusion, causing irregular astigmatism and
reduced visual acuity. KC prevalence varies widely, with onset typically in the …
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Early results of allograft intrastromal ring segment for keratoconus
ZY Karaca, FFNK Perk, EC Yesilkaya, Z Burke… - Journal Français d' …, 2025Purpose This study aimed to determine the efficacy of a novel nomogram for
implanting allograft intrastromal ring segments in keratoconus patients. Materials
and methods The study included 86 eyes of 86 patients who were followed for 6 …
ZY Karaca, FFNK Perk, EC Yesilkaya, Z Burke… - Journal Français d' …, 2025
Purpose This study aimed to determine the efficacy of a novel nomogram for
implanting allograft intrastromal ring segments in keratoconus patients. Materials
and methods The study included 86 eyes of 86 patients who were followed for 6 …
implanting allograft intrastromal ring segments in keratoconus patients. Materials
and methods The study included 86 eyes of 86 patients who were followed for 6 …
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[PDF] Treatment of duck-phenotype keratoconus using asymmetric intrastromal corneal ring-segments with hybrid technique
D Perez, FR Saudel, CA Benatti - Oftalmología Clínica y Experimental, 2025Objective: To evaluate the safety and efficacy of using asymmetric intrastromal
corneal ring-segments (ICRS) for the treatment of duck-phenotype keratoconus
through an hybrid technique. Methods: A retrospective study was performed in a …
D Perez, FR Saudel, CA Benatti - Oftalmología Clínica y Experimental, 2025
Objective: To evaluate the safety and efficacy of using asymmetric intrastromal
corneal ring-segments (ICRS) for the treatment of duck-phenotype keratoconus
through an hybrid technique. Methods: A retrospective study was performed in a …
corneal ring-segments (ICRS) for the treatment of duck-phenotype keratoconus
through an hybrid technique. Methods: A retrospective study was performed in a …
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Outcomes of localized corneal collagen crosslinking with a conventional device in progressive keratoconus
OV Berar, R Shemesh, N Gomel, Y Berger, IS Barequet - … von Graefes Archiv fur klinische und …… To evaluate the outcomes of localized crosslinking (L-CXL) for progressive
keratoconus utilizing a standard CXL device. … included patients diagnosed with
progressive keratoconus and treated with a localized cone-centered CXL (based on …
OV Berar, R Shemesh, N Gomel, Y Berger, IS Barequet - … von Graefes Archiv fur klinische und …
… To evaluate the outcomes of localized crosslinking (L-CXL) for progressive
keratoconus utilizing a standard CXL device. … included patients diagnosed with
progressive keratoconus and treated with a localized cone-centered CXL (based on …
keratoconus utilizing a standard CXL device. … included patients diagnosed with
progressive keratoconus and treated with a localized cone-centered CXL (based on …
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[HTML] Visual and topographic outcomes after Corneal Allogeneic Intrastromal Ring Segments (CAIRS) for keratoconus: a systematic review and meta-analysis
M Friedrich, GU Auffarth, U Soiberman, VA Augustin… - American Journal of …, 2025Purpose Corneal allogeneic intrastromal ring segments (CAIRS) are a novel
therapeutic approach to treat ectatic diseases such as keratoconus and improve
visual acuity as well as corneal topography. This analysis aimed to evaluate the …
M Friedrich, GU Auffarth, U Soiberman, VA Augustin… - American Journal of …, 2025
Purpose Corneal allogeneic intrastromal ring segments (CAIRS) are a novel
therapeutic approach to treat ectatic diseases such as keratoconus and improve
visual acuity as well as corneal topography. This analysis aimed to evaluate the …
therapeutic approach to treat ectatic diseases such as keratoconus and improve
visual acuity as well as corneal topography. This analysis aimed to evaluate the …
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[HTML] Regional Biomechanical Weakening in Keratoconus Corneas Detected by In Vivo High-Frequency Ultrasound Elastography
S Kwok, X Pan, M Pan, Z Chen, M Ammon… - Translational Vision Science …, 2025… /surgeries or clinical signs of keratoconus were enrolled in this study. Forty
patients with a clinical diagnosis of keratoconus were recruited from those receiving
eye care at the Ohio State University Havener Eye Institute. Keratoconus was …
S Kwok, X Pan, M Pan, Z Chen, M Ammon… - Translational Vision Science …, 2025
… /surgeries or clinical signs of keratoconus were enrolled in this study. Forty
patients with a clinical diagnosis of keratoconus were recruited from those receiving
eye care at the Ohio State University Havener Eye Institute. Keratoconus was …
patients with a clinical diagnosis of keratoconus were recruited from those receiving
eye care at the Ohio State University Havener Eye Institute. Keratoconus was …
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[HTML] Outcomes of localized corneal collagen crosslinking with a conventional device in progressive keratoconus
O Vorobichik Berar, R Shemesh, N Gomel, Y Berger… - Graefe's Archive for Clinical …, 2025… and is considered the gold standard treatment for stabilizing progressive
keratoconus in many countries [2,3,4,5]. In April 2016, the US … progressive
keratoconus and post-LASIK ectasia. Based on the early observation of improved …
O Vorobichik Berar, R Shemesh, N Gomel, Y Berger… - Graefe's Archive for Clinical …, 2025
… and is considered the gold standard treatment for stabilizing progressive
keratoconus in many countries [2,3,4,5]. In April 2016, the US … progressive
keratoconus and post-LASIK ectasia. Based on the early observation of improved …
keratoconus in many countries [2,3,4,5]. In April 2016, the US … progressive
keratoconus and post-LASIK ectasia. Based on the early observation of improved …
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A new morphological classification of keratoconus using few-shot learning in candidates for intrastromal corneal ring implants
M Shirshekardo, AH Taherinia - Journal of Biomedical Signal Processing and …, 2025In the field of ophthalmology, the accurate classification of different types of
keratoconus (KCN) is vital for effective surgical planning and the successful
implantation of intracorneal ring segments (ICRS). During the diagnostic process …
M Shirshekardo, AH Taherinia - Journal of Biomedical Signal Processing and …, 2025
In the field of ophthalmology, the accurate classification of different types of
keratoconus (KCN) is vital for effective surgical planning and the successful
implantation of intracorneal ring segments (ICRS). During the diagnostic process …
keratoconus (KCN) is vital for effective surgical planning and the successful
implantation of intracorneal ring segments (ICRS). During the diagnostic process …
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[HTML] Comparing the Performance of Stress-Strain Index Versions 1 and 2 in Normal and Keratoconus Patients
NJ Lu, M Jiménez-García, A Elsheikh, A Makarem… - Translational Vision Science …, 2025Purpose: The purpose of this study was to compare the performance of the Stress-Strain
Index versions 1 and 2 (SSI and SSI2) in healthy patients and patients with
keratoconus (KC). Methods: Fifty-two healthy and 104 KC eyes were examined …
NJ Lu, M Jiménez-García, A Elsheikh, A Makarem… - Translational Vision Science …, 2025
Purpose: The purpose of this study was to compare the performance of the Stress-Strain
Index versions 1 and 2 (SSI and SSI2) in healthy patients and patients with
keratoconus (KC). Methods: Fifty-two healthy and 104 KC eyes were examined …
Index versions 1 and 2 (SSI and SSI2) in healthy patients and patients with
keratoconus (KC). Methods: Fifty-two healthy and 104 KC eyes were examined …
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Femtosecond laser-assisted customized corneal allogenic intrastromal ring segments in patients with keratoconus after intrastromal corneal ring segment explantation …
BN Susanna, AS Forseto, AS Moriyama, MR Santhiago… - Journal of Cataract & …, 2025… In this study, we describe 8 cases of customized CAIRS in keratoconus patients
with previous ICRS explantation. The mean age was 30.5 ± 6.3 years old (range, 24
to 42 years), and 6 patients (75%) were female. Preoperative thinnest tomographic …
BN Susanna, AS Forseto, AS Moriyama, MR Santhiago… - Journal of Cataract & …, 2025
… In this study, we describe 8 cases of customized CAIRS in keratoconus patients
with previous ICRS explantation. The mean age was 30.5 ± 6.3 years old (range, 24
to 42 years), and 6 patients (75%) were female. Preoperative thinnest tomographic …
with previous ICRS explantation. The mean age was 30.5 ± 6.3 years old (range, 24
to 42 years), and 6 patients (75%) were female. Preoperative thinnest tomographic …
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[PDF] Theory of Systems and Understanding Keratoconus A Comparative Approach with Marfan Syndrome, Down Syndrome, and Immune System Inflammatory Factors
K Zehtabian - Universal Library of Medical and Health Sciences, 2025Keratoconus (KC) is a progressive corneal ectasia driven by genetic, oxidative, and
inflammatory mechanisms. This study employs systems theory and Bayesian
modeling to dissect KC's genetic overlaps with Marfan syndrome (MFS) and Down …
K Zehtabian - Universal Library of Medical and Health Sciences, 2025
Keratoconus (KC) is a progressive corneal ectasia driven by genetic, oxidative, and
inflammatory mechanisms. This study employs systems theory and Bayesian
modeling to dissect KC's genetic overlaps with Marfan syndrome (MFS) and Down …
inflammatory mechanisms. This study employs systems theory and Bayesian
modeling to dissect KC's genetic overlaps with Marfan syndrome (MFS) and Down …
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Corneal Tissue Addition Keratoplasty for the Treatment of Keratoconus: A Review
D Ballouz, PM Dmitriev, BD Ayres - International Ophthalmology Clinics, 2025Keratoconus, characterized by loss of corneal structural integrity causing stromal
thinning, has both surgical and nonsurgical management options. While corneal
cross-linking is being increasingly used to halt the progression of keratoconus, it is …
D Ballouz, PM Dmitriev, BD Ayres - International Ophthalmology Clinics, 2025
Keratoconus, characterized by loss of corneal structural integrity causing stromal
thinning, has both surgical and nonsurgical management options. While corneal
cross-linking is being increasingly used to halt the progression of keratoconus, it is …
thinning, has both surgical and nonsurgical management options. While corneal
cross-linking is being increasingly used to halt the progression of keratoconus, it is …
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[PDF] Depth-related visuomotor performance in keratoconus and its relationship to stereopsis
P Devi, C Bengra, D Kumar, R Deshmukh, P Vaddavalli… - … Ophthalmology and Visual …, 2025… limitations on the depth-related 88 visuomotor task performance in keratoconus
were investigated in the present study. The primary 89 … Diagnosis of keratoconus
was based on a comprehensive eye examination that showed 128 evidence of …
P Devi, C Bengra, D Kumar, R Deshmukh, P Vaddavalli… - … Ophthalmology and Visual …, 2025
… limitations on the depth-related 88 visuomotor task performance in keratoconus
were investigated in the present study. The primary 89 … Diagnosis of keratoconus
was based on a comprehensive eye examination that showed 128 evidence of …
were investigated in the present study. The primary 89 … Diagnosis of keratoconus
was based on a comprehensive eye examination that showed 128 evidence of …
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Machine learning-based progress prediction in accelerated cross-linking for Keratoconus
Q Wan, Q Wang, R Wei, J Tang, H Yin, Y Deng, K Ma - Graefe's Archive for Clinical …, 2025… and compare corneal topographic and biomechanical parameters in patients with
keratoconus before undergoing A-CXL surgery. Besides, … treatment and provided
more accurate predictions and individualized treatment strategies for the …
Q Wan, Q Wang, R Wei, J Tang, H Yin, Y Deng, K Ma - Graefe's Archive for Clinical …, 2025
… and compare corneal topographic and biomechanical parameters in patients with
keratoconus before undergoing A-CXL surgery. Besides, … treatment and provided
more accurate predictions and individualized treatment strategies for the …
keratoconus before undergoing A-CXL surgery. Besides, … treatment and provided
more accurate predictions and individualized treatment strategies for the …
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[HTML] Relationship between objective and subjective refraction measurements in patients with mild keratoconus
M Khorrami-Nejad, AK Dakhil, H Hashemian… - International Journal of …, 2025AIM To compare objective dry retinoscopy and subjective refraction measurements
in patients with mild keratoconus (KCN) and quantify any differences. METHODS
This cross-sectional study was done on 68 eyes of 68 patients diagnosed with mild …
M Khorrami-Nejad, AK Dakhil, H Hashemian… - International Journal of …, 2025
AIM To compare objective dry retinoscopy and subjective refraction measurements
in patients with mild keratoconus (KCN) and quantify any differences. METHODS
This cross-sectional study was done on 68 eyes of 68 patients diagnosed with mild …
in patients with mild keratoconus (KCN) and quantify any differences. METHODS
This cross-sectional study was done on 68 eyes of 68 patients diagnosed with mild …
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[HTML] Corneal cross-linking effects on ocular surface parameters and corneal topographic and optical characteristics in progressive keratoconus cases: a prospective single …
N Taheri, A Lotfi Sadigh, S Abed Nikmanesh… - BMC Ophthalmology, 2025This study aims to evaluate the effects of epithelial-off corneal cross-linking (CXL) on
the ocular surface and corneal topographic and optical parameters in progressive
keratoconus (KCN) cases. Prospective single-arm interventional study. Thirty eyes of …
N Taheri, A Lotfi Sadigh, S Abed Nikmanesh… - BMC Ophthalmology, 2025
This study aims to evaluate the effects of epithelial-off corneal cross-linking (CXL) on
the ocular surface and corneal topographic and optical parameters in progressive
keratoconus (KCN) cases. Prospective single-arm interventional study. Thirty eyes of …
the ocular surface and corneal topographic and optical parameters in progressive
keratoconus (KCN) cases. Prospective single-arm interventional study. Thirty eyes of …
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A New Era in Keratoconus Diagnosis: The Comprehensive Belin ABCD Approach
A Jha… was the go-to method for diagnosing keratoconus. Developed in the 1940s, this
system relied … as modern imaging has revealed how keratoconus affects deeper
layers of the cornea. (2) … point (not just the apex), this system is much more …
A Jha
… was the go-to method for diagnosing keratoconus. Developed in the 1940s, this
system relied … as modern imaging has revealed how keratoconus affects deeper
layers of the cornea. (2) … point (not just the apex), this system is much more …
system relied … as modern imaging has revealed how keratoconus affects deeper
layers of the cornea. (2) … point (not just the apex), this system is much more …
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Paired eye comparison of baseline parameters and tomographic characteristics prior to hydrops in patients with keratoconus
P Sudanaboina, MH Ali, S Chaurasia - International Ophthalmology, 2025… the management of keratoconus. Identifying the patients with high-risk
characteristics for development of hydrops in keratoconus is important … was
conducted to analyse the clinical profile and baseline tomographic risk factors in …
P Sudanaboina, MH Ali, S Chaurasia - International Ophthalmology, 2025
… the management of keratoconus. Identifying the patients with high-risk
characteristics for development of hydrops in keratoconus is important … was
conducted to analyse the clinical profile and baseline tomographic risk factors in …
characteristics for development of hydrops in keratoconus is important … was
conducted to analyse the clinical profile and baseline tomographic risk factors in …
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[PDF] Electromyographic Study for the Objective Evaluation of Glare-Induced Discomfort in Patients With Keratoconus
AD Plaka, S Plainis, P Chatzakis, G Kontadakis… - Cureus, 2025… -progressive keratoconus or progressive keratoconus at least one year after
corneal crosslinking. This time period was selected to avoid measuring the
discomfort glare affected by the early postoperative period. All patients were graded …
AD Plaka, S Plainis, P Chatzakis, G Kontadakis… - Cureus, 2025
… -progressive keratoconus or progressive keratoconus at least one year after
corneal crosslinking. This time period was selected to avoid measuring the
discomfort glare affected by the early postoperative period. All patients were graded …
corneal crosslinking. This time period was selected to avoid measuring the
discomfort glare affected by the early postoperative period. All patients were graded …
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[HTML] Anterior and Posterior Corneal Higher-order Aberrations in Keratoconus and Pellucid Marginal Corneal Degeneration by Pentacam
S Kumari, V Sharma, SK Chaurasiya, A Khurana… - Delhi Journal of …, 2025… Keratoconus (KC) is bilateral noninflammatory progressive corneal ectasia
characterized by stromal thinning, which results in irregular astigmatism and visual
impairment. [ 1 ] The incidence of keratoconus is approximately 1 per 2000 in the …
S Kumari, V Sharma, SK Chaurasiya, A Khurana… - Delhi Journal of …, 2025
… Keratoconus (KC) is bilateral noninflammatory progressive corneal ectasia
characterized by stromal thinning, which results in irregular astigmatism and visual
impairment. [ 1 ] The incidence of keratoconus is approximately 1 per 2000 in the …
characterized by stromal thinning, which results in irregular astigmatism and visual
impairment. [ 1 ] The incidence of keratoconus is approximately 1 per 2000 in the …
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[HTML] Keratoconus as a Rare Manifestation of Hypohidrotic Ectodermal Dysplasia
T Chandel, A Gupta, G Sharma, KS Mehta, A Negi… - Delhi Journal of …, 2025… Our case report highlights the rare coexistence of HED and keratoconus. The
patient's clinical presentation; sparse scalp hair, scanty and … and sparse
eyelashes and keratoconus. However, there is no established protocol for routine …
T Chandel, A Gupta, G Sharma, KS Mehta, A Negi… - Delhi Journal of …, 2025
… Our case report highlights the rare coexistence of HED and keratoconus. The
patient's clinical presentation; sparse scalp hair, scanty and … and sparse
eyelashes and keratoconus. However, there is no established protocol for routine …
patient's clinical presentation; sparse scalp hair, scanty and … and sparse
eyelashes and keratoconus. However, there is no established protocol for routine …
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The Distribution of Keratoconus Assessed Using Belin/Ambrósio Parameters According to Age and Gender in a Tertiary Eye Center: A Cross-Sectional Study
AH REYHAN, A SAĞLIK, M BERHUNİ, N YILDIRIM - 2025… This study compares keratoconus characteristics across different pediatric and
adult populations in a tertiary eye center. We used Pentacam HR … The findings
yield insights capable of informing clinical decision-making and therapeutic …
AH REYHAN, A SAĞLIK, M BERHUNİ, N YILDIRIM - 2025
… This study compares keratoconus characteristics across different pediatric and
adult populations in a tertiary eye center. We used Pentacam HR … The findings
yield insights capable of informing clinical decision-making and therapeutic …
adult populations in a tertiary eye center. We used Pentacam HR … The findings
yield insights capable of informing clinical decision-making and therapeutic …
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[PDF] Assessment of the Effect of Corneal Collagen Cross-Linking on Corneal Endothelium in Patients with Keratoconus
SH Elsayed, MS Badawy, AA Abdel-Ghany… - The Egyptian Journal of Hospital …… of progressive keratoconus. Patients and methods: Included 30 eyes from twenty-four
individuals diagnosed with keratoconus. Endothelial cell … Furthermore, the
correlation between keratoconus stage and changes in CCT, HEX, and CV didn`t …
SH Elsayed, MS Badawy, AA Abdel-Ghany… - The Egyptian Journal of Hospital …
… of progressive keratoconus. Patients and methods: Included 30 eyes from twenty-four
individuals diagnosed with keratoconus. Endothelial cell … Furthermore, the
correlation between keratoconus stage and changes in CCT, HEX, and CV didn`t …
individuals diagnosed with keratoconus. Endothelial cell … Furthermore, the
correlation between keratoconus stage and changes in CCT, HEX, and CV didn`t …
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Corneal epithelium is altered in keratoconus and forme fruste keratoconus
N Sukhee, H Namba, M Ikeda, S Ichinohasama… - 2025This study investigated the corneal epithelial thickness and its distribution in
keratoconus (KC) and forme fruste keratoconus (FFK). We recruited 144 KC eyes
and 27 FFK eyes from 76 participants (50 men and 26 women) who underwent …
N Sukhee, H Namba, M Ikeda, S Ichinohasama… - 2025
This study investigated the corneal epithelial thickness and its distribution in
keratoconus (KC) and forme fruste keratoconus (FFK). We recruited 144 KC eyes
and 27 FFK eyes from 76 participants (50 men and 26 women) who underwent …
keratoconus (KC) and forme fruste keratoconus (FFK). We recruited 144 KC eyes
and 27 FFK eyes from 76 participants (50 men and 26 women) who underwent …
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Porcine Collagen Implants in Advanced Keratoconus: Outcomes at 1 Year
R Deshmukh, RM Mohan, V Madonadi Kuniyil… - Journal of Refractive …, 2025… DISCUSSION The current study reports the results of 9 eyes with advanced
keratoconus that underwent Xenia lenticule implantation. Two … 's layer
transplantation to improve the biomechanical strength in keratoconus.Patients with …
R Deshmukh, RM Mohan, V Madonadi Kuniyil… - Journal of Refractive …, 2025
… DISCUSSION The current study reports the results of 9 eyes with advanced
keratoconus that underwent Xenia lenticule implantation. Two … 's layer
transplantation to improve the biomechanical strength in keratoconus.Patients with …
keratoconus that underwent Xenia lenticule implantation. Two … 's layer
transplantation to improve the biomechanical strength in keratoconus.Patients with …
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Non-corneal Intraocular Higher Order Aberrations in Eyes With Keratoconus Versus Normal Myopic Eyes
K Kozhaya, CJ Mehanna, L Asroui, R Bejjani… - Journal of Refractive …, 2025… Patients with diagnosed keratoconus who presented for evaluation at our center
and patients … Keratoconus diagnosis was confirmed according to previously
described standards.These … , highly sensitive and specific for the diagnosis of …
K Kozhaya, CJ Mehanna, L Asroui, R Bejjani… - Journal of Refractive …, 2025
… Patients with diagnosed keratoconus who presented for evaluation at our center
and patients … Keratoconus diagnosis was confirmed according to previously
described standards.These … , highly sensitive and specific for the diagnosis of …
and patients … Keratoconus diagnosis was confirmed according to previously
described standards.These … , highly sensitive and specific for the diagnosis of …
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[HTML] Pilot Programme for Keratoconus Screening and Management in Adolescents with Down Syndrome
B Power, KAJ Stephenson, D Malata, C Murphy, B Quill… - Diagnostics, 2025… ) screened had tomographic evidence of keratoconus requiring treatment at their
first review. We found an increased incidence of keratoconus in European
individuals with … We advocate tomographic keratoconus screening for individuals …
B Power, KAJ Stephenson, D Malata, C Murphy, B Quill… - Diagnostics, 2025
… ) screened had tomographic evidence of keratoconus requiring treatment at their
first review. We found an increased incidence of keratoconus in European
individuals with … We advocate tomographic keratoconus screening for individuals …
first review. We found an increased incidence of keratoconus in European
individuals with … We advocate tomographic keratoconus screening for individuals …
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[HTML] Population Effect of Croslinking Treatment for Keratoconus in a Pediatric Population
B Pandurevic, M Ahmedbegovic-Pjano, S Grisevic… - Acta Informatica Medica, 2024… The aim of this study was to evaluate the effectiveness of the accelerated
crosslinking treatment for keratoconus in the pediatric population… keratoconus
patient, thus early diagnosis is imperative. Crosslinking is a safe procedure and the …
B Pandurevic, M Ahmedbegovic-Pjano, S Grisevic… - Acta Informatica Medica, 2024
… The aim of this study was to evaluate the effectiveness of the accelerated
crosslinking treatment for keratoconus in the pediatric population… keratoconus
patient, thus early diagnosis is imperative. Crosslinking is a safe procedure and the …
crosslinking treatment for keratoconus in the pediatric population… keratoconus
patient, thus early diagnosis is imperative. Crosslinking is a safe procedure and the …
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A Cross-sectional Analysis of Vision Related Quality of Life in Adult Patients With Keratoconus in Nairobi
GG Ngare - 2024… scores in adult patients with keratoconus. Recommendation: This study
recommends the formation of adult keratoconus support groups targeting patients
under 30 year, an emphasis psychological counselling during eye care for all …
GG Ngare - 2024
… scores in adult patients with keratoconus. Recommendation: This study
recommends the formation of adult keratoconus support groups targeting patients
under 30 year, an emphasis psychological counselling during eye care for all …
recommends the formation of adult keratoconus support groups targeting patients
under 30 year, an emphasis psychological counselling during eye care for all …
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Digital Transformation of Care for Keratoconus Patients: ML Modelling Structural Outcomes of Corneal Collagen Cross-Linking
Y Statsenko, D Smetanina, R Voitetskii, G Simiyu… - Frontiers in MedicineBackground: Structural outcomes of corneal collagen cross-linking (CXL) have not
been thoroughly investigated. Clinical risk assessment would benefit from a reliable
prognosis of postoperative minimal (MCT) and central corneal thickness (CCT) …
Y Statsenko, D Smetanina, R Voitetskii, G Simiyu… - Frontiers in Medicine
Background: Structural outcomes of corneal collagen cross-linking (CXL) have not
been thoroughly investigated. Clinical risk assessment would benefit from a reliable
prognosis of postoperative minimal (MCT) and central corneal thickness (CCT) …
been thoroughly investigated. Clinical risk assessment would benefit from a reliable
prognosis of postoperative minimal (MCT) and central corneal thickness (CCT) …
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[PDF] Hydrops as a Presenting Sign of Keratoconus in Down Syndrome: Case Report, Literature Review, and the Need for a Public Health Strategy
A Barbara, C Mazzotta, M Sinjab, R Barbara - International Journal of Keratoconus …, 2025… sign of keratoconus in the left eye and concurrent keratoconus in the right eye.
The discussion stresses the frequent occurrence of keratoconus … associated with
keratoconus in this population. Keywords: Case report, Central corneal thickness …
A Barbara, C Mazzotta, M Sinjab, R Barbara - International Journal of Keratoconus …, 2025
… sign of keratoconus in the left eye and concurrent keratoconus in the right eye.
The discussion stresses the frequent occurrence of keratoconus … associated with
keratoconus in this population. Keywords: Case report, Central corneal thickness …
The discussion stresses the frequent occurrence of keratoconus … associated with
keratoconus in this population. Keywords: Case report, Central corneal thickness …
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Optimizing riboflavin delivery with co-crystal and in situ hydrogel formulations for management of keratoconus: A comprehensive investigation with in vitro, ex vivo and …
E Aytekin, MZ Kaya, GE İlkar, HK Polat, N Öztürk… - International Journal of …, 2025Keratoconus is a progressive disease characterized by corneal thinning and conical
deformation. Corneal cross-linking, a common treatment, strengthens collagen fibers
using vitamin B2 (riboflavin) and UVA light. However, the surgical removal of the …
E Aytekin, MZ Kaya, GE İlkar, HK Polat, N Öztürk… - International Journal of …, 2025
Keratoconus is a progressive disease characterized by corneal thinning and conical
deformation. Corneal cross-linking, a common treatment, strengthens collagen fibers
using vitamin B2 (riboflavin) and UVA light. However, the surgical removal of the …
deformation. Corneal cross-linking, a common treatment, strengthens collagen fibers
using vitamin B2 (riboflavin) and UVA light. However, the surgical removal of the …
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[HTML] Corneal Infection Complicating Acute Corneal Hydrops in Keratoconus Patients
K Kitazawa, R Kozaki, Y Yamashita, T Aichi, M Itoi… - American Journal of …, 2025Purpose Acute corneal hydrops (ACH) occurs during the follow-up of keratoconus,
presenting as severe corneal edema due to Descemet's membrane rupture.
Infectious keratitis can cause corneal edema accompanied by corneal infiltrations …
K Kitazawa, R Kozaki, Y Yamashita, T Aichi, M Itoi… - American Journal of …, 2025
Purpose Acute corneal hydrops (ACH) occurs during the follow-up of keratoconus,
presenting as severe corneal edema due to Descemet's membrane rupture.
Infectious keratitis can cause corneal edema accompanied by corneal infiltrations …
presenting as severe corneal edema due to Descemet's membrane rupture.
Infectious keratitis can cause corneal edema accompanied by corneal infiltrations …
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Keratoconus & Corneal Ectasia
L Barros, AB da Costa Neto, G Portas-Almeida… - Cornea Casebook, 2025Keratoconus is the most common of the primary ectasia and is characterized by
bulging and thinning of the central cornea. Having a multifactorial nature (intrinsic
biomechanical susceptibility and environmental factors), its evolution is markedly …
L Barros, AB da Costa Neto, G Portas-Almeida… - Cornea Casebook, 2025
Keratoconus is the most common of the primary ectasia and is characterized by
bulging and thinning of the central cornea. Having a multifactorial nature (intrinsic
biomechanical susceptibility and environmental factors), its evolution is markedly …
bulging and thinning of the central cornea. Having a multifactorial nature (intrinsic
biomechanical susceptibility and environmental factors), its evolution is markedly …
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Novel variations in the PLOD1, COL1A1, COL5A2 and COL4A1 genes related to keratoconus
X Zhou, X Wang, X Peng, T Han, L Sun, X Zhang - Frontiers in GeneticsPurpose: To investigate the genetic characteristics of four Chinese families affected
by keratoconus (KC).Methods: In the four families affected by KC, medical records,
clinical observations, and blood samples were collected from all individuals. One …
X Zhou, X Wang, X Peng, T Han, L Sun, X Zhang - Frontiers in Genetics
Purpose: To investigate the genetic characteristics of four Chinese families affected
by keratoconus (KC).Methods: In the four families affected by KC, medical records,
clinical observations, and blood samples were collected from all individuals. One …
by keratoconus (KC).Methods: In the four families affected by KC, medical records,
clinical observations, and blood samples were collected from all individuals. One …
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[HTML] Epithelial Mapping Efficacy for Subclinical Keratoconus Identification
BAL Dutra, B Hammoud, BN Susanna, L Asroui… - American Journal of …… Epithelial thickness patterns were not effective as a primary metric to identify
subclinical keratoconus. Scheimpflug metrics and regional … Epithelial mapping
metrics thus appear significantly less sensitive than predicted for subclinical …
BAL Dutra, B Hammoud, BN Susanna, L Asroui… - American Journal of …
… Epithelial thickness patterns were not effective as a primary metric to identify
subclinical keratoconus. Scheimpflug metrics and regional … Epithelial mapping
metrics thus appear significantly less sensitive than predicted for subclinical …
subclinical keratoconus. Scheimpflug metrics and regional … Epithelial mapping
metrics thus appear significantly less sensitive than predicted for subclinical …
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Is there a predisposition for developing corneal hydrops in keratoconus?-Tomographic and biomechanical analysis of the fellow eyes
V Bosic, H Mudassar, B Seitz, E Flockerzi - Acta ophthalmologicaAim Fellow eyes (FE) of 73 keratoconus (KC) patients with acute corneal hydrops (ACH)
and 130 KC patients without ACH (total 236 eyes, 110 more severely affected),
serving as control groups, were retrospectively analysed to identify potential risk …
V Bosic, H Mudassar, B Seitz, E Flockerzi - Acta ophthalmologica
Aim Fellow eyes (FE) of 73 keratoconus (KC) patients with acute corneal hydrops (ACH)
and 130 KC patients without ACH (total 236 eyes, 110 more severely affected),
serving as control groups, were retrospectively analysed to identify potential risk …
and 130 KC patients without ACH (total 236 eyes, 110 more severely affected),
serving as control groups, were retrospectively analysed to identify potential risk …
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[HTML] A Review of Keratoconus Cross-Linking Treatment Methods
N Papachristoforou, A Ueno, K Ledwos, J Bartuś… - Journal of Clinical Medicine, 2025Corneal collagen cross-linking (CXL) is a therapeutic intervention that utilizes
riboflavin photochemical activation with ultraviolet-A (UV-A) light to induce covalent
cross-links within the stromal corneal fibers, effectively increasing corneal …
N Papachristoforou, A Ueno, K Ledwos, J Bartuś… - Journal of Clinical Medicine, 2025
Corneal collagen cross-linking (CXL) is a therapeutic intervention that utilizes
riboflavin photochemical activation with ultraviolet-A (UV-A) light to induce covalent
cross-links within the stromal corneal fibers, effectively increasing corneal …
riboflavin photochemical activation with ultraviolet-A (UV-A) light to induce covalent
cross-links within the stromal corneal fibers, effectively increasing corneal …
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[PDF] A Study on Visual Outcome of Patients with Keratoconus after Corneal Collagen Crosslinking
BB Ahmed, TM Hassan, BQ Hamasalih - AMJ (Advanced Medical Journal), 2025… B2) and UV-A light have been shown to be effective at stopping progression of
keratoconus. … When used in treating keratoconus patients the main aim was to
stop progression, and help … study is to evaluate the effects of corneal collagen …
BB Ahmed, TM Hassan, BQ Hamasalih - AMJ (Advanced Medical Journal), 2025
… B2) and UV-A light have been shown to be effective at stopping progression of
keratoconus. … When used in treating keratoconus patients the main aim was to
stop progression, and help … study is to evaluate the effects of corneal collagen …
keratoconus. … When used in treating keratoconus patients the main aim was to
stop progression, and help … study is to evaluate the effects of corneal collagen …
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[PDF] Influencing Factors in Corneal Densitometry Recovery After Accelerated Cross‐Linking for Keratoconus
KI Huang, CY Yeh, CC Hu, SF Cheng - Journal of Ophthalmology, 2025This study examines corneal densitometry recovery and influencing factors following
accelerated corneal cross‐linking (CXL) for progressive keratoconus. Corneal
densitometry, measured using Scheimpflug tomography, provides an objective …
KI Huang, CY Yeh, CC Hu, SF Cheng - Journal of Ophthalmology, 2025
This study examines corneal densitometry recovery and influencing factors following
accelerated corneal cross‐linking (CXL) for progressive keratoconus. Corneal
densitometry, measured using Scheimpflug tomography, provides an objective …
accelerated corneal cross‐linking (CXL) for progressive keratoconus. Corneal
densitometry, measured using Scheimpflug tomography, provides an objective …
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An Integrated Approach to Keratoconus Management to Reduce Eye Health Inequity: Investigating Diagnosis, Referral, and Cost
L Angelo - 2024… and lifetime costs of subjects with keratoconus. Data was collected prospectively
through … when diagnosing or monitoring subjects with keratoconus. Only 56% of
optometrists owned a … for patients with keratoconus was estimated to be NZD …
L Angelo - 2024
… and lifetime costs of subjects with keratoconus. Data was collected prospectively
through … when diagnosing or monitoring subjects with keratoconus. Only 56% of
optometrists owned a … for patients with keratoconus was estimated to be NZD …
through … when diagnosing or monitoring subjects with keratoconus. Only 56% of
optometrists owned a … for patients with keratoconus was estimated to be NZD …
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[HTML] Subclinical parents assist in the detection of genetic variants in keratoconus by trio-based whole-exome sequencing
X Li, Y Yao, S Xing, S Ma, S Pang, Y Zhou, S Chen - 2025Methods: Trio-based whole-exome sequencing was performed in 14 keratoconus
trios containing subclinical parents. The variants identified in candidate genes of
keratoconus were analyzed by multiple bioinformatics tools. Results: We identified …
X Li, Y Yao, S Xing, S Ma, S Pang, Y Zhou, S Chen - 2025
Methods: Trio-based whole-exome sequencing was performed in 14 keratoconus
trios containing subclinical parents. The variants identified in candidate genes of
keratoconus were analyzed by multiple bioinformatics tools. Results: We identified …
trios containing subclinical parents. The variants identified in candidate genes of
keratoconus were analyzed by multiple bioinformatics tools. Results: We identified …
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Three-year Results of Customized Corneal Collagen Cross-linking for Keratoconus Patients in Oman
R Al Saidi, D Deshmukh, A Bandara, J Babu… - … Journal of Keratoconus and …, 2025Purpose: This 3-year study examined the safety and efficacy of customized corneal
collagen cross-linking (CuRV) for keratoconus in patients from Oman. Methods:
Corneal collagen cross-linking was initiated by the application of 0.1% riboflavin …
R Al Saidi, D Deshmukh, A Bandara, J Babu… - … Journal of Keratoconus and …, 2025
Purpose: This 3-year study examined the safety and efficacy of customized corneal
collagen cross-linking (CuRV) for keratoconus in patients from Oman. Methods:
Corneal collagen cross-linking was initiated by the application of 0.1% riboflavin …
collagen cross-linking (CuRV) for keratoconus in patients from Oman. Methods:
Corneal collagen cross-linking was initiated by the application of 0.1% riboflavin …
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[HTML] Histopathological characteristics of keratoconus
M Mazza, S Bergeron, D Cheema, J Coblentz… - The Pan-American Journal …, 2025Purpose: Keratoconus (KC) is a bilateral and asymmetrical corneal ectasia that
affects vision. In this study, we performed a histopathological analysis of 150 cases
of KC, to document and catalogue the primary morphological features of cornea with …
M Mazza, S Bergeron, D Cheema, J Coblentz… - The Pan-American Journal …, 2025
Purpose: Keratoconus (KC) is a bilateral and asymmetrical corneal ectasia that
affects vision. In this study, we performed a histopathological analysis of 150 cases
of KC, to document and catalogue the primary morphological features of cornea with …
affects vision. In this study, we performed a histopathological analysis of 150 cases
of KC, to document and catalogue the primary morphological features of cornea with …
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Efficacy of Customized Photorefractive Keratectomy with Cross-Linking vs. Cross-Linking Alone in Progressive Keratoconus: A Systematic Review and Meta-analysis
H Zhang, M Cantó-Cerdán, B Félix-Espinar… - American Journal of …, 2025TOPIC This review evaluates the effectiveness and safety of combining cPRK with
CXL versus CXL alone in improving visual outcomes for patients with progressive
keratoconus. DESIGN Systematic Review and Meta-Analysis CLINICAL …
H Zhang, M Cantó-Cerdán, B Félix-Espinar… - American Journal of …, 2025
TOPIC This review evaluates the effectiveness and safety of combining cPRK with
CXL versus CXL alone in improving visual outcomes for patients with progressive
keratoconus. DESIGN Systematic Review and Meta-Analysis CLINICAL …
CXL versus CXL alone in improving visual outcomes for patients with progressive
keratoconus. DESIGN Systematic Review and Meta-Analysis CLINICAL …
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[HTML] Repeatability and agreement of a new anterior segment optical coherence tomography with standard devices in normal, keratoconus, and post-refractive eyes
G Kundu, N Shetty, D Modak, L Kaweri, P Khamar… - Indian Journal of …, 2025… Bland–Altman plots showing agreement between Eyestar 900, Pentacam AXL
Wave, Anterion, and MS-39 for Sim K, pK, TCT, and ACD in keratoconus eyes. The
solid line represents the mean difference, and the dotted line represents the 95 …
G Kundu, N Shetty, D Modak, L Kaweri, P Khamar… - Indian Journal of …, 2025
… Bland–Altman plots showing agreement between Eyestar 900, Pentacam AXL
Wave, Anterion, and MS-39 for Sim K, pK, TCT, and ACD in keratoconus eyes. The
solid line represents the mean difference, and the dotted line represents the 95 …
Wave, Anterion, and MS-39 for Sim K, pK, TCT, and ACD in keratoconus eyes. The
solid line represents the mean difference, and the dotted line represents the 95 …
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Long-term effects and prognostic factors of accelerated cross-linking with retention ring-assisted riboflavin application on keratoconus progression
S Kim, WJ Choi, CH Yoon, MK Kim - Korean journal of ophthalmology: KJOPurpose To evaluate the long-term efficacy, safety, and prognostic factors of pulsed-light
accelerated corneal collagen cross-linking (A-CXL) with continuous riboflavin
application to halt keratoconus progression. Methods A-CXL with retention ring-assisted …
S Kim, WJ Choi, CH Yoon, MK Kim - Korean journal of ophthalmology: KJO
Purpose To evaluate the long-term efficacy, safety, and prognostic factors of pulsed-light
accelerated corneal collagen cross-linking (A-CXL) with continuous riboflavin
application to halt keratoconus progression. Methods A-CXL with retention ring-assisted …
accelerated corneal collagen cross-linking (A-CXL) with continuous riboflavin
application to halt keratoconus progression. Methods A-CXL with retention ring-assisted …
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Response to letter for article "Evaluation of neutrophil–lymphocyte ratio, platelet–lymphocyte ratio, and mean platelet volume levels in pediatric keratoconus patients"
M Toprak, Ö Altıntaş, Ö Yendur, BY Tuğan - Saudi Journal of Ophthalmology, 2025In our analysis, we performed a receiver operating characteristic (ROC) curve
analysis to determine the diagnostic utility of PLR and MPV in keratoconus. Using
Youden's index, we identified optimal cutoff values for these biomarkers. For PLR …
M Toprak, Ö Altıntaş, Ö Yendur, BY Tuğan - Saudi Journal of Ophthalmology, 2025
In our analysis, we performed a receiver operating characteristic (ROC) curve
analysis to determine the diagnostic utility of PLR and MPV in keratoconus. Using
Youden's index, we identified optimal cutoff values for these biomarkers. For PLR …
analysis to determine the diagnostic utility of PLR and MPV in keratoconus. Using
Youden's index, we identified optimal cutoff values for these biomarkers. For PLR …
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Comparison of Keratoconus Progression Rate between Adolescents Aged 19–24 Years and Young Adults: Impact on Indication for Crosslinking
P Kosekahya, E Flockerzi, C Munteanu, H Sideroudi… - Current Eye Research, 2025… In light of this information, it is thought that the inclusion of adolescents in adult
keratoconus studies without age grouping may lead to an underestimation of
disease severity and progression in adolescent keratoconus patients. As far as the …
P Kosekahya, E Flockerzi, C Munteanu, H Sideroudi… - Current Eye Research, 2025
… In light of this information, it is thought that the inclusion of adolescents in adult
keratoconus studies without age grouping may lead to an underestimation of
disease severity and progression in adolescent keratoconus patients. As far as the …
keratoconus studies without age grouping may lead to an underestimation of
disease severity and progression in adolescent keratoconus patients. As far as the …
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[HTML] Untargeted Tear Proteomics in a Large South-Asian Cohort Reveals Inflammatory Signaling, ECM Remodeling, and Altered Metabolism in Keratoconus
R Kannan, R Shetty, T Panigrahi, SK Koh, P Khamar… - … Ophthalmology & Visual …, 2025Purpose: Keratoconus (KC), a progressive corneal degenerative disease, is
characterized by focal thinning and weakening, and the molecular pathways driving
such changes are still being discovered. The progression-related pathologic …
R Kannan, R Shetty, T Panigrahi, SK Koh, P Khamar… - … Ophthalmology & Visual …, 2025
Purpose: Keratoconus (KC), a progressive corneal degenerative disease, is
characterized by focal thinning and weakening, and the molecular pathways driving
such changes are still being discovered. The progression-related pathologic …
characterized by focal thinning and weakening, and the molecular pathways driving
such changes are still being discovered. The progression-related pathologic …
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[HTML] An IoT-Enabled mHealth Sensing Approach for Remote Detection of Keratoconus Using Smartphone Technology
B Askarian, A Askarian, F Tabei, JW Chong - Sensors, 2025Keratoconus (KC) is a progressive eye disease and a major cause of vision
impairment and blindness worldwide. Early diagnosis is crucial for effective
management, yet conventional diagnostic methods rely on expensive and bulky …
B Askarian, A Askarian, F Tabei, JW Chong - Sensors, 2025
Keratoconus (KC) is a progressive eye disease and a major cause of vision
impairment and blindness worldwide. Early diagnosis is crucial for effective
management, yet conventional diagnostic methods rely on expensive and bulky …
impairment and blindness worldwide. Early diagnosis is crucial for effective
management, yet conventional diagnostic methods rely on expensive and bulky …
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Study on the role of sex hormones and prolactin induced proteins in keratoconus
Z Chen, W Zhang, L Gao, N Zhang, LI Jixin - International Eye Science, 2025Keratoconus (KC) is a blinding eye disease caused by a variety of factors, with its
pathogenesis still not well understood. In recent years, it has been discovered that
sex hormones and prolactin-induced protein (PIP) have a profound impact on the …
Z Chen, W Zhang, L Gao, N Zhang, LI Jixin - International Eye Science, 2025
Keratoconus (KC) is a blinding eye disease caused by a variety of factors, with its
pathogenesis still not well understood. In recent years, it has been discovered that
sex hormones and prolactin-induced protein (PIP) have a profound impact on the …
pathogenesis still not well understood. In recent years, it has been discovered that
sex hormones and prolactin-induced protein (PIP) have a profound impact on the …
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One-year clinical observation of epithelial-off accelerated corneal collagen cross-linking on the treatment of progressive keratoconus
LU Jing, MA Ping, C Lan - International Eye Science, 2025AIM: To assess the clinical efficacy and safety of epithelial-off accelerated corneal
collagen cross-linking (CXL) in the management of progressive keratoconus over 1
a period. METHODS: A retrospective pre-post self-controlled study. Data were …
LU Jing, MA Ping, C Lan - International Eye Science, 2025
AIM: To assess the clinical efficacy and safety of epithelial-off accelerated corneal
collagen cross-linking (CXL) in the management of progressive keratoconus over 1
a period. METHODS: A retrospective pre-post self-controlled study. Data were …
collagen cross-linking (CXL) in the management of progressive keratoconus over 1
a period. METHODS: A retrospective pre-post self-controlled study. Data were …
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Optical coherence tomography and pentacam imaging of concurrent keratoconus and granular corneal dystrophy
W Xie, YF Yao - Clinical and Experimental Optometry, 2025Keratoconus, a progressive bilateral corneal ectatic disorder characterised by
stromal thinning and protrusion, typically manifests … of keratoconus and granular
corneal dystrophy is a rare phenomenon. This case report presents a young male …
W Xie, YF Yao - Clinical and Experimental Optometry, 2025
Keratoconus, a progressive bilateral corneal ectatic disorder characterised by
stromal thinning and protrusion, typically manifests … of keratoconus and granular
corneal dystrophy is a rare phenomenon. This case report presents a young male …
stromal thinning and protrusion, typically manifests … of keratoconus and granular
corneal dystrophy is a rare phenomenon. This case report presents a young male …
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A new morphological classification of keratoconus using few-shot learning in candidates for intrastromal corneal ring implants
Z Agharezaei, M Shirshekar, R Firouzi, S Hassanzadeh… - … Signal Processing and …, 2025In the field of ophthalmology, the accurate classification of different types of
keratoconus (KCN) is vital for effective surgical planning and the successful
implantation of intracorneal ring segments (ICRS). During the diagnostic process …
Z Agharezaei, M Shirshekar, R Firouzi, S Hassanzadeh… - … Signal Processing and …, 2025
In the field of ophthalmology, the accurate classification of different types of
keratoconus (KCN) is vital for effective surgical planning and the successful
implantation of intracorneal ring segments (ICRS). During the diagnostic process …
keratoconus (KCN) is vital for effective surgical planning and the successful
implantation of intracorneal ring segments (ICRS). During the diagnostic process …
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[HTML] Biometry and keratometry measurements after intracorneal ring segment implantation in keratoconus patients: a pilot comparison between Pentacam AXL and IOL …
S Bamdad, A Fathian, MR Khalili, M Mohammadi… - BMC Ophthalmology, 2025… After a while using these rings was suggested for keratoconus correction and
seemed to be an alternative option for corneal transplantation or postponing this
procedure [5,6,7]. Patients with keratoconus who have undergone ICRS …
S Bamdad, A Fathian, MR Khalili, M Mohammadi… - BMC Ophthalmology, 2025
… After a while using these rings was suggested for keratoconus correction and
seemed to be an alternative option for corneal transplantation or postponing this
procedure [5,6,7]. Patients with keratoconus who have undergone ICRS …
seemed to be an alternative option for corneal transplantation or postponing this
procedure [5,6,7]. Patients with keratoconus who have undergone ICRS …
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Relevance of mitochondrial morphological changes in keratoconus patients undergoing collagen cross-linking and deep anterior lamellar keratoplasty
S Sharma, L Singh, TC Nag, S Kashyap, S Sen… - Human Cell, 2025Keratoconus (KC) is characterised by corneal stromal thinning and irregular
astigmatism, resulting in diminution of vision. Underlying aetiology remains poorly
understood. Recent evidence suggests dysregulation of oxidative balance and …
S Sharma, L Singh, TC Nag, S Kashyap, S Sen… - Human Cell, 2025
Keratoconus (KC) is characterised by corneal stromal thinning and irregular
astigmatism, resulting in diminution of vision. Underlying aetiology remains poorly
understood. Recent evidence suggests dysregulation of oxidative balance and …
astigmatism, resulting in diminution of vision. Underlying aetiology remains poorly
understood. Recent evidence suggests dysregulation of oxidative balance and …
| | | |
[PDF] Knowledge, experience and practices of optometrists in Uganda about keratoconus
G Wanok, S Arunga, B Dhillon, N Nsubuga - African Vision and Eye Health, 2025… I also recommend review depending on the extent of the keratoconus, and then
the severity. The number of reviews may differ for example if it is mild keratoconus, I
would tell them a review of 6 months to a year …' (Participant 1, private stand-alone …
G Wanok, S Arunga, B Dhillon, N Nsubuga - African Vision and Eye Health, 2025
… I also recommend review depending on the extent of the keratoconus, and then
the severity. The number of reviews may differ for example if it is mild keratoconus, I
would tell them a review of 6 months to a year …' (Participant 1, private stand-alone …
the severity. The number of reviews may differ for example if it is mild keratoconus, I
would tell them a review of 6 months to a year …' (Participant 1, private stand-alone …
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[PDF] Comparison of three measurement methods of intraocular pressure in patients with keratoconus undergoing MyoRing implantation
M Naderi, K Jadidi, SA Mosavi, AH Mohammadi… - Malaysian Journal of …, 2025Purpose: This study aimed to assess intraocular pressure (IOP) before and after
MyoRing implantation in keratoconus patients. Methods: IOP was measured in 13
eyes before and six months after MyoRing implantation using Goldmann …
M Naderi, K Jadidi, SA Mosavi, AH Mohammadi… - Malaysian Journal of …, 2025
Purpose: This study aimed to assess intraocular pressure (IOP) before and after
MyoRing implantation in keratoconus patients. Methods: IOP was measured in 13
eyes before and six months after MyoRing implantation using Goldmann …
MyoRing implantation in keratoconus patients. Methods: IOP was measured in 13
eyes before and six months after MyoRing implantation using Goldmann …
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[HTML] Corneal Epithelial Thickness Maps in Eyes with Mild and Moderate Keratoconus
P Mlyniuk, M Kaszuba-Modrzejewska… - Journal of Clinical Medicine, 2025… keratoconus, using optical coherence tomography (OCT). Methods: Fifty-two
healthy eyes (group 0), forty-one eyes with mild keratoconus (group I), and thirty
eyes with moderate keratoconus (… parameters linked with the severity of …
P Mlyniuk, M Kaszuba-Modrzejewska… - Journal of Clinical Medicine, 2025
… keratoconus, using optical coherence tomography (OCT). Methods: Fifty-two
healthy eyes (group 0), forty-one eyes with mild keratoconus (group I), and thirty
eyes with moderate keratoconus (… parameters linked with the severity of …
healthy eyes (group 0), forty-one eyes with mild keratoconus (group I), and thirty
eyes with moderate keratoconus (… parameters linked with the severity of …
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Progression of keratoconus secondary to thyroid eye disease: a case report
BA Carbonell, A Storch, C Gore - Journal of American Association for Pediatric …, 2025… keratoconus changes secondary to Graves' ophthalmopathy. To our knowledge,
concurrent keratoconus and thyroid eye disease (TED) in a child has not been
reported in the literature. Nor are there reports of rapid development of keratoconus …
BA Carbonell, A Storch, C Gore - Journal of American Association for Pediatric …, 2025
… keratoconus changes secondary to Graves' ophthalmopathy. To our knowledge,
concurrent keratoconus and thyroid eye disease (TED) in a child has not been
reported in the literature. Nor are there reports of rapid development of keratoconus …
concurrent keratoconus and thyroid eye disease (TED) in a child has not been
reported in the literature. Nor are there reports of rapid development of keratoconus …
| | | |
Penetrating Keratoplasty versus Deep Anterior Lamellar Keratoplasty for Keratoconus: A Systematic Review and Meta-Analysis of 27,018 Eyes
A A. Awad, A M. Elettreby, A A. Abo Elnaga… - Seminars in Ophthalmology, 2025… According to the aim of the work, we included studies directed towards patients
diagnosed with keratoconus who underwent DALK or PK; we included all
randomized controlled trials or observational studies that compare these two …
A A. Awad, A M. Elettreby, A A. Abo Elnaga… - Seminars in Ophthalmology, 2025
… According to the aim of the work, we included studies directed towards patients
diagnosed with keratoconus who underwent DALK or PK; we included all
randomized controlled trials or observational studies that compare these two …
diagnosed with keratoconus who underwent DALK or PK; we included all
randomized controlled trials or observational studies that compare these two …
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Ethnicity optimized indices enhance the diagnostic efficiency of early Keratoconus: A multicenter validation study
Y Huo, R Xie, J Li, J Hou, H Zou, Y Wang - Contact Lens and Anterior Eye, 2025Purpose This study aimed to evaluate the effectiveness of an ethnically-optimized
corneal tomography and biomechanics index using artificial intelligence (AI)
techniques for diagnosing early ectasia in Chinese populations and determine the …
Y Huo, R Xie, J Li, J Hou, H Zou, Y Wang - Contact Lens and Anterior Eye, 2025
Purpose This study aimed to evaluate the effectiveness of an ethnically-optimized
corneal tomography and biomechanics index using artificial intelligence (AI)
techniques for diagnosing early ectasia in Chinese populations and determine the …
corneal tomography and biomechanics index using artificial intelligence (AI)
techniques for diagnosing early ectasia in Chinese populations and determine the …
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Optical quality of the cornea one year after Cretan protocol plus in eyes with keratoconus
D Özkoyuncu Kocabaş, F Yavrum, K Özülken - Clinical and Experimental Optometry, 2025… The clinical diagnosis of keratoconus was based on Sirius corneal topography.
Progressive keratoconus has been defined as the presence of at least one of the
following changes in the last year: an increase of ≥ 1.0 diopter (D) in the Kmax value …
D Özkoyuncu Kocabaş, F Yavrum, K Özülken - Clinical and Experimental Optometry, 2025
… The clinical diagnosis of keratoconus was based on Sirius corneal topography.
Progressive keratoconus has been defined as the presence of at least one of the
following changes in the last year: an increase of ≥ 1.0 diopter (D) in the Kmax value …
Progressive keratoconus has been defined as the presence of at least one of the
following changes in the last year: an increase of ≥ 1.0 diopter (D) in the Kmax value …
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[HTML] Debunking myths about keratoconus
S Gromacki - 2025I have been caring for patients with keratoconus (KC) for 30 years. During that time,
technology and the standard of care have improved. However, the nuances of early
diagnosis can still be tricky to understand. One way to address this is by debunking …
S Gromacki - 2025
I have been caring for patients with keratoconus (KC) for 30 years. During that time,
technology and the standard of care have improved. However, the nuances of early
diagnosis can still be tricky to understand. One way to address this is by debunking …
technology and the standard of care have improved. However, the nuances of early
diagnosis can still be tricky to understand. One way to address this is by debunking …
| | | |
[HTML] Climate Determinants of Keratoconus: Insights From a Systematic Review of Prevalence
H Shabani, J De Ridder, MA Asaad, WM Bramer… - … Ophthalmology & Visual …, 2025Purpose: The reported prevalence of keratoconus varies widely worldwide, but the
causes of this variation are not well understood. We therefore aimed to explore the
potential impact of local climate variables on keratoconus prevalence. Methods: The …
H Shabani, J De Ridder, MA Asaad, WM Bramer… - … Ophthalmology & Visual …, 2025
Purpose: The reported prevalence of keratoconus varies widely worldwide, but the
causes of this variation are not well understood. We therefore aimed to explore the
potential impact of local climate variables on keratoconus prevalence. Methods: The …
causes of this variation are not well understood. We therefore aimed to explore the
potential impact of local climate variables on keratoconus prevalence. Methods: The …
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[PDF] Efficacy and Safety of Accelerated Transepithelial Corneal Crosslinking in Non-Pediatric Patients with Progressive Keratoconus: Insights from a Retrospective Cohort …
AC Chiraples, M Munteanu, HT Stanca, DM Darabus… - 2025Background/Objectives: transepithelial accelerated corneal crosslinking (TE-ACXL)
is a minimally invasive approach for stabilizing progressive keratoconus while
preserving the corneal epithelium. This study aims to evaluate changes in visual …
AC Chiraples, M Munteanu, HT Stanca, DM Darabus… - 2025
Background/Objectives: transepithelial accelerated corneal crosslinking (TE-ACXL)
is a minimally invasive approach for stabilizing progressive keratoconus while
preserving the corneal epithelium. This study aims to evaluate changes in visual …
is a minimally invasive approach for stabilizing progressive keratoconus while
preserving the corneal epithelium. This study aims to evaluate changes in visual …
| | | |
Evaluation of neutrophil–lymphocyte ratio, platelet–lymphocyte ratio, and mean platelet volume levels in pediatric keratoconus patients
MD Al-Mendalawi - Saudi Journal of Ophthalmology… [1] reported that platelet–lymphocyte ratio (PLR) and mean platelet volume (MPV)
might be new biomarkers in evaluating keratoconus among … Consequently, the
clinical applicability of study results among Turkish pediatric keratoconus patients …
MD Al-Mendalawi - Saudi Journal of Ophthalmology
… [1] reported that platelet–lymphocyte ratio (PLR) and mean platelet volume (MPV)
might be new biomarkers in evaluating keratoconus among … Consequently, the
clinical applicability of study results among Turkish pediatric keratoconus patients …
might be new biomarkers in evaluating keratoconus among … Consequently, the
clinical applicability of study results among Turkish pediatric keratoconus patients …
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[HTML] New technique for enhancing the astigmatic correction of intracorneal ring segments in keratoconus eyes with a central cone
Y Bteich, CJ Mehanna, MA Fattah, A Saad, R Antonios… - Saudi Journal of Ophthalmology… Intrastromal corneal ring segments (ICRSs) have been used extensively in
patients with keratoconus. … We evaluate our new technique in a small case series
of eyes with keratoconus with central … Results were analyzed and compared to …
Y Bteich, CJ Mehanna, MA Fattah, A Saad, R Antonios… - Saudi Journal of Ophthalmology
… Intrastromal corneal ring segments (ICRSs) have been used extensively in
patients with keratoconus. … We evaluate our new technique in a small case series
of eyes with keratoconus with central … Results were analyzed and compared to …
patients with keratoconus. … We evaluate our new technique in a small case series
of eyes with keratoconus with central … Results were analyzed and compared to …
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Extremely asymmetric ectasia: Tomographically unilateral keratoconus
H Shabani, WD Ramdas, MA Meester-Smoor… - Acta ophthalmologicaPurpose To investigate the characteristics of apparently stable forms of
tomographically unilateral keratoconus (KC). Methods In this retrospective case-control
study, strict unilaterality criteria were applied to select tomographically unilateral …
H Shabani, WD Ramdas, MA Meester-Smoor… - Acta ophthalmologica
Purpose To investigate the characteristics of apparently stable forms of
tomographically unilateral keratoconus (KC). Methods In this retrospective case-control
study, strict unilaterality criteria were applied to select tomographically unilateral …
tomographically unilateral keratoconus (KC). Methods In this retrospective case-control
study, strict unilaterality criteria were applied to select tomographically unilateral …
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[HTML] Brown-McLean syndrome secondary keratoconus
Q Wan, L Chen, R Wei, Y Deng, K Ma, J Tang - BMC Ophthalmology, 2025… Syndrome combined with bilateral keratoconus [6]. Observing the presence of
Brown-McLean Syndrome with keratoconus again in this … leading to deformation
under the pressure of the upper and lower eyelids, resulting in central protrusion …
Q Wan, L Chen, R Wei, Y Deng, K Ma, J Tang - BMC Ophthalmology, 2025
… Syndrome combined with bilateral keratoconus [6]. Observing the presence of
Brown-McLean Syndrome with keratoconus again in this … leading to deformation
under the pressure of the upper and lower eyelids, resulting in central protrusion …
Brown-McLean Syndrome with keratoconus again in this … leading to deformation
under the pressure of the upper and lower eyelids, resulting in central protrusion …
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A novel metric to monitor early progression in keratoconus: Epithelial backscatter
I Toprak, CE Gunes, C Martin-Seker, O Parca - 2025Purpose To assess the progression of keratoconus over the course of one-year
using epithelia and anterior stromal backscatter, Belin ABCD progression display,
and various Pentacam® parameters and to determine whether backscatter …
I Toprak, CE Gunes, C Martin-Seker, O Parca - 2025
Purpose To assess the progression of keratoconus over the course of one-year
using epithelia and anterior stromal backscatter, Belin ABCD progression display,
and various Pentacam® parameters and to determine whether backscatter …
using epithelia and anterior stromal backscatter, Belin ABCD progression display,
and various Pentacam® parameters and to determine whether backscatter …
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[HTML] Effect of selective suture removal on graft astigmatism after corneal transplantation in keratoconus
S Feizi, MA Javadi, Z Karjou, N Nouri, M Oraeeyazdani… - Therapeutic Advances in …, 2025… We included all patients who underwent their initial corneal transplant for
keratoconus between February 25, 1994 and January 27, 2020 … Exclusion criteria
comprised preoperative corneal vascularization, additional ocular diseases besides …
S Feizi, MA Javadi, Z Karjou, N Nouri, M Oraeeyazdani… - Therapeutic Advances in …, 2025
… We included all patients who underwent their initial corneal transplant for
keratoconus between February 25, 1994 and January 27, 2020 … Exclusion criteria
comprised preoperative corneal vascularization, additional ocular diseases besides …
keratoconus between February 25, 1994 and January 27, 2020 … Exclusion criteria
comprised preoperative corneal vascularization, additional ocular diseases besides …
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[PDF] Posterior chamber phakic intraocular lenses for correcting ametropia in stable keratoconus
O Berger, N Garikapati, H Naveed, A Hajjar-Sese… - Ophthalmic Research, 2025Introduction: The use of posterior chamber phakic intraocular lenses are a
reasonable option in the armamentarium to treat refractive error in patients with
keratoconus. We present our experience with the use of posterior chamber phakic …
O Berger, N Garikapati, H Naveed, A Hajjar-Sese… - Ophthalmic Research, 2025
Introduction: The use of posterior chamber phakic intraocular lenses are a
reasonable option in the armamentarium to treat refractive error in patients with
keratoconus. We present our experience with the use of posterior chamber phakic …
reasonable option in the armamentarium to treat refractive error in patients with
keratoconus. We present our experience with the use of posterior chamber phakic …
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[HTML] Keratoconus with two consecutive re-emergences: a case report
P Zhang, Y Wu, L Ma, D Wang - BMC ophthalmology, 2025… emergence of keratoconus is due to chronic mechanical damage to the cornea [3].
For the first time, we reported a case of consecutive keratoconus recurrence after
two consecutive deep anterior lamellar keratoplasty(DALK). Our findings suggest …
P Zhang, Y Wu, L Ma, D Wang - BMC ophthalmology, 2025
… emergence of keratoconus is due to chronic mechanical damage to the cornea [3].
For the first time, we reported a case of consecutive keratoconus recurrence after
two consecutive deep anterior lamellar keratoplasty(DALK). Our findings suggest …
For the first time, we reported a case of consecutive keratoconus recurrence after
two consecutive deep anterior lamellar keratoplasty(DALK). Our findings suggest …
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Can Chatbots Be Used for Keratoconus Patient Education?
OD Melissa Barnett - Contact Lens Spectrum, 2025In most scleral lens practices, keratoconus (KC) is one of the top indications for
scleral lens fitting. In addition to correcting corneal irregularity and visual
improvement scleral lenses can delay or reduce the need for corneal transplantation …
OD Melissa Barnett - Contact Lens Spectrum, 2025
In most scleral lens practices, keratoconus (KC) is one of the top indications for
scleral lens fitting. In addition to correcting corneal irregularity and visual
improvement scleral lenses can delay or reduce the need for corneal transplantation …
scleral lens fitting. In addition to correcting corneal irregularity and visual
improvement scleral lenses can delay or reduce the need for corneal transplantation …
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[PDF] Sociodemographic predictors of acute corneal hydrops in patients with unstable keratoconus.
LN Kanu, N Boychev, M Fry, L Margolis, C Le… - medRxiv, 2025… with unstable keratoconus. Design Retrospective case control study Subjects All
patients diagnosed with unstable keratoconus at Mass Eye … Results Of 762
patients diagnosed with unstable keratoconus, we identified 128 episodes of …
LN Kanu, N Boychev, M Fry, L Margolis, C Le… - medRxiv, 2025
… with unstable keratoconus. Design Retrospective case control study Subjects All
patients diagnosed with unstable keratoconus at Mass Eye … Results Of 762
patients diagnosed with unstable keratoconus, we identified 128 episodes of …
patients diagnosed with unstable keratoconus at Mass Eye … Results Of 762
patients diagnosed with unstable keratoconus, we identified 128 episodes of …
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[HTML] Molecular Subtype Identification and Potential Drug Prediction Based on Anoikis-Related Genes Expression in Keratoconus
Z Jiang, B Zhang, S Jia, X Yuan - Investigative Ophthalmology & Visual Science, 2025Purpose: Anoikis is a special apoptosis accompanied by the loss of extracellular
matrix (ECM) environment and the decomposition of ECM is an important process in
the occurrence of keratoconus (KC). This study aims to describe the expression …
Z Jiang, B Zhang, S Jia, X Yuan - Investigative Ophthalmology & Visual Science, 2025
Purpose: Anoikis is a special apoptosis accompanied by the loss of extracellular
matrix (ECM) environment and the decomposition of ECM is an important process in
the occurrence of keratoconus (KC). This study aims to describe the expression …
matrix (ECM) environment and the decomposition of ECM is an important process in
the occurrence of keratoconus (KC). This study aims to describe the expression …
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[HTML] Socioeconomic Factors Associated With Differential Access to Treatment in Patients With Keratoconus at a US Urban Safety-Net Hospital
OC Ihionu, JK Samra, RM Rashad, MA Arsiwala… - Cornea Open, 2025… between ADI and keratoconus treatment access, we found lower rates of CXL and
CL treatment of keratoconus and worse severity on … Keratoconus is a progressive
corneal disease characterized by bulging and thinning of the cornea, a …
OC Ihionu, JK Samra, RM Rashad, MA Arsiwala… - Cornea Open, 2025
… between ADI and keratoconus treatment access, we found lower rates of CXL and
CL treatment of keratoconus and worse severity on … Keratoconus is a progressive
corneal disease characterized by bulging and thinning of the cornea, a …
CL treatment of keratoconus and worse severity on … Keratoconus is a progressive
corneal disease characterized by bulging and thinning of the cornea, a …
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[HTML] Is there a relationship between keratoconus and diabetes?
A Chous - 2024… of keratoconus in (predominantly type 2) diabetes without complications were 20%
less likely to occur, with a 52% lower odds of keratoconus … As for some reports
linking increased risk of keratoconus to diabetes, diabetes diagnosis came after the …
A Chous - 2024
… of keratoconus in (predominantly type 2) diabetes without complications were 20%
less likely to occur, with a 52% lower odds of keratoconus … As for some reports
linking increased risk of keratoconus to diabetes, diabetes diagnosis came after the …
less likely to occur, with a 52% lower odds of keratoconus … As for some reports
linking increased risk of keratoconus to diabetes, diabetes diagnosis came after the …
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[PDF] DETECTION OF KERATOCONUS DISEASE DEPENDING ON CORNEAL TOPOGRAPHY USING DEEP LEARNING
AA Hashim, M Mazinani… for keratoconus identification using corneal topography pictures. Images from 170
keratoconus patients, 28 subclinical keratoconus patients, … The datasets were
collected from more than 1900 keratoconus patients in the keratoconus center of the …
AA Hashim, M Mazinani
… for keratoconus identification using corneal topography pictures. Images from 170
keratoconus patients, 28 subclinical keratoconus patients, … The datasets were
collected from more than 1900 keratoconus patients in the keratoconus center of the …
keratoconus patients, 28 subclinical keratoconus patients, … The datasets were
collected from more than 1900 keratoconus patients in the keratoconus center of the …
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[HTML] Coinfection of Herpes Simplex virus 2 and Mycobacterium chelonae in Acute Hydrops Associated with Keratoconus: A Case Report
P Marques-Couto, A Gama-Castro, T Carvalho… - IDCases, 2025… Our hypothesis is that this complication of keratoconus disrupts the normal
corneal barrier function, thereby increasing the susceptibility to infections including
those caused by nontuberculous mycobacteria similar to what might be observed …
P Marques-Couto, A Gama-Castro, T Carvalho… - IDCases, 2025
… Our hypothesis is that this complication of keratoconus disrupts the normal
corneal barrier function, thereby increasing the susceptibility to infections including
those caused by nontuberculous mycobacteria similar to what might be observed …
corneal barrier function, thereby increasing the susceptibility to infections including
those caused by nontuberculous mycobacteria similar to what might be observed …
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Sleeping Behavior and Keratoconus: A Scoping Review
A Tello, AP Navarro, A Pedraza-Concha, JV Sylvia… - Ceska a slovenska …, 2025Aims This study was planned to explore the efficacy of autologous blood as a
stabilizing agent for graft surgery in pterygium. Material and methods For this
observational, non-comparative, interventional study, the hospital data of patients …
A Tello, AP Navarro, A Pedraza-Concha, JV Sylvia… - Ceska a slovenska …, 2025
Aims This study was planned to explore the efficacy of autologous blood as a
stabilizing agent for graft surgery in pterygium. Material and methods For this
observational, non-comparative, interventional study, the hospital data of patients …
stabilizing agent for graft surgery in pterygium. Material and methods For this
observational, non-comparative, interventional study, the hospital data of patients …
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Evaluating the Influence of Eye Rubbing and Genetic Predisposition on Keratoconus in Bucaramanga (Colombia): A Case-control Study
ML Duarte-Bueno, A Tello, AL Diaz-Martínez… - Ceska a slovenska …, 2025… Conclusion: Eye rubbing and family history of keratoconus were the most
important risk factors for keratoconus in our population. Although … of keratoconus.
Other factors, such as sun exposure, sleeping position, and atopy, may play a role in …
ML Duarte-Bueno, A Tello, AL Diaz-Martínez… - Ceska a slovenska …, 2025
… Conclusion: Eye rubbing and family history of keratoconus were the most
important risk factors for keratoconus in our population. Although … of keratoconus.
Other factors, such as sun exposure, sleeping position, and atopy, may play a role in …
important risk factors for keratoconus in our population. Although … of keratoconus.
Other factors, such as sun exposure, sleeping position, and atopy, may play a role in …
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Enhancing early detection of keratoconus suspects using interocular corneal tomography asymmetry
S Li, Y Huo, R Xie, Y Han, H Zou, Y Wang - International Ophthalmology, 2025… The global consensus on corneal ectasia is that it is a bilateral disease, and true
unilateral keratoconus does not exist [14]. We believe that bilateral asymmetry is a
key feature for the early diagnosis of keratoconus. Interocular asymmetries in clinical …
S Li, Y Huo, R Xie, Y Han, H Zou, Y Wang - International Ophthalmology, 2025
… The global consensus on corneal ectasia is that it is a bilateral disease, and true
unilateral keratoconus does not exist [14]. We believe that bilateral asymmetry is a
key feature for the early diagnosis of keratoconus. Interocular asymmetries in clinical …
unilateral keratoconus does not exist [14]. We believe that bilateral asymmetry is a
key feature for the early diagnosis of keratoconus. Interocular asymmetries in clinical …
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[HTML] Accuracy of keratoconus-specific formulae compared to standard formulae for intraocular lens power calculation in patients with keratoconus
N Kahuam-López, JYM Ling, A Iovieno, SN Yeung - Canadian Journal of Ophthalmology… -specific formulae would result in improved refractive outcomes compared with
standard formulae and a machine learning-based thick IOL calculation formula for
IOL power estimation in keratoconus in a large cohort of keratoconus patients who …
N Kahuam-López, JYM Ling, A Iovieno, SN Yeung - Canadian Journal of Ophthalmology
… -specific formulae would result in improved refractive outcomes compared with
standard formulae and a machine learning-based thick IOL calculation formula for
IOL power estimation in keratoconus in a large cohort of keratoconus patients who …
standard formulae and a machine learning-based thick IOL calculation formula for
IOL power estimation in keratoconus in a large cohort of keratoconus patients who …
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tomography asymmetry
S Li, Y Huo, R Xie, Y Han, H Zou, Y Wang - International Ophthalmology, 2025… The global consensus on corneal ectasia is that it is a bilateral disease, and true
unilateral keratoconus does not exist [14]. We believe that bilateral asymmetry is a
key feature for the early diagnosis of keratoconus. Interocular asymmetries in clinical …
S Li, Y Huo, R Xie, Y Han, H Zou, Y Wang - International Ophthalmology, 2025
… The global consensus on corneal ectasia is that it is a bilateral disease, and true
unilateral keratoconus does not exist [14]. We believe that bilateral asymmetry is a
key feature for the early diagnosis of keratoconus. Interocular asymmetries in clinical …
unilateral keratoconus does not exist [14]. We believe that bilateral asymmetry is a
key feature for the early diagnosis of keratoconus. Interocular asymmetries in clinical …
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[HTML] Accuracy of keratoconus-specific formulae compared to standard formulae for intraocular lens power calculation in patients with keratoconus
N Kahuam-López, JYM Ling, A Iovieno, SN Yeung - Canadian Journal of Ophthalmology… -specific formulae would result in improved refractive outcomes compared with
standard formulae and a machine learning-based thick IOL calculation formula for
IOL power estimation in keratoconus in a large cohort of keratoconus patients who …
N Kahuam-López, JYM Ling, A Iovieno, SN Yeung - Canadian Journal of Ophthalmology
… -specific formulae would result in improved refractive outcomes compared with
standard formulae and a machine learning-based thick IOL calculation formula for
IOL power estimation in keratoconus in a large cohort of keratoconus patients who …
standard formulae and a machine learning-based thick IOL calculation formula for
IOL power estimation in keratoconus in a large cohort of keratoconus patients who …
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[HTML] Proteomics Reveals Mechanisms of Delayed Keratoconus Progression: A Study of Corneas Following Two Light-Activated Crosslinking Treatments
DHJ Vogels, J Brekelmans, R Mohren, NRN Vos… - … Ophthalmology & Visual …, 2025Purpose: This study aims to elucidate on changes in biological pathways in rabbit
corneas induced by two methods of light-activated corneal stiffening: topical
application of riboflavin with dextran (RF-D) or WST11 with dextran (WST-D) …
DHJ Vogels, J Brekelmans, R Mohren, NRN Vos… - … Ophthalmology & Visual …, 2025
Purpose: This study aims to elucidate on changes in biological pathways in rabbit
corneas induced by two methods of light-activated corneal stiffening: topical
application of riboflavin with dextran (RF-D) or WST11 with dextran (WST-D) …
corneas induced by two methods of light-activated corneal stiffening: topical
application of riboflavin with dextran (RF-D) or WST11 with dextran (WST-D) …
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[HTML] Corneal biomechanics: A diagnostic tool for differentiating high astigmatism and mild keratoconus
N Razak, WHWA Halim, B Mohd-Ali - African Vision and Eye Health, 2025Background: High astigmatism (HA) can be misinterpreted as keratoconus (KCN), is
highly prone to developing KCN and is normally reconfirmed using corneal
topography. Aim: To determine the diagnostic value of corneal biomechanical …
N Razak, WHWA Halim, B Mohd-Ali - African Vision and Eye Health, 2025
Background: High astigmatism (HA) can be misinterpreted as keratoconus (KCN), is
highly prone to developing KCN and is normally reconfirmed using corneal
topography. Aim: To determine the diagnostic value of corneal biomechanical …
highly prone to developing KCN and is normally reconfirmed using corneal
topography. Aim: To determine the diagnostic value of corneal biomechanical …
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[HTML] Diagnostic performance of corneal epithelium-and Bowman's layer thickness mapping in patients with unilateral Keratoconus
N Pircher, R Kilian, F Beer, R Donner, P Roberts… - Graefe's Archive for Clinical …, 2025… Several publications have described cases of unilateral keratoconus (UKC),
where only one eye presents with clinical KC, whereas the fellow eye (FE) shows no
topographic signs of corneal ectasia [16, 18]. Since many of the FE will go on …
N Pircher, R Kilian, F Beer, R Donner, P Roberts… - Graefe's Archive for Clinical …, 2025
… Several publications have described cases of unilateral keratoconus (UKC),
where only one eye presents with clinical KC, whereas the fellow eye (FE) shows no
topographic signs of corneal ectasia [16, 18]. Since many of the FE will go on …
where only one eye presents with clinical KC, whereas the fellow eye (FE) shows no
topographic signs of corneal ectasia [16, 18]. Since many of the FE will go on …
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Self-reported prevalence and risk factors associated with keratoconus among the adult population of Trinidad and Tobago: a cross-sectional study
NE Ezinne, MA Kwarteng, KP Mashige, VR Moodley - International Ophthalmology, 2025… Early screening for keratoconus in this country is strongly recommended to
facilitate prompt … across 15 countries estimated the global prevalence of
keratoconus to be 138 per 100,000 [8]. The … Keratoconus is one of the major …
NE Ezinne, MA Kwarteng, KP Mashige, VR Moodley - International Ophthalmology, 2025
… Early screening for keratoconus in this country is strongly recommended to
facilitate prompt … across 15 countries estimated the global prevalence of
keratoconus to be 138 per 100,000 [8]. The … Keratoconus is one of the major …
facilitate prompt … across 15 countries estimated the global prevalence of
keratoconus to be 138 per 100,000 [8]. The … Keratoconus is one of the major …
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Corneal stromal cells from patients with keratoconus exhibit alterations in the ESCRT-dependent machinery responsible for multivesicular body formation
N Blanco-Agudín, S Ye, I Alcalde, MD Corte-Torres… - Experimental Eye Research, 2025Previous studies have reported that exosomes produced by corneal stromal cells
from keratoconus patients exhibit a molecular content distinct from those produced
by cells from healthy donors. This study investigates differences in the expression of …
N Blanco-Agudín, S Ye, I Alcalde, MD Corte-Torres… - Experimental Eye Research, 2025
Previous studies have reported that exosomes produced by corneal stromal cells
from keratoconus patients exhibit a molecular content distinct from those produced
by cells from healthy donors. This study investigates differences in the expression of …
from keratoconus patients exhibit a molecular content distinct from those produced
by cells from healthy donors. This study investigates differences in the expression of …
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[PDF] Management of advanced keratoconus using a semi-scleral contact lens: A non-surgical option
ZA Rashid, VR Moodley, ZA Rashid… CLs in a patient with advanced keratoconus. A 23-year-old female, referred for CL
fitting, presented with advanced keratoconus with minimal … report shows that semi-scleral
CLs provide a satisfactory, non-surgical alternative to improve VA in patients with …
ZA Rashid, VR Moodley, ZA Rashid
… CLs in a patient with advanced keratoconus. A 23-year-old female, referred for CL
fitting, presented with advanced keratoconus with minimal … report shows that semi-scleral
CLs provide a satisfactory, non-surgical alternative to improve VA in patients with …
fitting, presented with advanced keratoconus with minimal … report shows that semi-scleral
CLs provide a satisfactory, non-surgical alternative to improve VA in patients with …
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[HTML] Topographic Pattern-Based Nomogram to Guide Keraring Implantation in Eyes with Mild to Moderate Keratoconus: Visual and Refractive Outcome
U de Sanctis, P Caselgrandi, C Gennaro, C Tosi… - Journal of Clinical Medicine, 2025Background: To assess the outcome of Keraring (Mediphacos, Brazil) implantation
according to a topographic pattern-based nomogram in eyes with mild to moderate
keratoconus. Materials and Methods: A topographic pattern-based nomogram was …
U de Sanctis, P Caselgrandi, C Gennaro, C Tosi… - Journal of Clinical Medicine, 2025
Background: To assess the outcome of Keraring (Mediphacos, Brazil) implantation
according to a topographic pattern-based nomogram in eyes with mild to moderate
keratoconus. Materials and Methods: A topographic pattern-based nomogram was …
according to a topographic pattern-based nomogram in eyes with mild to moderate
keratoconus. Materials and Methods: A topographic pattern-based nomogram was …
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[HTML] Different keratoconus definitions can lead to substantial prevalence disparities in population-based studies
H Shabani, BTH van Dooren, MA Meester-Smoor… - Scientific Reports, 2025… This report explores the prevalence of keratoconus in a population-based cohort
of adults aged 40 or older according to ten different … Suspected keratoconus was
defined as having at least one eye with a final D-index (BAD-D) ≥ 2.6. Manifest …
H Shabani, BTH van Dooren, MA Meester-Smoor… - Scientific Reports, 2025
… This report explores the prevalence of keratoconus in a population-based cohort
of adults aged 40 or older according to ten different … Suspected keratoconus was
defined as having at least one eye with a final D-index (BAD-D) ≥ 2.6. Manifest …
of adults aged 40 or older according to ten different … Suspected keratoconus was
defined as having at least one eye with a final D-index (BAD-D) ≥ 2.6. Manifest …
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[HTML] The cellular response of lipopolysaccharide-induced inflammation in keratoconus human corneal fibroblasts to RB-PDT: Insights into cytokines, chemokines and …
N Chai, T Stachon, S Häcker, T Berger, Z Li, M Amini… - PloS one, 2025Purpose Rose Bengal Photodynamic Therapy (RB-PDT) offers dual therapeutic
benefits by enhancing corneal stiffness and providing antibacterial activity,
presenting significant potential for patients with keratoconus complicated by keratitis …
N Chai, T Stachon, S Häcker, T Berger, Z Li, M Amini… - PloS one, 2025
Purpose Rose Bengal Photodynamic Therapy (RB-PDT) offers dual therapeutic
benefits by enhancing corneal stiffness and providing antibacterial activity,
presenting significant potential for patients with keratoconus complicated by keratitis …
benefits by enhancing corneal stiffness and providing antibacterial activity,
presenting significant potential for patients with keratoconus complicated by keratitis …
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[HTML] Distinct Ocular Surface Microbiome in Keratoconus Patients Correlate With Local Immune Dysregulation
NR Kumar, P Khamar, R Kannan, A Padmanabhan… - … Ophthalmology & Visual …, 2025Purpose: Keratoconus (KC) is characterized by irregular astigmatism along with
corneal stromal weakness and is associated with altered immune status. Tissue
resident microbiomes are known to influence the immune status in other organs, but …
NR Kumar, P Khamar, R Kannan, A Padmanabhan… - … Ophthalmology & Visual …, 2025
Purpose: Keratoconus (KC) is characterized by irregular astigmatism along with
corneal stromal weakness and is associated with altered immune status. Tissue
resident microbiomes are known to influence the immune status in other organs, but …
corneal stromal weakness and is associated with altered immune status. Tissue
resident microbiomes are known to influence the immune status in other organs, but …
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Advanced Keratoconus with Hydrops: Light at the End of the Tunnel
K Bhardwaj, T Chauhan, S Vohra, G Dabas… - Resolving Dilemmas in …, 2025The rupture of the Descemet membrane in an acute setting leads to a condition
called acute corneal hydrops. While its incidence is low, it can be encountered in
those with weakened and thin corneas such as those with advanced keratoconus …
K Bhardwaj, T Chauhan, S Vohra, G Dabas… - Resolving Dilemmas in …, 2025
The rupture of the Descemet membrane in an acute setting leads to a condition
called acute corneal hydrops. While its incidence is low, it can be encountered in
those with weakened and thin corneas such as those with advanced keratoconus …
called acute corneal hydrops. While its incidence is low, it can be encountered in
those with weakened and thin corneas such as those with advanced keratoconus …
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A Stitch in Time Saves Nine: Optic Neuritis in a Keratoconus Patient
S Monga - … in Ophthalmology: Challenging Cases, Diagnosis and …, 2025This chapter narrates the experience of managing a severe visual deficit due to
atypical optic neuritis, in a middle-aged male who was a known case of keratoconus.
The emphasis is on the importance of good clinical examination to elucidate the …
S Monga - … in Ophthalmology: Challenging Cases, Diagnosis and …, 2025
This chapter narrates the experience of managing a severe visual deficit due to
atypical optic neuritis, in a middle-aged male who was a known case of keratoconus.
The emphasis is on the importance of good clinical examination to elucidate the …
atypical optic neuritis, in a middle-aged male who was a known case of keratoconus.
The emphasis is on the importance of good clinical examination to elucidate the …
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Keratoconus staging, monitoring & corvis biomechanical analysis
E Flockerzi, B Seitz - Acta Ophthalmologica, 2025… reported to enable distinction between healthy and keratoconus corneas. The
main Corneal Visualization … keratoconus corneas in a quasi‐binary manner,
whereas the Biomechanical E‐Staging is based on the linear term of the CBI and …
E Flockerzi, B Seitz - Acta Ophthalmologica, 2025
… reported to enable distinction between healthy and keratoconus corneas. The
main Corneal Visualization … keratoconus corneas in a quasi‐binary manner,
whereas the Biomechanical E‐Staging is based on the linear term of the CBI and …
main Corneal Visualization … keratoconus corneas in a quasi‐binary manner,
whereas the Biomechanical E‐Staging is based on the linear term of the CBI and …
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Gene expression profiling of oxidative and anti‐oxidative genes in keratoconus patients
S Sharma, L Singh, S Kashyap, S Sen, N Sharma - Acta Ophthalmologica, 2025Aims/Purpose: Keratoconus (KC) is thinning of corneal stroma & irregular
astigmatism, resulting in diminution of vision. Despite its prevalence, the underlying
etiology is poorly understood. Emerging evidence suggests a dysregulation of …
S Sharma, L Singh, S Kashyap, S Sen, N Sharma - Acta Ophthalmologica, 2025
Aims/Purpose: Keratoconus (KC) is thinning of corneal stroma & irregular
astigmatism, resulting in diminution of vision. Despite its prevalence, the underlying
etiology is poorly understood. Emerging evidence suggests a dysregulation of …
astigmatism, resulting in diminution of vision. Despite its prevalence, the underlying
etiology is poorly understood. Emerging evidence suggests a dysregulation of …
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Topographic determinants of anterior chamber angle narrowing in patients with keratoconus
P Nabovati, H Soltan‐Dehghan, A Farzaneh… - Acta Ophthalmologica, 2025… visited a tertiary eye hospital and were diagnosed with keratoconus, were
recruited for this study. First… The keratoconus was diagnosed based on distorted
keratometric mires, scissoring of … with keratoconus as well as the presence of at …
P Nabovati, H Soltan‐Dehghan, A Farzaneh… - Acta Ophthalmologica, 2025
… visited a tertiary eye hospital and were diagnosed with keratoconus, were
recruited for this study. First… The keratoconus was diagnosed based on distorted
keratometric mires, scissoring of … with keratoconus as well as the presence of at …
recruited for this study. First… The keratoconus was diagnosed based on distorted
keratometric mires, scissoring of … with keratoconus as well as the presence of at …
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[PDF] Managing Bilateral Vernal Keratoconjunctivitis, Keratoconus, and Steroid-Induced Glaucoma: A Threefold Struggle
NH Maffar, Y Azhany, NASM Ghazali, J Muhammed… - Cureus, 2025… In this case report, we present a young Malay girl with VKC complicated by
progressive keratoconus and steroid-induced glaucoma, … 2), and marked
progression of keratoconus with thin corneal thickness in the right eye and minimal …
NH Maffar, Y Azhany, NASM Ghazali, J Muhammed… - Cureus, 2025
… In this case report, we present a young Malay girl with VKC complicated by
progressive keratoconus and steroid-induced glaucoma, … 2), and marked
progression of keratoconus with thin corneal thickness in the right eye and minimal …
progressive keratoconus and steroid-induced glaucoma, … 2), and marked
progression of keratoconus with thin corneal thickness in the right eye and minimal …
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Optimizing keratoconus treatment with AI‐driven lenticule matching using pentacam indices
F Doroodgar, S Niazi, H Nematy - Acta Ophthalmologica, 2025Aims/Purpose: The aim of this study is to develop an advanced artificial intelligence (AI)
methodology to optimize the matching of donor and recipient lenticules for the
treatment of keratoconus. This approach leverages Pentacam indices related to …
F Doroodgar, S Niazi, H Nematy - Acta Ophthalmologica, 2025
Aims/Purpose: The aim of this study is to develop an advanced artificial intelligence (AI)
methodology to optimize the matching of donor and recipient lenticules for the
treatment of keratoconus. This approach leverages Pentacam indices related to …
methodology to optimize the matching of donor and recipient lenticules for the
treatment of keratoconus. This approach leverages Pentacam indices related to …
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Vitamin D supplementation modifies clinical and biological markers of keratoconus progression
G Ferrari, S Palombella, N Bartolomeo, G Tilaro… - Acta Ophthalmologica, 2025Aims/Purpose: evaluation of vitamin D (Vit D) supplementation on clinical
progression and systemic biomarkers in adolescent patients affected by keratoconus
(KC) and Vit D insufficiency. Methods: forty adolescent patients (age range: 12–19) …
G Ferrari, S Palombella, N Bartolomeo, G Tilaro… - Acta Ophthalmologica, 2025
Aims/Purpose: evaluation of vitamin D (Vit D) supplementation on clinical
progression and systemic biomarkers in adolescent patients affected by keratoconus
(KC) and Vit D insufficiency. Methods: forty adolescent patients (age range: 12–19) …
progression and systemic biomarkers in adolescent patients affected by keratoconus
(KC) and Vit D insufficiency. Methods: forty adolescent patients (age range: 12–19) …
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Computational and experimental mechanical characterization of a novel corneal implant for the treatment of keratoconus
GM Ragonese, D Carbonaro, S Zambon, E Villa… - Acta Ophthalmologica, 2025Aims/Purpose: Current treatment options of keratoconus have several limitations.
These limitations have been addressed by developing a novel nitinol GROSSO®
implant, that restores the physiological curvature of the cornea by virtue of a dome‐shaped …
GM Ragonese, D Carbonaro, S Zambon, E Villa… - Acta Ophthalmologica, 2025
Aims/Purpose: Current treatment options of keratoconus have several limitations.
These limitations have been addressed by developing a novel nitinol GROSSO®
implant, that restores the physiological curvature of the cornea by virtue of a dome‐shaped …
These limitations have been addressed by developing a novel nitinol GROSSO®
implant, that restores the physiological curvature of the cornea by virtue of a dome‐shaped …
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Understanding structural changes in keratoconus: Anterior scleral and choroidal thickness analysis using swept source optical coherence tomography
A Hassairi, C Ahmed, O Mehdi, R Limaiem - Acta Ophthalmologica, 2025Aims/Purpose: The study aims to investigate the anterior scleral thickness (AST)
profile and choroidal thickness (CT) variations in keratoconus (KC) patients
compared to healthy controls, with the objective of providing a comprehensive …
A Hassairi, C Ahmed, O Mehdi, R Limaiem - Acta Ophthalmologica, 2025
Aims/Purpose: The study aims to investigate the anterior scleral thickness (AST)
profile and choroidal thickness (CT) variations in keratoconus (KC) patients
compared to healthy controls, with the objective of providing a comprehensive …
profile and choroidal thickness (CT) variations in keratoconus (KC) patients
compared to healthy controls, with the objective of providing a comprehensive …
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Tear proteomics for the understanding of corneal biomechanical weakness in offspring of keratoconus patients
M López‐López, T Alvite‐Piñeiro, Y Pastoriza, I Lema… - Acta Ophthalmologica, 2025Aim: To analyze the tear proteome of offspring of keratoconus patients (O‐KC) to
elucidate the molecular mechanisms involved in corneal weakening in high‐risk
individuals. Methods: 80 O‐KC young participants matched with 42 control subjects …
M López‐López, T Alvite‐Piñeiro, Y Pastoriza, I Lema… - Acta Ophthalmologica, 2025
Aim: To analyze the tear proteome of offspring of keratoconus patients (O‐KC) to
elucidate the molecular mechanisms involved in corneal weakening in high‐risk
individuals. Methods: 80 O‐KC young participants matched with 42 control subjects …
elucidate the molecular mechanisms involved in corneal weakening in high‐risk
individuals. Methods: 80 O‐KC young participants matched with 42 control subjects …
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Intraocular lens power calculation in cataract patients with keratoconus: Bayesian network meta-analysis
ZY Tian, M Li, JS Zhang, YY Mao, ZX Guo, X Zheng… - International Ophthalmology, 2025… for keratoconus predicted posterior corneal astigmatism (Barrett KC P-PCA),
EVO2. 0, and Barrett True-K formula for keratoconus measured … In the range of±1.00
D, the top three formulas were Barrett KC P-PCA, Barrett KC M-PCA and Kane for …
ZY Tian, M Li, JS Zhang, YY Mao, ZX Guo, X Zheng… - International Ophthalmology, 2025
… for keratoconus predicted posterior corneal astigmatism (Barrett KC P-PCA),
EVO2. 0, and Barrett True-K formula for keratoconus measured … In the range of±1.00
D, the top three formulas were Barrett KC P-PCA, Barrett KC M-PCA and Kane for …
EVO2. 0, and Barrett True-K formula for keratoconus measured … In the range of±1.00
D, the top three formulas were Barrett KC P-PCA, Barrett KC M-PCA and Kane for …
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[HTML] Ineffectiveness of KeraVio Treatment with Violet Light-Emitting Glasses Without Riboflavin Drops for Progressive Keratoconus
H Kobashi, T Kumanomido, T Ide, N Kato, J Shimazaki… - Journal of Clinical Medicine, 2025… This study aimed to report the clinical outcomes of KeraVio with VL irradiation
without the administration of riboflavin drops in patients with progressive keratoconus. …
This may suggest that KeraVio treatment with VL alone was not effective in preventing …
H Kobashi, T Kumanomido, T Ide, N Kato, J Shimazaki… - Journal of Clinical Medicine, 2025
… This study aimed to report the clinical outcomes of KeraVio with VL irradiation
without the administration of riboflavin drops in patients with progressive keratoconus. …
This may suggest that KeraVio treatment with VL alone was not effective in preventing …
without the administration of riboflavin drops in patients with progressive keratoconus. …
This may suggest that KeraVio treatment with VL alone was not effective in preventing …
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![[Video] Adverse Eye Rubbing in Keratoconus](https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg4HRiK6MvFtia856foWYkBDP2bCVe0NB-S445VtbzLVYY19KJ6Pma-J-xabIQgjfE3RyTgr5C7Y9IvGs6PZ2ofcR13vtnGSwqghFJv40mZdjUD4VyOfjGN03Fhyphenhyphenziai2VNOASlDExTi77TdfDrh2yKeS735QlfIwwLZhn0xilsHeLiGDvhshth384ZzgBu/w72-h72-p-k-no-nu/keratoconus-pathogenesis.jpg)
